Showing posts with label upper respiratory tract disease. Show all posts

Monday, November 19, 2012

Efficacy of intranasal vaccination in cats

Bradley A, Kinyon J, Frana T, Bolte D, Hyatt DR and Lappin MR. Efficacy of intranasal administration of a modified live feline herpesvirus 1 and feline calicivirus vaccine against disease caused by Bordetella bronchiseptica after experimental challenge. J Vet Intern Med. 2012; 26: 1121-5.

Upper respiratory tract infections (URTI) are common problems affecting cats in shelters, boarding facilities, breeding catteries, and pet homes. The most common causes of URTI include feline herpesvirus 1 (FHV), feline calicivirus (FCV), Bordetella bronchiseptica, Chlamydophila felis, Mycoplasma spp, and some bacteria. However, vaccines are only available for FHV, FCV, B. bronchiseptica, and C. felis. No single product is available to provide protection against all 4 agents in one vaccine.

Most feline vaccines are formulated for parenteral use, but there are 2 products on the market in the United States designed for intranasal administration. Intranasal administration of vaccines stimulates a nonspecific immune response in addition to the specific immune response against the agent in the vaccine. These investigators examined the effect of intranasal vaccination against FHV and FCV on disease caused by B. bronchiseptica. Two groups of 10 cats each were either inoculated intranasally with the vaccine or left unvaccinated. They were then exposed to B. bronchiseptica seven days later. Vaccinated cats were found to be less likely to be clinically ill than unvaccinated cats. Thus, intranasal vaccination with FHV and FCV decreased disease caused by a different pathogen due to its stimulation of nonspecific immunity. [MK]

See also: Egberink H, Addie D, Belak S, et al. Bordetella bronchiseptica infection in cats ABCD guidelines on prevention and management. J Feline Med Surg. 2009; 11: 610-4.
Free, full text article updated 2012

Related blog articles:
Treatment of feline upper respiratory tract disease (August 2012)
Upper respiratory tract disease in shelters (November 2009)
Understanding chronic respiratory disease in cats (August 2009)

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Treatment of feline upper respiratory tract disease

Litster AL, Wu CC and Constable PD. Comparison of the efficacy of amoxicillin-clavulanic acid, cefovecin, and doxycycline in the treatment of upper respiratory tract disease in cats housed in an animal shelter. J Am Vet Med Assoc. 2012; 241: 218-26.

Upper respiratory tract disease (URTD) is one of the most common causes of disease in cats and also among the most common causes of euthanasia in animal shelters. The objective of this study was to compare the efficacy of amoxicillin-clavulanic acid, cefovecin, and doxycycline in shelter-housed cats with clinical signs of URTD. Cats were randomly assigned to 3 treatment groups of 16 cats each. Conjunctival and nasal swab specimens were obtained for culture and susceptibility testing. Different parameters - oculonasal discharge, sneezing, coughing, dyspnea, demeanor, and food intake - were scored twice daily for 14 days.

The most common bacterial isolates found were Mycoplasma spp. (n=22) and Bordetella bronchiseptica (n=9). The cats treated with amoxicillin-clavulanic acid or doxycycline had significantly increased body weight by the end of the study. The cats receiving doxycycline had significantly lower oculonasal discharge scores than the ones treated with amoxicillin-clavulanic acid or cefovecin. Those treated with amoxicillin-clavulanic acid or doxycycline had significantly lower sneezing scores than the cats receiving cefovecin. All of the Bordetella isolates in this study were resistant to cefovecin in vitro. Oral administration of amoxicillin-clavulanic acid or doxycycline appeared to be more effective than a single subcutaneous injection of cefovecin in treating shelter cats with signs of URTD. [VT]

See also: Tanaka A, Wagner DC, Kass PH and Hurley KF. Associations among weight loss, stress, and upper respiratory tract infection in shelter cats. J Am Vet Med Assoc. 2012; 240: 570-6.

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Adoption of Shelter Kittens

Litster A, Allen J, Mohamed A et al: Risk factors for delays between intake and veterinary approval for adoption on medical grounds in shelter puppies and kittens, Preventive Veterinary Medicine 101:107, 2011.

In shelter and rescue situations, it is very important to identify highly adoptable animals whose adoptions are unlikely to be delayed for medical reasons. The objective of this study was to identify risk factors for delays on medical grounds from intake to approval for adoption in shelter puppies and kittens. Records from over 300 puppies and 300 kittens in a large metropolitan shelter were examined. Not surprisingly, kittens exhibiting respiratory or gastrointestinal problems upon intake were more likely to have delayed adoption. Older kittens were less likely than young kittens to experience this delay. Stray kittens, as opposed to owner-relinquished kittens, or kittens transferred from another shelter, were more likely to experience delays for adoption. Prompt antimicrobial therapy for infectious diseases was associated with a significant decrease in the delay for adoption. Additional studies at other shelters will be useful, but this study indicates that rapid treatment of kittens and puppies with mild infections is very important to decrease their time in a shelter. [MK]

Related articles: Bannasch M, Foley J: Epidemiologic evaluation of multiple respiratory pathogens in cats in animal shelters, J Feline Med Surg 7:109, 2005.

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Lysine for Feline Upper Respiratory Tract Disease

Drazenovich, T. L., A. J. Fascetti, et al. (2009). "Effects of dietary lysine supplementation on upper respiratory and ocular disease and detection of infectious organisms in cats within an animal shelter." Am J Vet Res 70(11): 1391-400.

Feline herpesvirus (FHV) is a common cause of respiratory infections in cats housed in shelter situations. Cats latently infected with feline herpesvirus are important sources of the virus for cats that are susceptible to infection. Medications that interfere with latency establishment or reactivation of latent infections would be extremely useful, especially in rescue facilities, where animals are often highly stressed, and have variable vaccination history and immune status. Lysine has shown promise in mediating antiviral effects in cats. These researchers investigated the usefulness of dietary supplementation with lysine for cats in shelters to decrease incidence of infection and detection of FHV shedding. Using 261 adult cats, basal diets (control group) and diets supplemented with lysine (treated group) were fed for four weeks. Unexpectedly, they found that treated cats were actually more likely to manifest severe disease than untreated controls at certain time points in the study (week 4). In addition, FHV was detected more commonly in treated cats (found in week 2 only). A confounding factor was that cats in both groups were also allowed access to commercial diets when hospitalized for illness in addition to the control and test diets. The researchers concluded that continuous dietary supplementation with lysine did not successfully control respiratory disease in a shelter situation, and is not an optimal use of funds in rescue facilities. Bolus treatment of cats with lysine may provide better plasma lysine levels than continuous dietary supplementation, and may provide more beneficial effects.
>> PubMed Abstract

Related articles:
Maggs, D. J., J. E. Sykes, et al. (2007). "Effects of dietary lysine supplementation in cats with enzootic upper respiratory disease." J Feline Med Surg 9(2): 97-108.
>> PubMed Abstract

Rees, T. M. and J. L. Lubinski (2008). "Oral supplementation with L-lysine did not prevent upper respiratory infection in a shelter population of cats." J Feline Med Surg 10(5): 510-3.
>> PubMed Abstract

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Upper Respiratory Tract Disease in Shelters

Dinnage, J.D., J.M. Scarlett, and J.R. Richards, Descriptive epidemiology of feline upper respiratory tract disease in an animal shelter. J Feline Med Surg, 2009. 11(10): p. 816-25.

Upper respiratory tract disease (URTD) is a common disease in cats and can spread quickly among cats residing in animal shelters. These infections cause suffering, consume vital personnel and financial resources, and limit adoptions. In a large urban shelter in the northeast United States, 531 kittens, 701 litters, and 2,203 adult cats were observed during their stays on a daily basis over a period of 50 weeks for signs of URTD. The median lengths of stay for adult cats and kittens were 5 and 4 days, respectively. Approximately 1/3 of the cats exhibited signs of infectious respiratory disease. Regardless of age group, the probability of developing URTD rose steadily with increasing time spent in the shelter. The probability of exhibiting signs remained low until day 6 and then rose steadily to where by day 14, the cumulative probabilities had risen to 84% (litters), 86% (individual kittens), and 80% (adult cats). In different categories, adult cats over 11 years of age had a significantly higher risk of URTD than younger cats. Neutered males cats had higher rates of URTD than spayed females, and purebred cats were at higher risk than ones of mixed breeding. Strays were more likely to have URTD than owner-surrendered cats. The study documented the strong association between the length of the residence in a shelter and the risk of developing URTD. The results suggest shelters should focus efforts and programs at minimizing the length of time cats spend in a shelter. [VT]
>> PubMed Abstract

Related articles:
Zicola, A., et al., Feline herpesvirus 1 and feline calicivirus infections in a heterogeneous cat population of a rescue shelter. J Feline Med Surg, 2009.
>> PubMed Abstract

Edwards, D.S., et al., Risk factors for time to diagnosis of feline upper respiratory tract disease in UK animal adoption shelters. Prev Vet Med, 2008. 87(3-4): p. 327-39.
>> PubMed Abstract

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Understanding Chronic Respiratory Disease in Cats

Johnson, L.R. and P.H. Kass, Effect of sample collection methodology on nasal culture results in cats. Journal of Feline Medicine & Surgery, 2009. 11(8): p. 645-649.

Feline chronic rhinosinusitis (CRS) is a common disease in cats with an unknown etiology. A number of studies have indicated that most cases of upper respiratory disease in the cat are complicated by secondary bacterial infections. Empiric antibiotic therapy is frequently employed to treat feline CRS. This study evaluated the effect of sampling method on culture results in 44 cats. The results indicated that aerobic and anaerobic cultures were positive significantly more often from nasal flush samples than from tissue biopsy samples. Culture results did not differ for Mycoplasma species between flush and biopsy samples though there was discordancy in 8 of 44 sample pairs for Mycoplasma species. This indicates that a failure to culture Mycoplasma species from a nasal flush might not be a true reflection of the absence of Mycoplasma species in the nasal cavity since a tissue sample may be required for isolation of the organism. Nasal flush is the preferred technique though for determining presence in feline nasal disease of potentially pathogenic bacterial organisms. [VT]
>> PubMed Abstract

Related articles:
Berryessa, N.A., et al., Microbial culture of blood samples and serologic testing for bartonellosis in cats with chronic rhinosinusitis. Journal of the American Veterinary Medical Association, 2008. 233(7): p. 1084-1089.
>> PubMed Abstract

Ruch-Gallie, R.A., et al., Efficacy of amoxycillin and azithromycin for the empirical treatment of shelter cats with suspected bacterial upper respiratory infections. Journal of Feline Medicine & Surgery, 2008. 10(6): p. 542-550.
>> PubMed Abstract

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Herpesvirus Infections in Cats

Westermeyer, H. D., S. M. Thomasy, et al. (2009). "Assessment of viremia associated with experimental primary feline herpesvirus infection or presumed herpetic recrudescence in cats." American Journal of Veterinary Research 70(1): 99-104.

Feline herpesvirus-1 is associated with respiratory disease, often in kittens. Most infected cats remain latently infected for life; these latent infections may reactivate during times of stress. While herpesviruses in other species commonly spread to other tissues in infected animals via the bloodstream, this appears to be infrequent in cats. These researchers investigated the occurrence of virus in the blood of infected cats during acute infection, as well as during reactivation of latent infections. Following infection of six cats with FHV-1, virus was detected in the blood for up to two weeks post-infection. However, virus was not detected in the blood of 34 shelter cats, 25 of whom had evidence of FHV-associated disease and tested positive for the virus on conjunctival samples, using either virus isolation or polymerase chain reaction (PCR) testing. The authors conclude there may be a brief period of viremia in cats following acute infection, but none associated with reactivation of latent infection. [MK]
>> PubMed Abstract

Related articles:
Maggs, D., M. Lappin, et al. (1999). "Evaluation of serologic and viral detection methods for diagnosing feline herpesvirus-1 infection in cats with acute respiratory tract or chronic ocular disease." J Amer Vet Med Assoc 214(4): 502.
>> PubMed Abstract

Bannasch, M. and J. Foley (2005). "Epidemiologic evaluation of multiple respiratory pathogens in cats in animal shelters." J Fel Med Surg 7(2): 109-119.
>> PubMed Abstract

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Chronic sinusitis and Bartonella in Cats

Berryessa NA, Johnson LR, Kasten RW, Chomel BB. Microbial culture of blood samples and serologic testing for bartonellosis in cats with chronic rhinosinusitis. Journal of the American Veterinary Medical Association. 2008;233(7):1084-1089.

Chronic rhinosinutitis (CRS) is a frequent and frustrating medical disorder of cats. A common finding is excessive accumulation of nasal mucus along with sneezing, nasal discharge, and turbinate bone damage. The underlying cause for this disease is most likely multifactorial and due to a mix of a viral infection, secondary bacterial infection, and a poorly developed immune response. Treatment has primarily been directed at the result of the disease instead of potential causes. Bartonella are blood borne organisms most likely transmitted to cats through exposure to flea feces. Bartonella have been implicated in nasal inflammation in small animals and often private clinicians will test for the organism along with treating with azithromycin on the assumption that Bartonella is present. This study consisted of 4 groups of cats. The first group (19 cats) was composed of cats with CRS whose diagnosis was based on having a mucopurulent discharge longer than 3 months. The remaining 3 control groups were cats with other nasal diseases (Group 2: 10 cats), cats with systemic disease with no nasal disease (Group 3: 15 cats), and healthy cats (Group 4: 15 cats). All cats in the study had serologic testing for Bartonella henselae and Bartonella clarridgeiae and microbial cultures of blood samples performed. In those cats where nasal disease was evaluated, a biopsy sample was taken for histologic examination and another biopsy sample saved for PCR assay to detect Bartonella. The results of the study showed no significant differences in seropositivity or culture results in cats with CRS compared to the results of the 3 control groups. A positive serologic test for Bartonella would most likely indicate exposure and not presence of infection from the organism. In addition, the PCR assays of the nasal tissue samples were negative indicating that Bartonella organisms do not play an important role in the pathogenesis of CRS as demonstrated in these cats. One limitation of the study was the small number of cats enrolled. The authors do recommend a continued need to look for an association between Bartonella and other chronic inflammatory diseases in cats. [VT]
>> PubMed Abstract

Related articles:
Johnson L, Foley J, DeCock H, al e. Assessment of infectious organisms associated with severe chronic rhinosinusitis in cats. J Amer Vet Med Assoc. 2005;227(4):579-585.
>> PubMed Abstract

Quimby JM, Elston T, Hawley J, Brewer M, Miller A, Lappin MR. Evaluation of the association of Bartonella species, feline herpesvirus 1, feline calicivirus, feline leukemia virus and feline immunodeficiency virus with chronic feline gingivostomatitis. J Feline Med Surg. Feb 2008;10(1):66-72.
>> PubMed Abstract

More on cat health: Winn Feline Foundation Library

Pradofloxacin For Feline Upper Respiratory Tract Disease

Hartmann, A. D., C. R. Helps, et al. (2008). "Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections." J Vet Intern Med 22(1): 44-52.

Two of the pathogens implicated in feline upper respiratory tract disease (URTD) are Chlamydophila felis and Mycoplasma. Typical treatment for these pathogens has been doxycycline or enrofloxacin. Both drugs are associated with adverse effects. This study investigated the efficacy of a novel fluoroquinolone, pradofloxacin, for treatment of these pathogens. In this placebo-controlled, double-blind clinical trial, 39 cats with clinical signs of URTD were divided into 2 treatment groups. One group was treated with pradofloxacin and the other group was treated with doxycycline; both groups were treated for 42 days. Clinical scores were evaluated as response to treatment. The presence of C. felis and Mycoplasma was determined by PCR analysis of conjunctival swabs. Before treatment, C. felis was detected in 23 cats, and Mycoplasma was detected in 20 cats. Both groups of cats responded to treatment with a marked improvement in clinical signs within 1 week. Complete elimination of Mycoplasma was achieved in both groups of cats. However, while all cats receiving doxycycline eliminated C. felis, 4 cats treated with pradofloxacin remained PCR-positive.
>> PubMed abstract

Related articles:
Hartmann, A., R. Krebber, et al. (2008). "Pharmacokinetics of pradofloxacin and doxycycline in serum, saliva, and tear fluid of cats after oral administration." J Vet Pharmacol Ther 31(2): 87-94.
>> PubMed abstract

Litster, A., S. Moss, et al. (2007). "Clinical efficacy and palatability of pradofloxacin 2.5% oral suspension for the treatment of bacterial lower urinary tract infections in cats." J Vet Intern Med 21(5): 990-5.
>> PubMed abstract

More on cat health: Winn Feline Foundation Library

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Monday, November 19, 2012

Efficacy of intranasal vaccination in cats

Friday, August 3, 2012

Treatment of feline upper respiratory tract disease

Wednesday, November 16, 2011

Adoption of Shelter Kittens

Monday, November 30, 2009

Lysine for Feline Upper Respiratory Tract Disease

Thursday, November 12, 2009

Upper Respiratory Tract Disease in Shelters

Monday, August 31, 2009

Understanding Chronic Respiratory Disease in Cats

Wednesday, June 10, 2009

Herpesvirus Infections in Cats

Thursday, March 5, 2009

Chronic sinusitis and Bartonella in Cats

Thursday, March 20, 2008

Pradofloxacin For Feline Upper Respiratory Tract Disease