A krill oil supplemented diet reduces the activities of the mitochondrial tricarboxylate carrier and of the cytosolic lipogenic enzymes in rats.

The mitochondrial tricarboxylate carrier supplies cytosol with the carbon units necessary for hepatic lipogenesis. The activities of cytosolic acetyl-CoA carboxylase and fatty acid synthetase are therefore strictly connected to the function of mitochondrial tricarboxylate carrier. Dietary polyunsaturated fatty acids (PUFA) are potent modulators of hepatic lipogenesis. In rats fed with a diet enriched with 2.5% krill oil (KO), a novel source of dietary n-3 PUFA, a time-dependent decrease in the activities of the mitochondrial tricarboxylate carrier and of the lipogenic enzymes was found.

The KO induced inhibition of hepatic lipogenesis was more pronounced than that found in fish oil (FO)-fed rats, at least at short feeding times. The decrease in the activity of the mitochondrial tricarboxylate carrier caused by KO was due to a reduced expression of the protein. Furthermore, in the KO-fed animals a greater reduction in the levels of hepatic triglycerides and cholesterol was found in comparison to FO-fed rats.

The mitochondrial tricarboxylate carrier supplies cytosol with the carbon units necessary for hepatic lipogenesis. The activities of cytosolic acetyl-CoA carboxylase and fatty acid synthetase are therefore strictly connected to the function of mitochondrial tricarboxylate carrier. Dietary polyunsaturated fatty acids (PUFA) are potent modulators of hepatic lipogenesis. In rats fed with a diet enriched with 2.5% krill oil (KO), a novel source of dietary n-3 PUFA, a time-dependent decrease in the activities of the mitochondrial tricarboxylate carrier and of the lipogenic enzymes was found.

The KO induced inhibition of hepatic lipogenesis was more pronounced than that found in fish oil (FO)-fed rats, at least at short feeding times. The decrease in the activity of the mitochondrial tricarboxylate carrier caused by KO was due to a reduced expression of the protein. Furthermore, in the KO-fed animals a greater reduction in the levels of hepatic triglycerides and cholesterol was found in comparison to FO-fed rats.

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Weight loss improves memory, research shows

Here's another good reason to lose weight: It may improve your memory and concentration, new research suggests.
Scientists know that overweight and obese people are at a greater risk for memory problems and other cognitive disabilities, but the latest study is one of the first to indicate that substantial weight loss improves brain health.
John Gunstad, an associate professor of psychology at Kent State University, and a team of scientists from several research centers analyzed memory tests taken by 150 people who weighed an average of 300 pounds. Many had several health problems, such as high blood pressure, type 2 diabetes and sleep apnea.

Of that group, 109 of them then had bariatric surgery — mostly gastric bypass surgery, which creates a smaller stomach and bypasses part of the small intestine. The other 41 obese patients did not have surgery.
The improved memory for the surgery patients likely is not solely due to improved blood pressure, because only a small number went from being classified as having hypertension to no longer having it, Gunstad says.

Here's another good reason to lose weight: It may improve your memory and concentration, new research suggests.
Scientists know that overweight and obese people are at a greater risk for memory problems and other cognitive disabilities, but the latest study is one of the first to indicate that substantial weight loss improves brain health.
John Gunstad, an associate professor of psychology at Kent State University, and a team of scientists from several research centers analyzed memory tests taken by 150 people who weighed an average of 300 pounds. Many had several health problems, such as high blood pressure, type 2 diabetes and sleep apnea.

Of that group, 109 of them then had bariatric surgery — mostly gastric bypass surgery, which creates a smaller stomach and bypasses part of the small intestine. The other 41 obese patients did not have surgery.
The improved memory for the surgery patients likely is not solely due to improved blood pressure, because only a small number went from being classified as having hypertension to no longer having it, Gunstad says.

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To lose weight, put a little spring in your step

When it comes to weight control, almost nothing is easier and cheaper than brisk walking.

Going for a walk every day can improve mood, increase energy, lower blood pressure and protect against diabetes, osteoporosis and cancer.

But to reap these benefits, you need to get the lead out and put some spring in your step.

It's not window shopping or taking a stroll in the park. Walk like you're late for the bus.

You should be able to carry on a conversation, but you'll be a little breathless when you talk, says Miriam Nelson, director of the John Hancock Research Center on Physical Activity, Nutrition and Obesity Prevention at Tufts University in Boston.

You should be able to feel that your heart rate is up. Keep in mind that a brisk walk for one person may be a stroll for another, she says.

Pace yourself. If you are just starting out with a walking program, you should try to work up to a pace of at least 3 mph, says Anne Lusk, a research associate at the Harvard School of Public Health.

Here's another way to look at it:

• Less than 3 mph is considered slow walking.

•More than 3 mph is considered brisk walking.

•More than 4 mph is considered very brisk walking.

When it comes to weight control, almost nothing is easier and cheaper than brisk walking.

Going for a walk every day can improve mood, increase energy, lower blood pressure and protect against diabetes, osteoporosis and cancer.

But to reap these benefits, you need to get the lead out and put some spring in your step.

It's not window shopping or taking a stroll in the park. Walk like you're late for the bus.

You should be able to carry on a conversation, but you'll be a little breathless when you talk, says Miriam Nelson, director of the John Hancock Research Center on Physical Activity, Nutrition and Obesity Prevention at Tufts University in Boston.

You should be able to feel that your heart rate is up. Keep in mind that a brisk walk for one person may be a stroll for another, she says.

Pace yourself. If you are just starting out with a walking program, you should try to work up to a pace of at least 3 mph, says Anne Lusk, a research associate at the Harvard School of Public Health.

Here's another way to look at it:

• Less than 3 mph is considered slow walking.

•More than 3 mph is considered brisk walking.

•More than 4 mph is considered very brisk walking.

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Differences in Behavior of Cat Breeds

Marchei P, Diverio S, Falocci N et al: Breed differences in behavioural response to challenging situations in kittens, Physiol Behav 102:276, 2011.
 

These researchers evaluated the behavioral responses of Oriental/Siamese/Abyssinian (OSA) kittens with Norwegian Forest (NF) kittens as part of an ongoing study investigating animal behavior. They observed kittens’ responses to a potentially threatening object (TO), in this case a metal spring spontaneously bouncing out of its container. Heart rates and behaviors were recorded, and showed that NF kittens exhibited an avoidance response to the TO, as well as high scores for exploration and escape attempts.  The OSA kittens had a more passive coping strategy, and low arousability predisposition. The researchers concluded that the variation in responses likely depended on different patterns of neurological development among breeds with a different strategy towards challenge – OSA kittens had a more passive coping strategy compared to the more active response (avoidance, escape) of NF kittens. [MK]

Related articles: 

Marchei P, Diverio S, Falocci N et al: Breed differences in behavioural development in kittens, Physiology & behavior 96:522, 2009.

More on cat health: Winn Feline Foundation

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Marchei P, Diverio S, Falocci N et al: Breed differences in behavioural response to challenging situations in kittens, Physiol Behav 102:276, 2011.
 

These researchers evaluated the behavioral responses of Oriental/Siamese/Abyssinian (OSA) kittens with Norwegian Forest (NF) kittens as part of an ongoing study investigating animal behavior. They observed kittens’ responses to a potentially threatening object (TO), in this case a metal spring spontaneously bouncing out of its container. Heart rates and behaviors were recorded, and showed that NF kittens exhibited an avoidance response to the TO, as well as high scores for exploration and escape attempts.  The OSA kittens had a more passive coping strategy, and low arousability predisposition. The researchers concluded that the variation in responses likely depended on different patterns of neurological development among breeds with a different strategy towards challenge – OSA kittens had a more passive coping strategy compared to the more active response (avoidance, escape) of NF kittens. [MK]

Related articles: 

Marchei P, Diverio S, Falocci N et al: Breed differences in behavioural development in kittens, Physiology & behavior 96:522, 2009.

More on cat health: Winn Feline Foundation

Join us on Facebook

Follow us on Twitter

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Turmeric: Nature’s Powerful Anti-Inflammatory

Some of the best Indian food I’ve ever tasted was cooked in London. I always knew that the British loved Indian cuisine and that they once held governance over the country. But what I didn’t know was that curry was introduced to Indian cuisine by the Brits! (Just a little fun fact to chew on).

In traditional cultures that are thousands of years old, like India, there are deep traditions of cooking daily meals with medicinal roots and herbs. These herbs act as preventive measures for sustaining good health, and prevention is the cornerstone of India’s traditional Ayurvedic medicine.

Turmeric is one such medicinal root that has made its way into a vast number of Indian recipes. Aside from your standard Chicken or Goat curries, there is a whole list of Indian dishes that contain flavorful thermogenic ingredients like cardamom, coriander, ginger, cloves, chili and turmeric. Not only are the recipes tasty, the ones containing turmeric are especially healthful.

Research by Sarker et al. notes its powerful anti-inflammatory, anti-tumor and antioxidant properties. Moreover, the U.S. National Library of Medicine and the National Institutes of Health have this to say: “Laboratory and animal research has demonstrated anti-inflammatory, antioxidant, and anti-cancer properties of turmeric and its constituent curcumin.”

Some of the best Indian food I’ve ever tasted was cooked in London. I always knew that the British loved Indian cuisine and that they once held governance over the country. But what I didn’t know was that curry was introduced to Indian cuisine by the Brits! (Just a little fun fact to chew on).

In traditional cultures that are thousands of years old, like India, there are deep traditions of cooking daily meals with medicinal roots and herbs. These herbs act as preventive measures for sustaining good health, and prevention is the cornerstone of India’s traditional Ayurvedic medicine.

Turmeric is one such medicinal root that has made its way into a vast number of Indian recipes. Aside from your standard Chicken or Goat curries, there is a whole list of Indian dishes that contain flavorful thermogenic ingredients like cardamom, coriander, ginger, cloves, chili and turmeric. Not only are the recipes tasty, the ones containing turmeric are especially healthful.

Research by Sarker et al. notes its powerful anti-inflammatory, anti-tumor and antioxidant properties. Moreover, the U.S. National Library of Medicine and the National Institutes of Health have this to say: “Laboratory and animal research has demonstrated anti-inflammatory, antioxidant, and anti-cancer properties of turmeric and its constituent curcumin.”

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How to Reduce Your Risk of Cancer By 50%

I have some vital information for you that can literally save your life, save you from dying from cancer; not just from getting cancer, but from dying from it. I came across this absolutely vital information while researching my new book called, Dark Deception, info which is just too important to keep under wraps until the book's release in a year's time.

Cancer is now the number one cause of death in the country, having surpassed heart disease a few years ago.

Please check out the graph in the video that illustrates the relationship between latitude, sun exposure and death rates from cancer. Remember the vertical axis shows the number of cancer-related deaths per 100,000, while the horizontal axis indicates latitude. It clearly shows that cancer-deaths go up significantly, the farther away from the equator one lives.

Here's why. With sun exposure, UVB radiation from the sun converts cholesterol to vitamin D, one of the most potent anticancer vitamins. See the connection? Please keep your vitamin D levels in a healthy range. If you're taking oral vitamin D in cod liver oil or a supplement, you need to measure your vitamin D blood levels to avoid overdosing. Take a simple blood test to help you keep your vitamin D levels in a safe, optimal range, and go to my vitamin D testing page for more details

While in Maui this winter, I heard a number of heartbreaking stories from folks there, who told me of close relatives who either had cancer, were dying from it or had died from it. How tragic! With this new information about vitamin D in mind, I said to them, "I don't know your relative." I asked, "But did they stay in the sun? Do they have a tan?", and even though some of these people lived in Maui, it seems every one of these people did not get much sun and were pale. This was a giant clue, empirically confirming what I was learning about sun exposure.

The best and safest way to get vitamin D is from the sun. The safe way to get sun exposure is to just go out enough so that your skin turns the very lightest pink. You'll also need enough of your skin exposed to sun. Exposing only your face and hands while going from office to car is not enough for conversion into vitamin D. We must remain sensible in our approach to this issue. This means: PLEASE DON'T GET SUNBURNED!

Bear in mind unique risk factors for dark-complexioned individuals. So if you're African-American, from the Middle East or India and live in America or Europe or in a very northern latitude, you're at very high risk for developing these cancers, as high as four times the risk. Darker skin serves as a filter, causing the need for two to five times as much sunlight as someone with very pale skin.

Also be careful about using most sunblocks as they are dangerous.If you are looking for a safe one I have researched this and recommend Active Full Spectrum Sun Block. If you can't easily find it I put it in my store for your convenience.

In light-skinned individuals, overexposure to sun can also be problematic.

Normally, skin cancer is not going to be the melanoma type, for which there are multiple causes. Follow the link below to learn more. But having sun exposure can increase the risk of other types of skin cancers, which while not as dangerous as melanoma, are easily avoided with cautious sun exposure

BOTTOM LINE: NEVER GET SUNBURNED!

Avoid commercial sun blocks, which contain toxic chemicals that enter your bloodstream through the skin, and follow the link below for more info and alternatives to these products.

If you have any questions at all about the relationship about sun and skin cancer please be sure to visit my article on that topic.

Stay informed. Have a healthy, careful, appropriate relationship with sunlight.

I have some vital information for you that can literally save your life, save you from dying from cancer; not just from getting cancer, but from dying from it. I came across this absolutely vital information while researching my new book called, Dark Deception, info which is just too important to keep under wraps until the book's release in a year's time.

Cancer is now the number one cause of death in the country, having surpassed heart disease a few years ago.

Please check out the graph in the video that illustrates the relationship between latitude, sun exposure and death rates from cancer. Remember the vertical axis shows the number of cancer-related deaths per 100,000, while the horizontal axis indicates latitude. It clearly shows that cancer-deaths go up significantly, the farther away from the equator one lives.

Here's why. With sun exposure, UVB radiation from the sun converts cholesterol to vitamin D, one of the most potent anticancer vitamins. See the connection? Please keep your vitamin D levels in a healthy range. If you're taking oral vitamin D in cod liver oil or a supplement, you need to measure your vitamin D blood levels to avoid overdosing. Take a simple blood test to help you keep your vitamin D levels in a safe, optimal range, and go to my vitamin D testing page for more details

While in Maui this winter, I heard a number of heartbreaking stories from folks there, who told me of close relatives who either had cancer, were dying from it or had died from it. How tragic! With this new information about vitamin D in mind, I said to them, "I don't know your relative." I asked, "But did they stay in the sun? Do they have a tan?", and even though some of these people lived in Maui, it seems every one of these people did not get much sun and were pale. This was a giant clue, empirically confirming what I was learning about sun exposure.

The best and safest way to get vitamin D is from the sun. The safe way to get sun exposure is to just go out enough so that your skin turns the very lightest pink. You'll also need enough of your skin exposed to sun. Exposing only your face and hands while going from office to car is not enough for conversion into vitamin D. We must remain sensible in our approach to this issue. This means: PLEASE DON'T GET SUNBURNED!

Bear in mind unique risk factors for dark-complexioned individuals. So if you're African-American, from the Middle East or India and live in America or Europe or in a very northern latitude, you're at very high risk for developing these cancers, as high as four times the risk. Darker skin serves as a filter, causing the need for two to five times as much sunlight as someone with very pale skin.

Also be careful about using most sunblocks as they are dangerous.If you are looking for a safe one I have researched this and recommend Active Full Spectrum Sun Block. If you can't easily find it I put it in my store for your convenience.

In light-skinned individuals, overexposure to sun can also be problematic.

Normally, skin cancer is not going to be the melanoma type, for which there are multiple causes. Follow the link below to learn more. But having sun exposure can increase the risk of other types of skin cancers, which while not as dangerous as melanoma, are easily avoided with cautious sun exposure

BOTTOM LINE: NEVER GET SUNBURNED!

Avoid commercial sun blocks, which contain toxic chemicals that enter your bloodstream through the skin, and follow the link below for more info and alternatives to these products.

If you have any questions at all about the relationship about sun and skin cancer please be sure to visit my article on that topic.

Stay informed. Have a healthy, careful, appropriate relationship with sunlight.

Read More