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Tuesday, February 1, 2011

Community Demographics & Shelter Adoptions



This study explored the joint effect of distance and neighborhood-level demographics on pet adoptions from an animal shelter. The methods used to perform the study were client segmentation, geospatial tools, and epidemiological techniques that evaluated locations of 1,563 adoptions from an animal shelter in eastern Massachusetts. Proximity to the shelter was found to be strongly associated with adoption. Locations that were less than 6 miles (9.7 km) from the shelter having higher block group median income, or having a greater proportion of households that were composed of married couples with children in the block group, were associated with increased odds of being an adoption location. Neighborhood lifestyle characteristics were also noted to profoundly influence shelter adoption patterns. This study explored pet adoptions as one aspect of shelter operations. There are other potential applications of this type of technology and analysis for shelter outreach in identifying underserved areas for mobile spay-neuter programs, improvement of allocation of animal control resources, better targeting of media messages about the shelter, along with other possibilities.  [VT]

Related articles:
Patronek GJ: Mapping and measuring disparities in welfare for cats across neighborhoods in a large US city, J Am Vet Med Assoc 71: 161, 2010.

More on cat health: Winn Feline Foundation Library
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Follow us on Twitter


This study explored the joint effect of distance and neighborhood-level demographics on pet adoptions from an animal shelter. The methods used to perform the study were client segmentation, geospatial tools, and epidemiological techniques that evaluated locations of 1,563 adoptions from an animal shelter in eastern Massachusetts. Proximity to the shelter was found to be strongly associated with adoption. Locations that were less than 6 miles (9.7 km) from the shelter having higher block group median income, or having a greater proportion of households that were composed of married couples with children in the block group, were associated with increased odds of being an adoption location. Neighborhood lifestyle characteristics were also noted to profoundly influence shelter adoption patterns. This study explored pet adoptions as one aspect of shelter operations. There are other potential applications of this type of technology and analysis for shelter outreach in identifying underserved areas for mobile spay-neuter programs, improvement of allocation of animal control resources, better targeting of media messages about the shelter, along with other possibilities.  [VT]

Related articles:
Patronek GJ: Mapping and measuring disparities in welfare for cats across neighborhoods in a large US city, J Am Vet Med Assoc 71: 161, 2010.

More on cat health: Winn Feline Foundation Library
Join us on Facebook
Follow us on Twitter
Read More


Monday, January 31, 2011

Surgeons, medical device makers find insurers resisting costly back fusions

Surgeons and medical device makers find insurers are resisting costly back fusions and requiring proof that less risky therapy for pain has been given a chance.
Surgeons and medical device makers find insurers are resisting costly back fusions and requiring proof that less risky therapy for pain has been given a chance.
Read More


Government opens investigation into adult scoliosis treatments

The federal government has launched an investigation into the treatment used in adult scoliosis.
Posted: 6:20 PM Jan 24, 2011
Reporter: Maureen McFadden




The federal government has launched an investigation into the treatment used in adult scoliosis.
Julia Epper, an adult scoliosis patient, used to backstitch, until she developed adult scoliosis.
"I've had back pain since I was 14," said Epper, “It was very frustrating and I felt very limited.”
Diagnosed at age 20 her spine curve grew from 24 degrees, to 54.

Attempts at physical therapy and injections have done nothing for her pain either.
The Hospital for Special Surgery reports that half a million people have adult scoliosis in the United States, and 40 percent will feel more pain each year.

“Many people, as the spine begins to age, and the discs degenerate, beginning to experience more back and even leg pain,” says Charles C. Edwards II, a doctor at the Maryland Spine Center.
A new study shows spinal surgery may be the only true option.

"While we may try medicines and injections first, oftentimes we will move onto surgery because those other methods just are not making a difference for them," says Edwards.

In the United States alone, $860 billion are spent on therapy, braces, and pain injections.
The study, which includes patients from 40 to 80 years old, shows operative patients saw a significant boost in function and quality of life, while non-operative patients reported no improvement at all.
Decompression and fusion surgery worked for Epper, who says, "I no longer have this sharp, burning, debilitating pain. The difference has been remarkable."
Six centers across the US are currently involved in the government's adult scoliosis study.
All six centers are currently enrolling patients with results expected in 2015.

Research Summary:
BENT OUT OF SHAPE: THE ADULT SCOLIOSIS DEBATE
REPORT # 1744

BACKGROUND: Any individual over the age of 18 who has experienced spinal deformity is considered to have adult scoliosis. Scoliosis is defined as an abnormal, side-to-side, curvature of the spine. There are varying causes of spinal deformity including; idiopathic scoliosis, congenital anomalies, degenerative scoliosis, posttraumatic scoliosis and neuro-muscular scoliosis. Idiopathic scoliosis is the most common form of spinal deformity doctors see, affecting about three percent of the general population. (SOURCE: Adult Scoliosis and Spine Associates)

THE BIRTH OF PAIN: It begins in childhood but advances in pain and deformity in adulthood. Congenital anomalies form in the uterus while degenerative scoliosis is caused by disc degeneration. As a result of spine fractures, posttraumatic scoliosis comes into existence and neuro-muscular scoliosis has been found to develop in patients with neuromuscular disorders like polio or muscular dystrophies. (SOURCE: Adult Scoliosis and Spine Associates)

SYMPTOMS OF SCOLIOSIS: Scoliosis is often painless with back pain eventually developing only as the condition progresses. Deformities may place unnecessary pressure on ones nerves and possibly even on the spinal cord. This can lead to weakness, numbness, and pain in the lower extremities. In severe, often very rare cases, pressure on the spinal cord may cause loss of coordination in the leg muscles, making it difficult to walk normally. If the chest is deformed due to scoliosis, the lungs and heart may also be affected. This can promote breathing problems, fatigue, and even heart failure. (SOURCE: www.allaboutbackandneckpain.com)

SIMPLE SCOLIOSIS TEST: Aside from experiencing back discomfort, what'll typically bring a patient to the doctor are the noticeable changes in ones back. Some signs that may lead an individual to the doctor include one shoulder or hip higher than the other, one shoulder blade higher or sticking out farther than the other, a hump in the back that sticks up when bending forward, one arm hanging longer than the other or the waist appearing asymmetrical. (SOURCE: www.iscoliosis.com)

TREATMENT: Some adult scoliosis treatment doesn't require surgery. A combination of physical therapy, exercise and Ibuprofen can serve as a recommended treatment. Steroid injections are sometimes used to treat pinched nerves. Surgery is only recommended if pain is unresponsive to non-operative treatment. (SOURCE: www.healthcentral.com)

* For More Information, Contact:
Mr. Ryan Andrews
Research Assistant
(410) 539-3434
rkandrews87@gmail.com
The federal government has launched an investigation into the treatment used in adult scoliosis.
Posted: 6:20 PM Jan 24, 2011
Reporter: Maureen McFadden




The federal government has launched an investigation into the treatment used in adult scoliosis.
Julia Epper, an adult scoliosis patient, used to backstitch, until she developed adult scoliosis.
"I've had back pain since I was 14," said Epper, “It was very frustrating and I felt very limited.”
Diagnosed at age 20 her spine curve grew from 24 degrees, to 54.

Attempts at physical therapy and injections have done nothing for her pain either.
The Hospital for Special Surgery reports that half a million people have adult scoliosis in the United States, and 40 percent will feel more pain each year.

“Many people, as the spine begins to age, and the discs degenerate, beginning to experience more back and even leg pain,” says Charles C. Edwards II, a doctor at the Maryland Spine Center.
A new study shows spinal surgery may be the only true option.

"While we may try medicines and injections first, oftentimes we will move onto surgery because those other methods just are not making a difference for them," says Edwards.

In the United States alone, $860 billion are spent on therapy, braces, and pain injections.
The study, which includes patients from 40 to 80 years old, shows operative patients saw a significant boost in function and quality of life, while non-operative patients reported no improvement at all.
Decompression and fusion surgery worked for Epper, who says, "I no longer have this sharp, burning, debilitating pain. The difference has been remarkable."
Six centers across the US are currently involved in the government's adult scoliosis study.
All six centers are currently enrolling patients with results expected in 2015.

Research Summary:
BENT OUT OF SHAPE: THE ADULT SCOLIOSIS DEBATE
REPORT # 1744

BACKGROUND: Any individual over the age of 18 who has experienced spinal deformity is considered to have adult scoliosis. Scoliosis is defined as an abnormal, side-to-side, curvature of the spine. There are varying causes of spinal deformity including; idiopathic scoliosis, congenital anomalies, degenerative scoliosis, posttraumatic scoliosis and neuro-muscular scoliosis. Idiopathic scoliosis is the most common form of spinal deformity doctors see, affecting about three percent of the general population. (SOURCE: Adult Scoliosis and Spine Associates)

THE BIRTH OF PAIN: It begins in childhood but advances in pain and deformity in adulthood. Congenital anomalies form in the uterus while degenerative scoliosis is caused by disc degeneration. As a result of spine fractures, posttraumatic scoliosis comes into existence and neuro-muscular scoliosis has been found to develop in patients with neuromuscular disorders like polio or muscular dystrophies. (SOURCE: Adult Scoliosis and Spine Associates)

SYMPTOMS OF SCOLIOSIS: Scoliosis is often painless with back pain eventually developing only as the condition progresses. Deformities may place unnecessary pressure on ones nerves and possibly even on the spinal cord. This can lead to weakness, numbness, and pain in the lower extremities. In severe, often very rare cases, pressure on the spinal cord may cause loss of coordination in the leg muscles, making it difficult to walk normally. If the chest is deformed due to scoliosis, the lungs and heart may also be affected. This can promote breathing problems, fatigue, and even heart failure. (SOURCE: www.allaboutbackandneckpain.com)

SIMPLE SCOLIOSIS TEST: Aside from experiencing back discomfort, what'll typically bring a patient to the doctor are the noticeable changes in ones back. Some signs that may lead an individual to the doctor include one shoulder or hip higher than the other, one shoulder blade higher or sticking out farther than the other, a hump in the back that sticks up when bending forward, one arm hanging longer than the other or the waist appearing asymmetrical. (SOURCE: www.iscoliosis.com)

TREATMENT: Some adult scoliosis treatment doesn't require surgery. A combination of physical therapy, exercise and Ibuprofen can serve as a recommended treatment. Steroid injections are sometimes used to treat pinched nerves. Surgery is only recommended if pain is unresponsive to non-operative treatment. (SOURCE: www.healthcentral.com)

* For More Information, Contact:
Mr. Ryan Andrews
Research Assistant
(410) 539-3434
rkandrews87@gmail.com
Read More


Thursday, January 27, 2011

Issue 108: From Jordan's Desk - Bone Fat?

It sounds like a contradiction in terms, but having too much fat in the bones can lead to thinning bones. What’s more is that this negates previous research which suggested that carrying extra weight and fat protected women against bone thinning and loss.

Here’s the skinny on the bone fat: Women with too much fat around the middle may compromise their bone health and be at greater risk for osteoporosis. Doctors at Massachusetts General Hospital studied 50 premenopausal women with an average body mass index (BMI) of 30. The women’s bone marrow fat and bone mineral density were also measured to determine their bone mass and bone loss.

The researchers were particularly interested in visceral fat—a kind of fat that exists below the muscle tissue in the stomach—compared to fat that is located just under the skin called subcutaneous fat. Visceral fat is believed to be the more dangerous of two, as it has been implicated in greater risk of heart disease. In this case, the doctors wanted to see if there was a difference in osteoporosis risk dependent upon which kind of fat the women had more of.

The doctors used imaging tests to discover that the study’s participants who had more visceral fat also had more bone marrow fat and less bone mineral density—which translated into a greater risk for osteoporosis. Interestingly, the researchers found no significant link between subcutaneous fat or total fat and bone marrow fat or bone mineral density.

Dr. Miriam Bredella, a radiologist at Massachusetts General and assistant professor of radiology at Harvard Medical School, was the lead author of the study. She says, “Our results show that having a lot of belly fat is more detrimental to bone health than having more superficial fat or fat around the hips.”

There may be more to the story, though. Dr. Leanne Chrisman, a family medicine doctor at University Hospitals Case Medical Center in Ohio says, “The people who consume the most unhealthy carbohydrates and fats are the ones going to be the most obese, and they’re also the ones who are the most likely not to exercise. Weight-bearing exercise is associated with improved bone marrow densities. A lack of exercise is associated with being obese and low bone mass.” Additionally, says Chrisman, the more visceral fat you have, the more difficult it is for you to absorb nutrients that are crucial for good bone health, like calcium and vitamin D.

Lead study author, Dr. Bredella sums it up: “It is important for the public to be aware that excess belly fat is a risk factor for bone loss, as well as heart disease and diabetes."

So, if you need one more reason to lose that tummy…now you have it.
It sounds like a contradiction in terms, but having too much fat in the bones can lead to thinning bones. What’s more is that this negates previous research which suggested that carrying extra weight and fat protected women against bone thinning and loss.

Here’s the skinny on the bone fat: Women with too much fat around the middle may compromise their bone health and be at greater risk for osteoporosis. Doctors at Massachusetts General Hospital studied 50 premenopausal women with an average body mass index (BMI) of 30. The women’s bone marrow fat and bone mineral density were also measured to determine their bone mass and bone loss.

The researchers were particularly interested in visceral fat—a kind of fat that exists below the muscle tissue in the stomach—compared to fat that is located just under the skin called subcutaneous fat. Visceral fat is believed to be the more dangerous of two, as it has been implicated in greater risk of heart disease. In this case, the doctors wanted to see if there was a difference in osteoporosis risk dependent upon which kind of fat the women had more of.

The doctors used imaging tests to discover that the study’s participants who had more visceral fat also had more bone marrow fat and less bone mineral density—which translated into a greater risk for osteoporosis. Interestingly, the researchers found no significant link between subcutaneous fat or total fat and bone marrow fat or bone mineral density.

Dr. Miriam Bredella, a radiologist at Massachusetts General and assistant professor of radiology at Harvard Medical School, was the lead author of the study. She says, “Our results show that having a lot of belly fat is more detrimental to bone health than having more superficial fat or fat around the hips.”

There may be more to the story, though. Dr. Leanne Chrisman, a family medicine doctor at University Hospitals Case Medical Center in Ohio says, “The people who consume the most unhealthy carbohydrates and fats are the ones going to be the most obese, and they’re also the ones who are the most likely not to exercise. Weight-bearing exercise is associated with improved bone marrow densities. A lack of exercise is associated with being obese and low bone mass.” Additionally, says Chrisman, the more visceral fat you have, the more difficult it is for you to absorb nutrients that are crucial for good bone health, like calcium and vitamin D.

Lead study author, Dr. Bredella sums it up: “It is important for the public to be aware that excess belly fat is a risk factor for bone loss, as well as heart disease and diabetes."

So, if you need one more reason to lose that tummy…now you have it.
Read More


Wednesday, January 26, 2011

Are positive emotions good for your health in old age?

The notion that feeling good may be good for your health is not new, but is it really true? A new article published in Current Directions in Psychological Science, a journal of the Association for Psychological Science, reviews the existing research on how positive emotions can influence health outcomes in later adulthood.

"We all age. It is how we age, however, that determines the quality of our lives," said Anthony Ong of Cornell University, author of the review article. The data he reviews suggest that positive emotions may be a powerful antidote to stress, pain, and illness.

There are several pathways through which a positive attitude can protect against poor health later in life. For example, happier people might take a proactive approach to aging by regularly exercising and budgeting time for a good night's sleep. Alternately, these people may avoid unhealthy behaviors, such as smoking.The benefits of these healthy lifestyle choices may become more important in older adults, as their bodies become more susceptible to disease.

An optimistic outlook has also been shown to combat stress—a known risk factor for a lot of disease. Studies have found that people with stronger positive emotions have lower levels of chemicals associated with inflammation related to stress. Also, by adopting a positive attitude people may even be able to undo some of the physical damage caused by stress.

Ong, a developmental psychologist, became interested in the study of positive emotion during graduate school when he learned about what researchers call the paradox of aging: Despite the notable loss of physical function throughout the body, a person's emotional capacity seemed to stay consistent with age. Ong speculates that if positive emotions are indeed good for our health then, "one direct, measureable consequence of this should be the extended years of quality living."
The notion that feeling good may be good for your health is not new, but is it really true? A new article published in Current Directions in Psychological Science, a journal of the Association for Psychological Science, reviews the existing research on how positive emotions can influence health outcomes in later adulthood.

"We all age. It is how we age, however, that determines the quality of our lives," said Anthony Ong of Cornell University, author of the review article. The data he reviews suggest that positive emotions may be a powerful antidote to stress, pain, and illness.

There are several pathways through which a positive attitude can protect against poor health later in life. For example, happier people might take a proactive approach to aging by regularly exercising and budgeting time for a good night's sleep. Alternately, these people may avoid unhealthy behaviors, such as smoking.The benefits of these healthy lifestyle choices may become more important in older adults, as their bodies become more susceptible to disease.

An optimistic outlook has also been shown to combat stress—a known risk factor for a lot of disease. Studies have found that people with stronger positive emotions have lower levels of chemicals associated with inflammation related to stress. Also, by adopting a positive attitude people may even be able to undo some of the physical damage caused by stress.

Ong, a developmental psychologist, became interested in the study of positive emotion during graduate school when he learned about what researchers call the paradox of aging: Despite the notable loss of physical function throughout the body, a person's emotional capacity seemed to stay consistent with age. Ong speculates that if positive emotions are indeed good for our health then, "one direct, measureable consequence of this should be the extended years of quality living."
Read More


Tuesday, January 25, 2011

Medical Treatment for Feline Hyperthyroidism


Hyperthyroidism is the most common endocrine disorder in middle-aged and older cats. Medical management with the antithyroid drug methimazole has become a popular option, either before surgery (thyroidectomy) or radioiodine treatment, or for long-term medical management. Carbimazole is rapidly metabolized to methimazole in vivo. This cross-over study of 6 normal cats compared a single oral dose of either a controlled-release carbimazole tablet or a sugar-coated methimazole tablet. Both formulations are approved for use in cats and were found to be well tolerated by the cats in the course of the study. In general, the pharmacokinetic values for the two treatments were similar when differences in effective methimazole dose were taken into consideration. Both drugs were reported to have relatively short plasma half-lives in the current study that would seem to support either once or twice daily dosing for either. Methimazole accumulates in the thyroid gland so that antithyroid effects extend beyond (possibly up to 24 hours) the duration of elevated plasma levels.  Therefore, the short half-life of 3 hours for both controlled-release carbimazole and sugar-coated methimazole tablets is consistent with current practice recommendations for divided daily dosing, although once-daily dosing may be appropriate for maintenance therapy in some cats. [VT]

Related articles:

More on cat health: Winn Feline Foundation Library

Hyperthyroidism is the most common endocrine disorder in middle-aged and older cats. Medical management with the antithyroid drug methimazole has become a popular option, either before surgery (thyroidectomy) or radioiodine treatment, or for long-term medical management. Carbimazole is rapidly metabolized to methimazole in vivo. This cross-over study of 6 normal cats compared a single oral dose of either a controlled-release carbimazole tablet or a sugar-coated methimazole tablet. Both formulations are approved for use in cats and were found to be well tolerated by the cats in the course of the study. In general, the pharmacokinetic values for the two treatments were similar when differences in effective methimazole dose were taken into consideration. Both drugs were reported to have relatively short plasma half-lives in the current study that would seem to support either once or twice daily dosing for either. Methimazole accumulates in the thyroid gland so that antithyroid effects extend beyond (possibly up to 24 hours) the duration of elevated plasma levels.  Therefore, the short half-life of 3 hours for both controlled-release carbimazole and sugar-coated methimazole tablets is consistent with current practice recommendations for divided daily dosing, although once-daily dosing may be appropriate for maintenance therapy in some cats. [VT]

Related articles:

More on cat health: Winn Feline Foundation Library
Read More


Sunday, January 23, 2011

Eating More Fruit and Vegetables Is Linked to a Lower Risk of Dying from Ischemic Heart Disease

A European study investigating the links between diet and disease has found that people who consume more fruit and vegetables have a lower risk of dying from ischaemic heart disease -- the most common form of heart disease and one of the leading causes of death in Europe. However, the authors point out that a higher fruit and vegetable intake occurs among people with other healthy eating habits and lifestyles, and that these factors could also be associated with the lower risk of dying from IHD.

The study is published online on January 19 in the European Heart Journal.

Data analysed from the European Prospective Investigation into Cancer and Nutrition (EPIC) Heart study has shown that people who ate at least eight portions of fruit and vegetables a day had a 22% lower risk of dying from IHD than did those who consumed fewer than three portions a day. A portion weighed 80 grams, equal to a small banana, a medium apple, or a small carrot.

Dr Francesca Crowe of the Cancer Epidemiology Unit at the University of Oxford, UK, and the first author of the paper by the EPIC study collaborators, said: "This study involved over 300,000 people in eight different European countries, with 1,636 deaths from IHD. It shows a 4% reduced risk of dying from IHD for each additional portion of fruit and vegetables consumed above the lowest intake of two portions. In other words, the risk of a fatal IHD for someone eating five portions of fruit and vegetables a day would be 4% lower compared to someone consuming four portions a day, and so on up to eight portions or more."

Ischaemic heart disease (IHD) is characterised by reduced blood supply to the heart; people suffering from it can develop angina, chest pains and have a heart attack.

The EPIC study started in 1992 and recruited participants from a total of ten European countries* until 2000. For the analysis of IHD deaths, data from eight countries for people aged between 40 and 85 were used. Participants answered questions about their diet at the time of entry to the study and other questions about health, socio-economic status and life-style, such as smoking, drinking and exercise habits. They were followed-up for an average of nearly eight and a half years.

The researchers found that the average intake of fruit and vegetables was five portions a day; people in Greece, Italy and Spain ate more, and those in Sweden ate less.

When analysing the data, the researchers made allowances for confounding factors such as differences in lifestyles and eating habits. However, the study could be limited by errors in measuring correctly people's fruit and vegetable intake as well as other aspects of their diet. In addition, the study had a higher proportion of women, which might not be generalisable to the wider European population.

Dr Crowe said: "The main message from this analysis is that, in this study, people who consume more fruits and vegetables have lower risk of dying from IHD. However, we need to be cautious in our interpretation of the results because we are unsure whether the association between fruit and vegetable intake and risk of IHD is due to some other component of diet or lifestyle.

"If we could understand, by means of well-designed intervention studies, the biological mechanisms that could underlie the association between fruits and vegetables and IHD, this might help to determine whether or not the relation between fruit and vegetables with IHD risk is causal."

In an accompanying editorial, Professor Sir Michael Marmot, director of the University College London (UCL) International Institute for Society and Health, head of the UCL Department of Epidemiology and Public Health, and chairman of the Commission on Social Determinants of Health, writes that it is difficult to reach firm conclusions about causation from results that show a 22% lower risk of dying from IHD (an odds ration of 0.78) in people who eat eight portions of fruit and vegetables a day.

He continues: "Such an odds ratio is, however, of huge practical importance. Cardiovascular disease is the most common cause of death. A reduction of 22% is huge. But... this reduction in mortality comes with consumption of eight portions a day, or 640g. Such a high consumption was found in only 18% of the men and women in these eight cohorts. There would need to be big shift in dietary patterns to achieve this healthy consumption of eight portions a day. It is worth trying to move in that direction. Reductions in cancers of several sites, in blood pressure and stroke, would add to this reduction in fatal CHD. Moving to a diet that emphasises fruit and vegetables is of great importance to public health."

*The ten countries include: Denmark, France, Germany, Greece, Italy, The Netherlands, Norway, Spain, Sweden and the United Kingdom. For the Heart component of the study, data from France and Norway were excluded due to the small number of IHD deaths at the end of the follow-up period.
A European study investigating the links between diet and disease has found that people who consume more fruit and vegetables have a lower risk of dying from ischaemic heart disease -- the most common form of heart disease and one of the leading causes of death in Europe. However, the authors point out that a higher fruit and vegetable intake occurs among people with other healthy eating habits and lifestyles, and that these factors could also be associated with the lower risk of dying from IHD.

The study is published online on January 19 in the European Heart Journal.

Data analysed from the European Prospective Investigation into Cancer and Nutrition (EPIC) Heart study has shown that people who ate at least eight portions of fruit and vegetables a day had a 22% lower risk of dying from IHD than did those who consumed fewer than three portions a day. A portion weighed 80 grams, equal to a small banana, a medium apple, or a small carrot.

Dr Francesca Crowe of the Cancer Epidemiology Unit at the University of Oxford, UK, and the first author of the paper by the EPIC study collaborators, said: "This study involved over 300,000 people in eight different European countries, with 1,636 deaths from IHD. It shows a 4% reduced risk of dying from IHD for each additional portion of fruit and vegetables consumed above the lowest intake of two portions. In other words, the risk of a fatal IHD for someone eating five portions of fruit and vegetables a day would be 4% lower compared to someone consuming four portions a day, and so on up to eight portions or more."

Ischaemic heart disease (IHD) is characterised by reduced blood supply to the heart; people suffering from it can develop angina, chest pains and have a heart attack.

The EPIC study started in 1992 and recruited participants from a total of ten European countries* until 2000. For the analysis of IHD deaths, data from eight countries for people aged between 40 and 85 were used. Participants answered questions about their diet at the time of entry to the study and other questions about health, socio-economic status and life-style, such as smoking, drinking and exercise habits. They were followed-up for an average of nearly eight and a half years.

The researchers found that the average intake of fruit and vegetables was five portions a day; people in Greece, Italy and Spain ate more, and those in Sweden ate less.

When analysing the data, the researchers made allowances for confounding factors such as differences in lifestyles and eating habits. However, the study could be limited by errors in measuring correctly people's fruit and vegetable intake as well as other aspects of their diet. In addition, the study had a higher proportion of women, which might not be generalisable to the wider European population.

Dr Crowe said: "The main message from this analysis is that, in this study, people who consume more fruits and vegetables have lower risk of dying from IHD. However, we need to be cautious in our interpretation of the results because we are unsure whether the association between fruit and vegetable intake and risk of IHD is due to some other component of diet or lifestyle.

"If we could understand, by means of well-designed intervention studies, the biological mechanisms that could underlie the association between fruits and vegetables and IHD, this might help to determine whether or not the relation between fruit and vegetables with IHD risk is causal."

In an accompanying editorial, Professor Sir Michael Marmot, director of the University College London (UCL) International Institute for Society and Health, head of the UCL Department of Epidemiology and Public Health, and chairman of the Commission on Social Determinants of Health, writes that it is difficult to reach firm conclusions about causation from results that show a 22% lower risk of dying from IHD (an odds ration of 0.78) in people who eat eight portions of fruit and vegetables a day.

He continues: "Such an odds ratio is, however, of huge practical importance. Cardiovascular disease is the most common cause of death. A reduction of 22% is huge. But... this reduction in mortality comes with consumption of eight portions a day, or 640g. Such a high consumption was found in only 18% of the men and women in these eight cohorts. There would need to be big shift in dietary patterns to achieve this healthy consumption of eight portions a day. It is worth trying to move in that direction. Reductions in cancers of several sites, in blood pressure and stroke, would add to this reduction in fatal CHD. Moving to a diet that emphasises fruit and vegetables is of great importance to public health."

*The ten countries include: Denmark, France, Germany, Greece, Italy, The Netherlands, Norway, Spain, Sweden and the United Kingdom. For the Heart component of the study, data from France and Norway were excluded due to the small number of IHD deaths at the end of the follow-up period.
Read More