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Tuesday, January 25, 2011

Medical Treatment for Feline Hyperthyroidism


Hyperthyroidism is the most common endocrine disorder in middle-aged and older cats. Medical management with the antithyroid drug methimazole has become a popular option, either before surgery (thyroidectomy) or radioiodine treatment, or for long-term medical management. Carbimazole is rapidly metabolized to methimazole in vivo. This cross-over study of 6 normal cats compared a single oral dose of either a controlled-release carbimazole tablet or a sugar-coated methimazole tablet. Both formulations are approved for use in cats and were found to be well tolerated by the cats in the course of the study. In general, the pharmacokinetic values for the two treatments were similar when differences in effective methimazole dose were taken into consideration. Both drugs were reported to have relatively short plasma half-lives in the current study that would seem to support either once or twice daily dosing for either. Methimazole accumulates in the thyroid gland so that antithyroid effects extend beyond (possibly up to 24 hours) the duration of elevated plasma levels.  Therefore, the short half-life of 3 hours for both controlled-release carbimazole and sugar-coated methimazole tablets is consistent with current practice recommendations for divided daily dosing, although once-daily dosing may be appropriate for maintenance therapy in some cats. [VT]

Related articles:

More on cat health: Winn Feline Foundation Library

Hyperthyroidism is the most common endocrine disorder in middle-aged and older cats. Medical management with the antithyroid drug methimazole has become a popular option, either before surgery (thyroidectomy) or radioiodine treatment, or for long-term medical management. Carbimazole is rapidly metabolized to methimazole in vivo. This cross-over study of 6 normal cats compared a single oral dose of either a controlled-release carbimazole tablet or a sugar-coated methimazole tablet. Both formulations are approved for use in cats and were found to be well tolerated by the cats in the course of the study. In general, the pharmacokinetic values for the two treatments were similar when differences in effective methimazole dose were taken into consideration. Both drugs were reported to have relatively short plasma half-lives in the current study that would seem to support either once or twice daily dosing for either. Methimazole accumulates in the thyroid gland so that antithyroid effects extend beyond (possibly up to 24 hours) the duration of elevated plasma levels.  Therefore, the short half-life of 3 hours for both controlled-release carbimazole and sugar-coated methimazole tablets is consistent with current practice recommendations for divided daily dosing, although once-daily dosing may be appropriate for maintenance therapy in some cats. [VT]

Related articles:

More on cat health: Winn Feline Foundation Library
Read More


Sunday, January 23, 2011

Eating More Fruit and Vegetables Is Linked to a Lower Risk of Dying from Ischemic Heart Disease

A European study investigating the links between diet and disease has found that people who consume more fruit and vegetables have a lower risk of dying from ischaemic heart disease -- the most common form of heart disease and one of the leading causes of death in Europe. However, the authors point out that a higher fruit and vegetable intake occurs among people with other healthy eating habits and lifestyles, and that these factors could also be associated with the lower risk of dying from IHD.

The study is published online on January 19 in the European Heart Journal.

Data analysed from the European Prospective Investigation into Cancer and Nutrition (EPIC) Heart study has shown that people who ate at least eight portions of fruit and vegetables a day had a 22% lower risk of dying from IHD than did those who consumed fewer than three portions a day. A portion weighed 80 grams, equal to a small banana, a medium apple, or a small carrot.

Dr Francesca Crowe of the Cancer Epidemiology Unit at the University of Oxford, UK, and the first author of the paper by the EPIC study collaborators, said: "This study involved over 300,000 people in eight different European countries, with 1,636 deaths from IHD. It shows a 4% reduced risk of dying from IHD for each additional portion of fruit and vegetables consumed above the lowest intake of two portions. In other words, the risk of a fatal IHD for someone eating five portions of fruit and vegetables a day would be 4% lower compared to someone consuming four portions a day, and so on up to eight portions or more."

Ischaemic heart disease (IHD) is characterised by reduced blood supply to the heart; people suffering from it can develop angina, chest pains and have a heart attack.

The EPIC study started in 1992 and recruited participants from a total of ten European countries* until 2000. For the analysis of IHD deaths, data from eight countries for people aged between 40 and 85 were used. Participants answered questions about their diet at the time of entry to the study and other questions about health, socio-economic status and life-style, such as smoking, drinking and exercise habits. They were followed-up for an average of nearly eight and a half years.

The researchers found that the average intake of fruit and vegetables was five portions a day; people in Greece, Italy and Spain ate more, and those in Sweden ate less.

When analysing the data, the researchers made allowances for confounding factors such as differences in lifestyles and eating habits. However, the study could be limited by errors in measuring correctly people's fruit and vegetable intake as well as other aspects of their diet. In addition, the study had a higher proportion of women, which might not be generalisable to the wider European population.

Dr Crowe said: "The main message from this analysis is that, in this study, people who consume more fruits and vegetables have lower risk of dying from IHD. However, we need to be cautious in our interpretation of the results because we are unsure whether the association between fruit and vegetable intake and risk of IHD is due to some other component of diet or lifestyle.

"If we could understand, by means of well-designed intervention studies, the biological mechanisms that could underlie the association between fruits and vegetables and IHD, this might help to determine whether or not the relation between fruit and vegetables with IHD risk is causal."

In an accompanying editorial, Professor Sir Michael Marmot, director of the University College London (UCL) International Institute for Society and Health, head of the UCL Department of Epidemiology and Public Health, and chairman of the Commission on Social Determinants of Health, writes that it is difficult to reach firm conclusions about causation from results that show a 22% lower risk of dying from IHD (an odds ration of 0.78) in people who eat eight portions of fruit and vegetables a day.

He continues: "Such an odds ratio is, however, of huge practical importance. Cardiovascular disease is the most common cause of death. A reduction of 22% is huge. But... this reduction in mortality comes with consumption of eight portions a day, or 640g. Such a high consumption was found in only 18% of the men and women in these eight cohorts. There would need to be big shift in dietary patterns to achieve this healthy consumption of eight portions a day. It is worth trying to move in that direction. Reductions in cancers of several sites, in blood pressure and stroke, would add to this reduction in fatal CHD. Moving to a diet that emphasises fruit and vegetables is of great importance to public health."

*The ten countries include: Denmark, France, Germany, Greece, Italy, The Netherlands, Norway, Spain, Sweden and the United Kingdom. For the Heart component of the study, data from France and Norway were excluded due to the small number of IHD deaths at the end of the follow-up period.
A European study investigating the links between diet and disease has found that people who consume more fruit and vegetables have a lower risk of dying from ischaemic heart disease -- the most common form of heart disease and one of the leading causes of death in Europe. However, the authors point out that a higher fruit and vegetable intake occurs among people with other healthy eating habits and lifestyles, and that these factors could also be associated with the lower risk of dying from IHD.

The study is published online on January 19 in the European Heart Journal.

Data analysed from the European Prospective Investigation into Cancer and Nutrition (EPIC) Heart study has shown that people who ate at least eight portions of fruit and vegetables a day had a 22% lower risk of dying from IHD than did those who consumed fewer than three portions a day. A portion weighed 80 grams, equal to a small banana, a medium apple, or a small carrot.

Dr Francesca Crowe of the Cancer Epidemiology Unit at the University of Oxford, UK, and the first author of the paper by the EPIC study collaborators, said: "This study involved over 300,000 people in eight different European countries, with 1,636 deaths from IHD. It shows a 4% reduced risk of dying from IHD for each additional portion of fruit and vegetables consumed above the lowest intake of two portions. In other words, the risk of a fatal IHD for someone eating five portions of fruit and vegetables a day would be 4% lower compared to someone consuming four portions a day, and so on up to eight portions or more."

Ischaemic heart disease (IHD) is characterised by reduced blood supply to the heart; people suffering from it can develop angina, chest pains and have a heart attack.

The EPIC study started in 1992 and recruited participants from a total of ten European countries* until 2000. For the analysis of IHD deaths, data from eight countries for people aged between 40 and 85 were used. Participants answered questions about their diet at the time of entry to the study and other questions about health, socio-economic status and life-style, such as smoking, drinking and exercise habits. They were followed-up for an average of nearly eight and a half years.

The researchers found that the average intake of fruit and vegetables was five portions a day; people in Greece, Italy and Spain ate more, and those in Sweden ate less.

When analysing the data, the researchers made allowances for confounding factors such as differences in lifestyles and eating habits. However, the study could be limited by errors in measuring correctly people's fruit and vegetable intake as well as other aspects of their diet. In addition, the study had a higher proportion of women, which might not be generalisable to the wider European population.

Dr Crowe said: "The main message from this analysis is that, in this study, people who consume more fruits and vegetables have lower risk of dying from IHD. However, we need to be cautious in our interpretation of the results because we are unsure whether the association between fruit and vegetable intake and risk of IHD is due to some other component of diet or lifestyle.

"If we could understand, by means of well-designed intervention studies, the biological mechanisms that could underlie the association between fruits and vegetables and IHD, this might help to determine whether or not the relation between fruit and vegetables with IHD risk is causal."

In an accompanying editorial, Professor Sir Michael Marmot, director of the University College London (UCL) International Institute for Society and Health, head of the UCL Department of Epidemiology and Public Health, and chairman of the Commission on Social Determinants of Health, writes that it is difficult to reach firm conclusions about causation from results that show a 22% lower risk of dying from IHD (an odds ration of 0.78) in people who eat eight portions of fruit and vegetables a day.

He continues: "Such an odds ratio is, however, of huge practical importance. Cardiovascular disease is the most common cause of death. A reduction of 22% is huge. But... this reduction in mortality comes with consumption of eight portions a day, or 640g. Such a high consumption was found in only 18% of the men and women in these eight cohorts. There would need to be big shift in dietary patterns to achieve this healthy consumption of eight portions a day. It is worth trying to move in that direction. Reductions in cancers of several sites, in blood pressure and stroke, would add to this reduction in fatal CHD. Moving to a diet that emphasises fruit and vegetables is of great importance to public health."

*The ten countries include: Denmark, France, Germany, Greece, Italy, The Netherlands, Norway, Spain, Sweden and the United Kingdom. For the Heart component of the study, data from France and Norway were excluded due to the small number of IHD deaths at the end of the follow-up period.
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Healthy gums may lead to healthy lungs

CHICAGO – January 18, 2011 – Maintaining periodontal health may contribute to a healthy respiratory system, according to research published in the Journal of Periodontology. A new study suggests that periodontal disease may increase the risk for respiratory infections, such as chronic obstructive pulmonary disease (COPD) and pneumonia. These infections, which are caused when bacteria from the upper throat are inhaled into the lower respiratory tract, can be severely debilitating and are one of the leading causes of death in the U.S.

The study included 200 participants between the ages of 20 and 60 with at least 20 natural teeth. Half of the participants were hospitalized patients with a respiratory disease such as pneumonia, COPD, or acute bronchitis, and the other half were healthy control subjects with no history of respiratory disease. Each participant underwent a comprehensive oral evaluation to measure periodontal health status.

The study found that patients with respiratory diseases had worse periodontal health than the control group, suggesting a relationship between respiratory disease and periodontal disease. Researchers suspect that the presence of oral pathogens associated with periodontal disease may increase a patient's risk of developing or exacerbating respiratory disease. However, the study authors note that additional studies are needed to more conclusively understand this link.

"Pulmonary diseases can be severely disabling and debilitating," says Donald S. Clem, DDS, President of the American Academy of Periodontology. "By working with your dentist or periodontist, you may actually be able to prevent or diminish the progression of harmful diseases such as pneumonia or COPD. This study provides yet another example of how periodontal health plays a role in keeping other systems of the body healthy."

Periodontal disease is a chronic inflammatory disease that affects the gum tissue and other structures supporting the teeth. Previous research has associated gum disease with other chronic inflammatory diseases such as diabetes, cardiovascular disease, and rheumatoid arthritis.

Dr. Clem stressed the importance of routine oral care in helping to prevent periodontal disease. "Taking good care of your periodontal health involves daily tooth brushing and flossing. You should also expect to get a comprehensive periodontal evaluation every year," he advised. A dental professional, such as a periodontist, a specialist in the diagnosis, treatment and prevention of gum disease, can conduct a comprehensive exam to assess your periodontal disease status.
CHICAGO – January 18, 2011 – Maintaining periodontal health may contribute to a healthy respiratory system, according to research published in the Journal of Periodontology. A new study suggests that periodontal disease may increase the risk for respiratory infections, such as chronic obstructive pulmonary disease (COPD) and pneumonia. These infections, which are caused when bacteria from the upper throat are inhaled into the lower respiratory tract, can be severely debilitating and are one of the leading causes of death in the U.S.

The study included 200 participants between the ages of 20 and 60 with at least 20 natural teeth. Half of the participants were hospitalized patients with a respiratory disease such as pneumonia, COPD, or acute bronchitis, and the other half were healthy control subjects with no history of respiratory disease. Each participant underwent a comprehensive oral evaluation to measure periodontal health status.

The study found that patients with respiratory diseases had worse periodontal health than the control group, suggesting a relationship between respiratory disease and periodontal disease. Researchers suspect that the presence of oral pathogens associated with periodontal disease may increase a patient's risk of developing or exacerbating respiratory disease. However, the study authors note that additional studies are needed to more conclusively understand this link.

"Pulmonary diseases can be severely disabling and debilitating," says Donald S. Clem, DDS, President of the American Academy of Periodontology. "By working with your dentist or periodontist, you may actually be able to prevent or diminish the progression of harmful diseases such as pneumonia or COPD. This study provides yet another example of how periodontal health plays a role in keeping other systems of the body healthy."

Periodontal disease is a chronic inflammatory disease that affects the gum tissue and other structures supporting the teeth. Previous research has associated gum disease with other chronic inflammatory diseases such as diabetes, cardiovascular disease, and rheumatoid arthritis.

Dr. Clem stressed the importance of routine oral care in helping to prevent periodontal disease. "Taking good care of your periodontal health involves daily tooth brushing and flossing. You should also expect to get a comprehensive periodontal evaluation every year," he advised. A dental professional, such as a periodontist, a specialist in the diagnosis, treatment and prevention of gum disease, can conduct a comprehensive exam to assess your periodontal disease status.
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Wednesday, January 19, 2011

Four Cups of Coffee a Day Slash Diabetes Risk in Half

Drinking four cups of coffee every day can decrease a woman's risk of developing Type 2 diabetes by more than half, according to a new study.

And the researchers say they've uncovered the reason why the new findings and other research have suggested a link between java and diabetes. They found that coffee raises the amount of sex hormone-binding globulin (SHBG) in the blood, and higher levels of SHBG are known to lower the risk of developing Type 2 diabetes.

It's likely something in the coffee besides the caffeine — or something about coffee drinkers that confers these protective effects, said James D. Lane, an associate research professor at Duke University Medical Center, who was not involved with the study.

Although, "it's impressive to find these new things," Lane told MyHealthNewsDaily, more research is needed to confirm the link.

The study is published in this month's issue of the journal Diabetes.

The more you drink, the lower your diabetes risk

In the new study, researchers from the University of California, Los Angeles, compared the medical histories and coffee-drinking habits of 359 women who had diabetes with those of 359 healthy women over 10 years. They used information from the Women's Health Study, run by the National Institutes of Health.

Women who drank four cups of caffeinated coffee a day had higher levels of SHBG and were 56 percent less likely to develop Type 2 diabetes than women who don't drink coffee, the researchers found.

And the more coffee the women drank, the more their risk of developing Type 2 diabetes dropped, the study said.

Furthermore, when the researchers took into account the women's SHBG levels, they found that it was coffee's effect on SHBG levels that was making the difference in diabetes risk. SHBG regulates the levels of sex hormones in the blood.

Previous work had suggested a link between SHBG and diabetes. A 2009 study in the New England Journal of Medicine, done by one of the researchers of the new study, showed that higher levels of SHBG in the blood were associated with a lower risk of developing Type 2 diabetes.

Past evidence of protection

A causal link between SHBG, diabetes and coffee — which contains many compounds — is not clear, Lane said. For example, he pointed to a 2004 study in journal Diabetes Care, which showed that caffeine is harmful to people with Type 2 diabetes, because it hinders the breakdown of glucose.

But other past studies have shown that something in coffee seems to have a protective effect against Type 2 diabetes, he said.

A 2006 study in the journal Archives of Internal Medicine of 28,812 women found that those who drank six cups of decaffeinated coffee a day had a 22 percent lower risk of developing Type 2 diabetes than those who don't drink any coffee. Caffeinated coffee also seemed to have a protective effect, though not as strong as that of decaffeinated coffee, the researchers said.

And a 2009 study in the same journal showed that each daily cup of coffee or tea cut the risk of developing diabetes by 7 percent.
Drinking four cups of coffee every day can decrease a woman's risk of developing Type 2 diabetes by more than half, according to a new study.

And the researchers say they've uncovered the reason why the new findings and other research have suggested a link between java and diabetes. They found that coffee raises the amount of sex hormone-binding globulin (SHBG) in the blood, and higher levels of SHBG are known to lower the risk of developing Type 2 diabetes.

It's likely something in the coffee besides the caffeine — or something about coffee drinkers that confers these protective effects, said James D. Lane, an associate research professor at Duke University Medical Center, who was not involved with the study.

Although, "it's impressive to find these new things," Lane told MyHealthNewsDaily, more research is needed to confirm the link.

The study is published in this month's issue of the journal Diabetes.

The more you drink, the lower your diabetes risk

In the new study, researchers from the University of California, Los Angeles, compared the medical histories and coffee-drinking habits of 359 women who had diabetes with those of 359 healthy women over 10 years. They used information from the Women's Health Study, run by the National Institutes of Health.

Women who drank four cups of caffeinated coffee a day had higher levels of SHBG and were 56 percent less likely to develop Type 2 diabetes than women who don't drink coffee, the researchers found.

And the more coffee the women drank, the more their risk of developing Type 2 diabetes dropped, the study said.

Furthermore, when the researchers took into account the women's SHBG levels, they found that it was coffee's effect on SHBG levels that was making the difference in diabetes risk. SHBG regulates the levels of sex hormones in the blood.

Previous work had suggested a link between SHBG and diabetes. A 2009 study in the New England Journal of Medicine, done by one of the researchers of the new study, showed that higher levels of SHBG in the blood were associated with a lower risk of developing Type 2 diabetes.

Past evidence of protection

A causal link between SHBG, diabetes and coffee — which contains many compounds — is not clear, Lane said. For example, he pointed to a 2004 study in journal Diabetes Care, which showed that caffeine is harmful to people with Type 2 diabetes, because it hinders the breakdown of glucose.

But other past studies have shown that something in coffee seems to have a protective effect against Type 2 diabetes, he said.

A 2006 study in the journal Archives of Internal Medicine of 28,812 women found that those who drank six cups of decaffeinated coffee a day had a 22 percent lower risk of developing Type 2 diabetes than those who don't drink any coffee. Caffeinated coffee also seemed to have a protective effect, though not as strong as that of decaffeinated coffee, the researchers said.

And a 2009 study in the same journal showed that each daily cup of coffee or tea cut the risk of developing diabetes by 7 percent.
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Curcumin may relieve pain, inflammation for osteoarthritis patients

A study published in Alternative Medicine Review shows that Meriva, an Indena proprietary formulation of curcumin with soy phospholipids, has been shown to relieve pain and increase mobility in patients with osteoarthritis as well as reduce a series of inflammatory markers.

In the study, 100 patients with X-ray confirmed osteoarthritis (OA) were divided in two groups. The first one was managed using the “best available treatment” and the second group used the best available treatment plus Meriva, at a dosage corresponding to 200 mg curcumin/day.

The results showed that the Meriva-treated group had a statistically significant reduction in all primary clinical end-points, the Western Ontario and McMaster Universities (WOMAC) score, the Karnofsky Performance Scale, and the treadmill walking performance test. These results were complemented by the evaluation of a series of inflammatory markers, soluble vascular cell adhesion molecule (sVCAM)-1, and erythrocyte sedimentation rate [ESR]), which also showed a marked reduction in the Meriva-treated group, while no significant variation was observed in the “best available treatment” group.

Commenting on the results of the study, Giovanni Appendino, Professor of Organic Chemistry at the University of Eastern Piedmont and Indena Scientific Advisor, said “this study represents the most ambitious attempt, to date, to evaluate the clinical efficacy and safety of curcumin as an anti-inflammatory agent. Although no direct comparison study of Meriva versus NSAIDs (nonsteroidal anti-inflammatory drugs) has been conducted, the decreased use of these drugs observed in the treatment group provides a rationale for evaluating whether the biochemical improvement in the inflammatory status associated with Meriva could eventually translate to a phase out of NSAIDs use, at least for mild-to-moderate OA.”
A study published in Alternative Medicine Review shows that Meriva, an Indena proprietary formulation of curcumin with soy phospholipids, has been shown to relieve pain and increase mobility in patients with osteoarthritis as well as reduce a series of inflammatory markers.

In the study, 100 patients with X-ray confirmed osteoarthritis (OA) were divided in two groups. The first one was managed using the “best available treatment” and the second group used the best available treatment plus Meriva, at a dosage corresponding to 200 mg curcumin/day.

The results showed that the Meriva-treated group had a statistically significant reduction in all primary clinical end-points, the Western Ontario and McMaster Universities (WOMAC) score, the Karnofsky Performance Scale, and the treadmill walking performance test. These results were complemented by the evaluation of a series of inflammatory markers, soluble vascular cell adhesion molecule (sVCAM)-1, and erythrocyte sedimentation rate [ESR]), which also showed a marked reduction in the Meriva-treated group, while no significant variation was observed in the “best available treatment” group.

Commenting on the results of the study, Giovanni Appendino, Professor of Organic Chemistry at the University of Eastern Piedmont and Indena Scientific Advisor, said “this study represents the most ambitious attempt, to date, to evaluate the clinical efficacy and safety of curcumin as an anti-inflammatory agent. Although no direct comparison study of Meriva versus NSAIDs (nonsteroidal anti-inflammatory drugs) has been conducted, the decreased use of these drugs observed in the treatment group provides a rationale for evaluating whether the biochemical improvement in the inflammatory status associated with Meriva could eventually translate to a phase out of NSAIDs use, at least for mild-to-moderate OA.”
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Tuesday, January 18, 2011

Laryngeal Paralysis in Cats


Laryngeal paralysis is the failure of one or both arytenoid cartilages to open outward (abduct) during inspiration, thereby creating an upper airway obstruction. The syndrome has been well documented in dogs. Congenital and acquired laryngeal paralyses have also been sporadically reported in cats. This is a retrospective study of fourteen cats diagnosed with laryngeal paralysis treated by unilateral arytenoid lateralization surgery. Clinical signs noted on physical examination included dyspnea, inspiratory stridor, wheezing, change in voice, lethargy, anorexia, open mouth breathing, hind-limb weakness and dysphagia. The median age of cats was estimated to be 16 years. The cause of the laryngeal paralysis is often elusive. In this study, two cases developed laryngeal paralysis subsequent to trauma. Polyneuropathy and polymyopathy have been associated with laryngeal paralysis and five cats presented with progressive neuromuscular weakness or signs suggestive of this type of etiology. In cats that have signs of a potential polyneuropathy/myopathy, a full neurological evaluation is warranted. Seven cats had no identifiable definitive cause for laryngeal paralysis; therefore they were diagnosed as idiopathic in nature. Intraoperative and postoperative surgical complications were seen in 21% and 50% of the cases, respectively. No cats had recurrence of clinical signs. Based on these results, unilateral arytenoid lateralization appears to be a suitable method for treatment of laryngeal paralysis in cats. [VT]

Related articles:

More on cat health: Winn Feline Foundation Library

Laryngeal paralysis is the failure of one or both arytenoid cartilages to open outward (abduct) during inspiration, thereby creating an upper airway obstruction. The syndrome has been well documented in dogs. Congenital and acquired laryngeal paralyses have also been sporadically reported in cats. This is a retrospective study of fourteen cats diagnosed with laryngeal paralysis treated by unilateral arytenoid lateralization surgery. Clinical signs noted on physical examination included dyspnea, inspiratory stridor, wheezing, change in voice, lethargy, anorexia, open mouth breathing, hind-limb weakness and dysphagia. The median age of cats was estimated to be 16 years. The cause of the laryngeal paralysis is often elusive. In this study, two cases developed laryngeal paralysis subsequent to trauma. Polyneuropathy and polymyopathy have been associated with laryngeal paralysis and five cats presented with progressive neuromuscular weakness or signs suggestive of this type of etiology. In cats that have signs of a potential polyneuropathy/myopathy, a full neurological evaluation is warranted. Seven cats had no identifiable definitive cause for laryngeal paralysis; therefore they were diagnosed as idiopathic in nature. Intraoperative and postoperative surgical complications were seen in 21% and 50% of the cases, respectively. No cats had recurrence of clinical signs. Based on these results, unilateral arytenoid lateralization appears to be a suitable method for treatment of laryngeal paralysis in cats. [VT]

Related articles:

More on cat health: Winn Feline Foundation Library
Read More


Monday, January 17, 2011

Lifting a Veil of Fear to See a Few Benefits of Fever

Fever is common, but fever is complicated. It brings up science and emotion, comfort and calculation.

I know fever is a signal that the immune system is working well. And as a parent, I know there is something primal and frightening about a feverish child in the night.

So those middle-of-the-night calls from worried parents, so frequent in every pediatric practice, can be less than straightforward. A recent paper in The Journal of the American Medical Association pointed out one reason, and a longstanding discussion about parental perceptions reminds us of the emotional context.

The JAMA study looked at over-the-counter medications for children, including those marketed for treating pain and fever: how they are labeled, and whether the droppers and cups and marked spoons in the packages properly reflect the doses recommended on the labels.

The article concluded that many medications are not labeled clearly, that some provide no dosing instrument, and that the instruments, if included, are not marked consistently. (A dosing chart might recommend 1.5 milliliters, but the dropper has no “1.5 ml” mark.)

“Basically, the main message of the paper is that the instructions on the boxes and bottles of over-the-counter medications are really confusing,” said the lead author, Dr. H. Shonna Yin of New York University Medical Center, who is a colleague of mine and an assistant professor of pediatrics.

Too small a dose of an antipyretic (fever medicine) may be ineffective; too much can be toxic. But the dose depends on the child’s weight, which of course changes over time, and on the concentration of the medicine, which depends on whether it is acetaminophen or ibuprofen, children’s liquid or infant drops.

“We always make them get the bottle,” said Kathleen Martinez, a pediatric nurse practitioner who is clinical coordinator of the After Hours Telephone Care Program at the Children’s Hospital in Aurora, Colo. “What do you have at home? Is it the ibuprofen infant drops or the children’s? Have the bottle in hand and verify the concentration.

“And then we have to verify the instrument, and then we give the right dose based on weight. It’s time-consuming, and then of course it changes with the weight, so the poor parents have to call back.”

Concerns about fever — how worried should I be, and how much medicine should I give? — account for many of the calls that parents make at night to their children’s doctors. For me, these tricky measurement questions evoke memories of many conversations, often from a crowded, noisy place (my own child’s Little League game, the supermarket), trying to answer a question about a small child with fever.

One recent night, I talked to the mother of a toddler with fever and abdominal pain. I was more worried about the pain, and about whether he was drinking enough to stay hydrated; she was more worried about the fever, and no matter what I asked she kept coming back to that number on the thermometer.

Finally, I got so worried the child was dehydrated that I told her to go to the emergency room. And when she got there, she told them she was scared because the child had a high fever.

Fever can indeed be scary, and any fever in an infant younger than 3 months is cause for major concern because of the risk of serious bacterial infections. But in general, in older children who do not look very distressed, fever is positive evidence of an active immune system, revved up and helping an array of immunological processes work more effectively.

Of course, that may not be reassuring to a parent whose child’s temperature is spiking at midnight. (Fevers tend to go up in the late afternoon and evening, as do normal body temperatures.)

In 1980, Dr. Barton D. Schmitt, a professor of pediatrics at the University of Colorado School of Medicine, published a now classic article about what he termed “fever phobia.” Many parents, he wrote, believed that untreated fevers might rise to critical levels and that even moderate and low-grade fevers could have serious neurological effects (that is, as parents we tend to suspect that our children’s brains may melt).

A group at Johns Hopkins revisited Dr. Schmitt’s work in 2001, publishing a paper in the journal Pediatrics, “Fever Phobia Revisited: Have Parental Misconceptions About Fever Changed in 20 Years?” Their conclusion was that the fears and misconceptions persisted.

In fact, fever does not harm the brain or the body, though it does increase the need for fluids. And even untreated, fevers rarely rise higher than 104 or 105 degrees.

As many as 5 percent of children are at risk for seizures with fever. These seizures can be terrifying to watch but generally are not harmful and do not cause epilepsy. Still, a child who has a first febrile seizure should be checked by a physician. (These seizures tend to run in families, and children who have had one may well have another.)

“Parents are telling us that they’re worried that fever can cause brain damage or even death in their children,” said Dr. Michael Crocetti, an assistant professor of pediatrics at Johns Hopkins and lead author of the 2001 study. “I’ve been doing this for a long time, and it seems to me that even though I do a tremendous amount of education about fever, its role in illness, its benefit in illness, it doesn’t seem to be something they keep hold of from visit to visit.”

Dr. Janet Serwint, another author of the study and a professor of pediatrics at Johns Hopkins, agreed. “I personally think there should be much more education about this at well visits,” she told me, adding that parents need to understand “the helpfulness of fever — how fever actually is a well-orchestrated healthy response of our body.”

Other studies have looked at attitudes among medical personnel, who can be just as worried about fever as parents.
Fever is common, but fever is complicated. It brings up science and emotion, comfort and calculation.

I know fever is a signal that the immune system is working well. And as a parent, I know there is something primal and frightening about a feverish child in the night.

So those middle-of-the-night calls from worried parents, so frequent in every pediatric practice, can be less than straightforward. A recent paper in The Journal of the American Medical Association pointed out one reason, and a longstanding discussion about parental perceptions reminds us of the emotional context.

The JAMA study looked at over-the-counter medications for children, including those marketed for treating pain and fever: how they are labeled, and whether the droppers and cups and marked spoons in the packages properly reflect the doses recommended on the labels.

The article concluded that many medications are not labeled clearly, that some provide no dosing instrument, and that the instruments, if included, are not marked consistently. (A dosing chart might recommend 1.5 milliliters, but the dropper has no “1.5 ml” mark.)

“Basically, the main message of the paper is that the instructions on the boxes and bottles of over-the-counter medications are really confusing,” said the lead author, Dr. H. Shonna Yin of New York University Medical Center, who is a colleague of mine and an assistant professor of pediatrics.

Too small a dose of an antipyretic (fever medicine) may be ineffective; too much can be toxic. But the dose depends on the child’s weight, which of course changes over time, and on the concentration of the medicine, which depends on whether it is acetaminophen or ibuprofen, children’s liquid or infant drops.

“We always make them get the bottle,” said Kathleen Martinez, a pediatric nurse practitioner who is clinical coordinator of the After Hours Telephone Care Program at the Children’s Hospital in Aurora, Colo. “What do you have at home? Is it the ibuprofen infant drops or the children’s? Have the bottle in hand and verify the concentration.

“And then we have to verify the instrument, and then we give the right dose based on weight. It’s time-consuming, and then of course it changes with the weight, so the poor parents have to call back.”

Concerns about fever — how worried should I be, and how much medicine should I give? — account for many of the calls that parents make at night to their children’s doctors. For me, these tricky measurement questions evoke memories of many conversations, often from a crowded, noisy place (my own child’s Little League game, the supermarket), trying to answer a question about a small child with fever.

One recent night, I talked to the mother of a toddler with fever and abdominal pain. I was more worried about the pain, and about whether he was drinking enough to stay hydrated; she was more worried about the fever, and no matter what I asked she kept coming back to that number on the thermometer.

Finally, I got so worried the child was dehydrated that I told her to go to the emergency room. And when she got there, she told them she was scared because the child had a high fever.

Fever can indeed be scary, and any fever in an infant younger than 3 months is cause for major concern because of the risk of serious bacterial infections. But in general, in older children who do not look very distressed, fever is positive evidence of an active immune system, revved up and helping an array of immunological processes work more effectively.

Of course, that may not be reassuring to a parent whose child’s temperature is spiking at midnight. (Fevers tend to go up in the late afternoon and evening, as do normal body temperatures.)

In 1980, Dr. Barton D. Schmitt, a professor of pediatrics at the University of Colorado School of Medicine, published a now classic article about what he termed “fever phobia.” Many parents, he wrote, believed that untreated fevers might rise to critical levels and that even moderate and low-grade fevers could have serious neurological effects (that is, as parents we tend to suspect that our children’s brains may melt).

A group at Johns Hopkins revisited Dr. Schmitt’s work in 2001, publishing a paper in the journal Pediatrics, “Fever Phobia Revisited: Have Parental Misconceptions About Fever Changed in 20 Years?” Their conclusion was that the fears and misconceptions persisted.

In fact, fever does not harm the brain or the body, though it does increase the need for fluids. And even untreated, fevers rarely rise higher than 104 or 105 degrees.

As many as 5 percent of children are at risk for seizures with fever. These seizures can be terrifying to watch but generally are not harmful and do not cause epilepsy. Still, a child who has a first febrile seizure should be checked by a physician. (These seizures tend to run in families, and children who have had one may well have another.)

“Parents are telling us that they’re worried that fever can cause brain damage or even death in their children,” said Dr. Michael Crocetti, an assistant professor of pediatrics at Johns Hopkins and lead author of the 2001 study. “I’ve been doing this for a long time, and it seems to me that even though I do a tremendous amount of education about fever, its role in illness, its benefit in illness, it doesn’t seem to be something they keep hold of from visit to visit.”

Dr. Janet Serwint, another author of the study and a professor of pediatrics at Johns Hopkins, agreed. “I personally think there should be much more education about this at well visits,” she told me, adding that parents need to understand “the helpfulness of fever — how fever actually is a well-orchestrated healthy response of our body.”

Other studies have looked at attitudes among medical personnel, who can be just as worried about fever as parents.
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