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Monday, June 14, 2010

Hip Exercises Found Effective at Reducing, Eliminating Common Knee Pain in Runners, Study Suggests

A twice weekly hip strengthening regimen performed for six weeks proved surprisingly effective at reducing -- and in some cases eliminating -- knee pain referred to as patellofemoral pain (PFP) in female runners.
The study by Tracy Dierks, assistant professor in the Department of Physical Therapy at Indiana University-Purdue University Indianapolis, was based on the theory that stronger hips would correct running form errors that contribute to PFP, even though study participants were given no instruction in gait training. The study used a pain scale of 0 to 10, with 3 representing the onset of pain and 7 representing very strong pain -- the point at which the runners normally stop running because the pain is too great. The injured runners began the six-week trial registering pain of 7 when they ran on a treadmill and finished the study period registering pain levels of 2 or lower; i.e. no onset of pain.

"I wasn't expecting such huge reductions, to be honest," Dierks said. "We've had a couple of runners who have been at level 2, but the overwhelming majority have been a 2 or below."

PFP, one of the most common running injuries, is caused when the thigh bone rubs against the back of the knee cap. Runners with PFP typically do not feel pain when they begin running, but once the pain begins, it gets increasingly worse. Once they stop running, the pain goes away almost immediately. Dierks said studies indicate PFP essentially wears away cartilage and can have the same effect as osteoarthritis. His study participants showed many of the classic signs of PFP, the most prominent being their knees collapsing inward when running or doing a squat exercise move.

The pilot study thus far involved five runners and a control group that comprised another four runners. Hip strength measurements were taken before and after the runners in the control group maintained their normal running schedule for six weeks. Hip strength measurements were taken for all of the runners before and after the next six-week period in which they all performed the hip-strengthening exercises. The exercises, performed twice a week for around 30 to 45 minutes, involved single-leg squats and exercises with a resistance band, all exercises that can be performed at home. This study is part of an ongoing study involving hip exercises and PFP pain, with 11 runners successfully using the intervention. Dierks said he plans to seek funding to test the exercises on a larger group of runners.

Earlier research had focused on the feet as a possible root of PFP, with studies only recently looking more closely at the hips. Dierks said studies have found an association between PFP in women and weak hips, but his study is the first to test a possible treatment. He noted that PFP is considered "multi-factorial," so his study is examining one of several possible causes of the pain.
A twice weekly hip strengthening regimen performed for six weeks proved surprisingly effective at reducing -- and in some cases eliminating -- knee pain referred to as patellofemoral pain (PFP) in female runners.
The study by Tracy Dierks, assistant professor in the Department of Physical Therapy at Indiana University-Purdue University Indianapolis, was based on the theory that stronger hips would correct running form errors that contribute to PFP, even though study participants were given no instruction in gait training. The study used a pain scale of 0 to 10, with 3 representing the onset of pain and 7 representing very strong pain -- the point at which the runners normally stop running because the pain is too great. The injured runners began the six-week trial registering pain of 7 when they ran on a treadmill and finished the study period registering pain levels of 2 or lower; i.e. no onset of pain.

"I wasn't expecting such huge reductions, to be honest," Dierks said. "We've had a couple of runners who have been at level 2, but the overwhelming majority have been a 2 or below."

PFP, one of the most common running injuries, is caused when the thigh bone rubs against the back of the knee cap. Runners with PFP typically do not feel pain when they begin running, but once the pain begins, it gets increasingly worse. Once they stop running, the pain goes away almost immediately. Dierks said studies indicate PFP essentially wears away cartilage and can have the same effect as osteoarthritis. His study participants showed many of the classic signs of PFP, the most prominent being their knees collapsing inward when running or doing a squat exercise move.

The pilot study thus far involved five runners and a control group that comprised another four runners. Hip strength measurements were taken before and after the runners in the control group maintained their normal running schedule for six weeks. Hip strength measurements were taken for all of the runners before and after the next six-week period in which they all performed the hip-strengthening exercises. The exercises, performed twice a week for around 30 to 45 minutes, involved single-leg squats and exercises with a resistance band, all exercises that can be performed at home. This study is part of an ongoing study involving hip exercises and PFP pain, with 11 runners successfully using the intervention. Dierks said he plans to seek funding to test the exercises on a larger group of runners.

Earlier research had focused on the feet as a possible root of PFP, with studies only recently looking more closely at the hips. Dierks said studies have found an association between PFP in women and weak hips, but his study is the first to test a possible treatment. He noted that PFP is considered "multi-factorial," so his study is examining one of several possible causes of the pain.
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Diabetes may double cancer risk in women

Type 2 adult-onset diabetes causes insulin-like hormones to circulate through the body. A new study finds this has a surprisingly positive effect on reducing the rate of prostate cancer in men, but is bad news for women: Type 2 diabetes may double the risk of female genital and other cancers.
The new study, led by Dr. Gabriel Chodick and Dr. Varda Shalev of Tel Aviv University's Department of Epidemiology and Preventive Medicine at the Sackler Faculty of Medicine, is not the first to report such a risk. But it's one of the largest to confirm these findings, and it's the first to determine the statistical differences in cancer risks for men and women.

Recently published in the journal Cancer Causes & Control, the Tel Aviv University study looked at 16,721 diabetics, differentiating between men and women and defining the relative cancer risks for each group. When the study began in 2000, none of the subjects had a history of cancer. Over the following eight years, the researchers documented 1,639 cases of different cancers among people with diabetes, and compared them to occurrences of the same cancers in the healthy non-diabetic population - a sample of 83,874 people.

"For men, this study is good news," says Dr. Chodick. The study demonstrates that diabetes actually appears to have a preventative effect on conditions like prostate cancer, reducing the risk of cancers associated with insulin-like hormones by a whopping 47 percent. But the opposite is true for women, he continues. "The interaction of diabetes and female hormones appears to exaggerate the risk, and make certain organs like the uterus and ovaries more receptive to certain kinds of cancer."

While the news is something for female diabetics and their practitioners to take into consideration, there's no cause for panic, Dr. Chodick notes. Although colon and ovarian cancers are serious, their overall risk in women is generally quite low. However, he stresses that physicians should take the research into account when assessing the long-term health histories of their patients.

Dr. Chodick encourages diabetic women to be screened for colon cancer earlier and more often than those in the general population. As the occurrence of diabetes in America rises, primarily brought on by an unhealthy lifestyle, such screenings can save lives.

Type 2 diabetes, which is characterized by high blood glucose and an insulin deficiency, normally occurs in adulthood, and it can often be managed with a healthy diet, exercise, and oral medications. It affects more than 10% of all women in America over the age of 20, according to the American Diabetes Association.

Of course, wherever possible, the best approach is to avoid diabetes entirely, says Dr. Chodick, with the help of a high-fiber, low-carbohydrate diet combined with exercise.
Type 2 adult-onset diabetes causes insulin-like hormones to circulate through the body. A new study finds this has a surprisingly positive effect on reducing the rate of prostate cancer in men, but is bad news for women: Type 2 diabetes may double the risk of female genital and other cancers.
The new study, led by Dr. Gabriel Chodick and Dr. Varda Shalev of Tel Aviv University's Department of Epidemiology and Preventive Medicine at the Sackler Faculty of Medicine, is not the first to report such a risk. But it's one of the largest to confirm these findings, and it's the first to determine the statistical differences in cancer risks for men and women.

Recently published in the journal Cancer Causes & Control, the Tel Aviv University study looked at 16,721 diabetics, differentiating between men and women and defining the relative cancer risks for each group. When the study began in 2000, none of the subjects had a history of cancer. Over the following eight years, the researchers documented 1,639 cases of different cancers among people with diabetes, and compared them to occurrences of the same cancers in the healthy non-diabetic population - a sample of 83,874 people.

"For men, this study is good news," says Dr. Chodick. The study demonstrates that diabetes actually appears to have a preventative effect on conditions like prostate cancer, reducing the risk of cancers associated with insulin-like hormones by a whopping 47 percent. But the opposite is true for women, he continues. "The interaction of diabetes and female hormones appears to exaggerate the risk, and make certain organs like the uterus and ovaries more receptive to certain kinds of cancer."

While the news is something for female diabetics and their practitioners to take into consideration, there's no cause for panic, Dr. Chodick notes. Although colon and ovarian cancers are serious, their overall risk in women is generally quite low. However, he stresses that physicians should take the research into account when assessing the long-term health histories of their patients.

Dr. Chodick encourages diabetic women to be screened for colon cancer earlier and more often than those in the general population. As the occurrence of diabetes in America rises, primarily brought on by an unhealthy lifestyle, such screenings can save lives.

Type 2 diabetes, which is characterized by high blood glucose and an insulin deficiency, normally occurs in adulthood, and it can often be managed with a healthy diet, exercise, and oral medications. It affects more than 10% of all women in America over the age of 20, according to the American Diabetes Association.

Of course, wherever possible, the best approach is to avoid diabetes entirely, says Dr. Chodick, with the help of a high-fiber, low-carbohydrate diet combined with exercise.
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Omega-3 may protect against hearing loss: Study

Increased intakes of omega-3 fatty acids, and the fish that provide them, may reduce the risk of age-related hearing loss, says a new study from the University of Sydney.

At least two servings of fish per week was associated with a 42 per cent reduction in the risk of hearing loss in over 50 year-olds, compared with people who average less than one serving per week, according to findings published in the American Journal of Clinical Nutrition.

Similar reductions were observed with intakes of long-chain omega-3 fatty acids, with increasing intakes associated with 14 per cent reductions in the risk of age-related hearing loss (presbycusis).

“Dietary intervention with omega-3 polyunsaturated fatty acids could prevent or delay the development of age-related hearing loss,” wrote the researches, led by Paul Mitchell.



Hearing loss is the most common sensory disorder in the United States, affecting more than 36 million people.

Beyond omega-3

Other micronutrients have been linked to reducing the risk of age-related hearing loss. In 2007 scientists from Wageningen University reported that folic acid supplements delayed age-related hearing loss in the low frequency region in a study of 728 men and women between the ages of 50 and 70 (Annals of Internal Medicine, Vol. 146, pp. 1-9).

Another study, published earlier this year indicated a role for beta carotene and vitamins C and E, and the mineral magnesium in preventing prevent both temporary and permanent hearing loss in guinea pigs and mice. The animal study was presented at the Association for Research in Otolaryngology's annual conference in Baltimore in February 2009.

Fish: Food for hearing

Mitchell and his co-workers analysed data from 2,956 participants of the Blue Mountains Hearing Study. Dietary intakes of fish, and the omega-3s they contain, using food-frequency questionnaires.

Results showed an inverse association between total and long-chain omega-3 intakes and hearing loss, while increasing fish intakes also indicated a reduction in the risk of presbycusis, said the researchers.

Correlation is not causation, however, and significant further research is needed, including human intervention trials.

Listening to the market

Omega-3 is one of the stars of the nutrition industry, with the ingredients market valued at a whopping $1.6 billion by Frost & Sullivan. The fatty acids, most notably EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), have been linked to a wide-range of health benefits, including reduced risk of cardiovascular disease (CVD) and certain cancers, good development of a baby during pregnancy, joint health, and improved behaviour and mood.
Increased intakes of omega-3 fatty acids, and the fish that provide them, may reduce the risk of age-related hearing loss, says a new study from the University of Sydney.

At least two servings of fish per week was associated with a 42 per cent reduction in the risk of hearing loss in over 50 year-olds, compared with people who average less than one serving per week, according to findings published in the American Journal of Clinical Nutrition.

Similar reductions were observed with intakes of long-chain omega-3 fatty acids, with increasing intakes associated with 14 per cent reductions in the risk of age-related hearing loss (presbycusis).

“Dietary intervention with omega-3 polyunsaturated fatty acids could prevent or delay the development of age-related hearing loss,” wrote the researches, led by Paul Mitchell.



Hearing loss is the most common sensory disorder in the United States, affecting more than 36 million people.

Beyond omega-3

Other micronutrients have been linked to reducing the risk of age-related hearing loss. In 2007 scientists from Wageningen University reported that folic acid supplements delayed age-related hearing loss in the low frequency region in a study of 728 men and women between the ages of 50 and 70 (Annals of Internal Medicine, Vol. 146, pp. 1-9).

Another study, published earlier this year indicated a role for beta carotene and vitamins C and E, and the mineral magnesium in preventing prevent both temporary and permanent hearing loss in guinea pigs and mice. The animal study was presented at the Association for Research in Otolaryngology's annual conference in Baltimore in February 2009.

Fish: Food for hearing

Mitchell and his co-workers analysed data from 2,956 participants of the Blue Mountains Hearing Study. Dietary intakes of fish, and the omega-3s they contain, using food-frequency questionnaires.

Results showed an inverse association between total and long-chain omega-3 intakes and hearing loss, while increasing fish intakes also indicated a reduction in the risk of presbycusis, said the researchers.

Correlation is not causation, however, and significant further research is needed, including human intervention trials.

Listening to the market

Omega-3 is one of the stars of the nutrition industry, with the ingredients market valued at a whopping $1.6 billion by Frost & Sullivan. The fatty acids, most notably EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), have been linked to a wide-range of health benefits, including reduced risk of cardiovascular disease (CVD) and certain cancers, good development of a baby during pregnancy, joint health, and improved behaviour and mood.
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Thursday, June 10, 2010

Antimicrobial Resistance in Cats

Shaheen BW, Boothe DM, Oyarzabal OA et al: Antimicrobial resistance profiles and clonal relatedness of canine and feline Escherichia coli pathogens expressing multidrug resistance in the United States, J Vet Intern Med 24:323, 2010.

Antibiotic resistance has been documented in E. coli isolates from human, animal and environmental resources. An emerging health concern is the multidrug resistant (MDR) strains of Eshcerichia coli. There have been a number of studies that demonstrate an increase in MDR E. coli associated with infections in dogs and cats throughout the United States and Europe. In this study, 376 isolates of E. coli were collected from dogs and cats from the South, West, Northeast, and Midwest regions of the United States from May to September 2005. 51% of the isolates expressed resistance to at least one drug and 44% of those isolates were single drug resistant (SDR), most commonly amoxicillin. The MDR isolates (56%) were resistant to amoxicillin, amoxicillin-clavulanate, and enrofloxacin; 18% were resistant to all drugs tested. The majority of the E.coli isolates were genetically and phenotypically distinct from one another. The frequency of MDR did not differ regionally in the United States. The study underscores the need to understand that MDR isolates are not only resistant to many drugs, but the level of resistance to those drugs is very high and thus might not be overcome by increasing doses, nor combination antimicrobial therapy. Therefore, implementation of a robust surveillance program for antimicrobial resistance is recommended. [VT]

Related articles:
Murphy C, Reid-Smith R, Prescott J et al: Occurrence of antimicrobial resistant bacteria in healthy dogs and cats presented to private veterinary hospitals in southern Ontario: a preliminary study, Can Vet J 50:1047, 2009.

More on cat health: Winn Feline Foundation Library
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Shaheen BW, Boothe DM, Oyarzabal OA et al: Antimicrobial resistance profiles and clonal relatedness of canine and feline Escherichia coli pathogens expressing multidrug resistance in the United States, J Vet Intern Med 24:323, 2010.

Antibiotic resistance has been documented in E. coli isolates from human, animal and environmental resources. An emerging health concern is the multidrug resistant (MDR) strains of Eshcerichia coli. There have been a number of studies that demonstrate an increase in MDR E. coli associated with infections in dogs and cats throughout the United States and Europe. In this study, 376 isolates of E. coli were collected from dogs and cats from the South, West, Northeast, and Midwest regions of the United States from May to September 2005. 51% of the isolates expressed resistance to at least one drug and 44% of those isolates were single drug resistant (SDR), most commonly amoxicillin. The MDR isolates (56%) were resistant to amoxicillin, amoxicillin-clavulanate, and enrofloxacin; 18% were resistant to all drugs tested. The majority of the E.coli isolates were genetically and phenotypically distinct from one another. The frequency of MDR did not differ regionally in the United States. The study underscores the need to understand that MDR isolates are not only resistant to many drugs, but the level of resistance to those drugs is very high and thus might not be overcome by increasing doses, nor combination antimicrobial therapy. Therefore, implementation of a robust surveillance program for antimicrobial resistance is recommended. [VT]

Related articles:
Murphy C, Reid-Smith R, Prescott J et al: Occurrence of antimicrobial resistant bacteria in healthy dogs and cats presented to private veterinary hospitals in southern Ontario: a preliminary study, Can Vet J 50:1047, 2009.

More on cat health: Winn Feline Foundation Library
Join us on Facebook
Follow us on Twitter
Read More


Monday, June 7, 2010

Ginger supplements may reduce pain after exercise: Study

Ginger may reduce the pain associated with muscle injury after exercising, offering amateur and professional athletes a natural pain reliever, suggests new data.

Both raw and heat-treated ginger reduced the pain associated with muscle injury by about 24 per cent, compared with placebo, according to findings published in The Journal of Pain.

“The primary novel finding was that supplementation with both raw and heat-treated ginger attenuated muscle pain intensity 24 hours after eccentric exercise,” wrote the researchers, led by Chris Black, PhD, from Georgia College and State University.

“Consumption of raw ginger resulted in a 25 per cent reduction while heat-treated ginger resulted in a 23 per cent reduction in muscle-pain intensity 24 hours post-exercise,” they added.

The rhizome of the ginger plant (Zingiber officinale) is a rich source of antioxidants, including gingerols, shogaols, zingerones and other ketone derivatives. According to Black and his co-workers from the University of Georgie, ginger’s pain reducing effects are biologically plausible with both in vitro and in vivo animal studies showing an effect of gingerols, shogaols, and zingerones on inflammatory compounds.

“[This suggests] ginger may have anti-inflammatory and analgesic properties akin to nonsteroidal anti-inflammatory drugs,” stated the researchers.

In order to test this hypothesis, the researchers recruited 74 volunteers and randomly assigned them to consume two grams of raw or heat-treated ginger supplements for 11 days in a double-blind, placebo-controlled, randomized design.

The subjects then performed 18 extensions of the elbow flexors with a heavy weight to induce moderate muscle injury to the arm. Arm function, inflammation, and pain were assessed prior to and for three days after exercise.
Ginger may reduce the pain associated with muscle injury after exercising, offering amateur and professional athletes a natural pain reliever, suggests new data.

Both raw and heat-treated ginger reduced the pain associated with muscle injury by about 24 per cent, compared with placebo, according to findings published in The Journal of Pain.

“The primary novel finding was that supplementation with both raw and heat-treated ginger attenuated muscle pain intensity 24 hours after eccentric exercise,” wrote the researchers, led by Chris Black, PhD, from Georgia College and State University.

“Consumption of raw ginger resulted in a 25 per cent reduction while heat-treated ginger resulted in a 23 per cent reduction in muscle-pain intensity 24 hours post-exercise,” they added.

The rhizome of the ginger plant (Zingiber officinale) is a rich source of antioxidants, including gingerols, shogaols, zingerones and other ketone derivatives. According to Black and his co-workers from the University of Georgie, ginger’s pain reducing effects are biologically plausible with both in vitro and in vivo animal studies showing an effect of gingerols, shogaols, and zingerones on inflammatory compounds.

“[This suggests] ginger may have anti-inflammatory and analgesic properties akin to nonsteroidal anti-inflammatory drugs,” stated the researchers.

In order to test this hypothesis, the researchers recruited 74 volunteers and randomly assigned them to consume two grams of raw or heat-treated ginger supplements for 11 days in a double-blind, placebo-controlled, randomized design.

The subjects then performed 18 extensions of the elbow flexors with a heavy weight to induce moderate muscle injury to the arm. Arm function, inflammation, and pain were assessed prior to and for three days after exercise.
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Burger diet linked to higher childhood asthma risk

Researchers from Germany, Spain and Britain who studied data on 50,000 children across the world found the link between burgers and asthma was strongest in rich nations where diets with high levels of junk food are more common.

A meat-heavy diet itself has no bearing on the prevalence of asthma, according to the scientists who conducted the study. Yet, frequent burger eating could be a signal for other lifestyle factors which raise asthma risk.

"This is a sign that the link is not strongly related to the food itself, but that burgers are a proxy for other lifestyle and environmental factors like obesity and lack of exercise," said Gabriele Nagel of the Institute of Epidemiology at Ulm University, Germany, who led the study.

She added, however, that there were "biologically plausible" links for the positive effects of a healthier diet, which could be down to the antioxidants found in fruit and vegetables, and the omega 3 polyunsaturated fatty acids in fish, which have anti-inflammatory properties.

"Fruit and vegetables contain antioxidants and other biologically active factors which may contribute to the favorable effect...in asthma," Nagel said.

In particular, she added, foods rich in vitamin C have been linked to better lung function and fewer asthma symptoms.

Around 1.1 million children currently receive treatment for asthma in Britain, while in the United States it is the most common chronic childhood disease, with around 10 million children diagnosed with it.

Nagel's team looked at data on 50,000 children aged between 8 and 12 years from 20 rich and poor countries around the world.

While diet was not linked to children being more prone to allergies in general, it did seem to influence the prevalence of asthma and wheezing, they found.

"Overall, more frequent consumption of fruit, vegetables and fish was associated with a lower lifetime prevalence of asthma, whereas high burger consumption was associated with higher lifetime asthma prevalence," they wrote in the study, which was published in Thorax, a British Medical Journal title.

This study adds to an existing body of evidence showing the health benefits of a so-called Mediterranean diet -- rich in fruit, vegetables, whole grains, nuts and fish -- including reduced risks of heart disease, diabetes, cancer and depression.
Researchers from Germany, Spain and Britain who studied data on 50,000 children across the world found the link between burgers and asthma was strongest in rich nations where diets with high levels of junk food are more common.

A meat-heavy diet itself has no bearing on the prevalence of asthma, according to the scientists who conducted the study. Yet, frequent burger eating could be a signal for other lifestyle factors which raise asthma risk.

"This is a sign that the link is not strongly related to the food itself, but that burgers are a proxy for other lifestyle and environmental factors like obesity and lack of exercise," said Gabriele Nagel of the Institute of Epidemiology at Ulm University, Germany, who led the study.

She added, however, that there were "biologically plausible" links for the positive effects of a healthier diet, which could be down to the antioxidants found in fruit and vegetables, and the omega 3 polyunsaturated fatty acids in fish, which have anti-inflammatory properties.

"Fruit and vegetables contain antioxidants and other biologically active factors which may contribute to the favorable effect...in asthma," Nagel said.

In particular, she added, foods rich in vitamin C have been linked to better lung function and fewer asthma symptoms.

Around 1.1 million children currently receive treatment for asthma in Britain, while in the United States it is the most common chronic childhood disease, with around 10 million children diagnosed with it.

Nagel's team looked at data on 50,000 children aged between 8 and 12 years from 20 rich and poor countries around the world.

While diet was not linked to children being more prone to allergies in general, it did seem to influence the prevalence of asthma and wheezing, they found.

"Overall, more frequent consumption of fruit, vegetables and fish was associated with a lower lifetime prevalence of asthma, whereas high burger consumption was associated with higher lifetime asthma prevalence," they wrote in the study, which was published in Thorax, a British Medical Journal title.

This study adds to an existing body of evidence showing the health benefits of a so-called Mediterranean diet -- rich in fruit, vegetables, whole grains, nuts and fish -- including reduced risks of heart disease, diabetes, cancer and depression.
Read More


Chili Peppers Might Fight Fat

The stuff that makes chili peppers hot, capsaicin, may cause weight loss and fight fat buildup by triggering certain beneficial protein changes in the body.

A new study, done on rats, might help lead to treatments for human obesity, the researchers said.

Jong Won Yun at Daegu University in Korea and colleagues point out that obesity is a major public health threat worldwide, linked to diabetes, high blood pressure, heart disease, and other health problems. Laboratory studies have hinted that capsaicin may help fight obesity by decreasing calorie intake, shrinking fat tissue, and lowering fat levels in the blood. Nobody, however, knows exactly how capsaicin might trigger such beneficial effects.

In an effort to find out, the scientists fed high-fat diets with or without capsaicin to lab rats used to study obesity. The capsaicin-treated rats lost 8 percent of their body weight and showed changes in levels of at least 20 key proteins found in fat. The altered proteins work to break down fats.

"These changes provide valuable new molecular insights into the mechanism of the antiobesity effects of capsaicin," the scientists say.

The findings are detailed in the American Chemical Society's journal of Proteome Research.
The stuff that makes chili peppers hot, capsaicin, may cause weight loss and fight fat buildup by triggering certain beneficial protein changes in the body.

A new study, done on rats, might help lead to treatments for human obesity, the researchers said.

Jong Won Yun at Daegu University in Korea and colleagues point out that obesity is a major public health threat worldwide, linked to diabetes, high blood pressure, heart disease, and other health problems. Laboratory studies have hinted that capsaicin may help fight obesity by decreasing calorie intake, shrinking fat tissue, and lowering fat levels in the blood. Nobody, however, knows exactly how capsaicin might trigger such beneficial effects.

In an effort to find out, the scientists fed high-fat diets with or without capsaicin to lab rats used to study obesity. The capsaicin-treated rats lost 8 percent of their body weight and showed changes in levels of at least 20 key proteins found in fat. The altered proteins work to break down fats.

"These changes provide valuable new molecular insights into the mechanism of the antiobesity effects of capsaicin," the scientists say.

The findings are detailed in the American Chemical Society's journal of Proteome Research.
Read More