Pradofloxacin for Feline Infectious Anemia

Dowers, K. L., S. Tasker, et al. (2009). "Use of pradofloxacin to treat experimentally induced Mycoplasma hemofelis infection in cats." Am J Vet Res 70(1): 105-11.

Mycoplasma hemofelis, formerly known as Hemobartonella felis, is the causative agent of feline infectious anemia. The bacterium is spread through flea bites and causes hemolytic anemia that may result in the death of infected cats. It is believed that most infected cats do not clear the organisms even with appropriate antimicrobial treatment, which most commonly is doxycycline. Pradofloxacin is a new fluoroquinolone antibiotic for veterinary use that appears to have increased effectiveness against many bacteria. In this study, treatment of cats infected with M. hemofelis with doxycycline was compared to low and high doses of pradofloxacin. All treatment regimens were equally effective in improving the clinical condition and blood parameters of infected cats. When assessed by molecular detection for clearance of the organism, both low and high dose pradofloxacin were effective, while none of the doxycycline-treated animals completely cleared detectable organisms. The authors concluded that pradofloxacin not only had anti-M. hemofelis effects, it may be more effective at long term M. hemofelis organism clearance than doxycycline.
>> PubMed Abstract

Related articles:
Willi, B., F. S. Boretti, et al. (2007). "From Haemobartonella to hemoplasma: Molecular methods provide new insights." Vet Microbiol 125(3-4): 197-209.
>> PubMed Abstract

Ishak, A. M., K. L. Dowers, et al. (2008). "Marbofloxacin for the treatment of experimentally induced Mycoplasma haemofelis infection in cats." J Vet Intern Med 22(2): 288-92.
>> PubMed Abstract

More on cat health: Winn Feline Foundation Library

Dowers, K. L., S. Tasker, et al. (2009). "Use of pradofloxacin to treat experimentally induced Mycoplasma hemofelis infection in cats." Am J Vet Res 70(1): 105-11.

Mycoplasma hemofelis, formerly known as Hemobartonella felis, is the causative agent of feline infectious anemia. The bacterium is spread through flea bites and causes hemolytic anemia that may result in the death of infected cats. It is believed that most infected cats do not clear the organisms even with appropriate antimicrobial treatment, which most commonly is doxycycline. Pradofloxacin is a new fluoroquinolone antibiotic for veterinary use that appears to have increased effectiveness against many bacteria. In this study, treatment of cats infected with M. hemofelis with doxycycline was compared to low and high doses of pradofloxacin. All treatment regimens were equally effective in improving the clinical condition and blood parameters of infected cats. When assessed by molecular detection for clearance of the organism, both low and high dose pradofloxacin were effective, while none of the doxycycline-treated animals completely cleared detectable organisms. The authors concluded that pradofloxacin not only had anti-M. hemofelis effects, it may be more effective at long term M. hemofelis organism clearance than doxycycline.
>> PubMed Abstract

Related articles:
Willi, B., F. S. Boretti, et al. (2007). "From Haemobartonella to hemoplasma: Molecular methods provide new insights." Vet Microbiol 125(3-4): 197-209.
>> PubMed Abstract

Ishak, A. M., K. L. Dowers, et al. (2008). "Marbofloxacin for the treatment of experimentally induced Mycoplasma haemofelis infection in cats." J Vet Intern Med 22(2): 288-92.
>> PubMed Abstract

More on cat health: Winn Feline Foundation Library

Read More

Pradofloxacin For Feline Upper Respiratory Tract Disease

Hartmann, A. D., C. R. Helps, et al. (2008). "Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections." J Vet Intern Med 22(1): 44-52.

Two of the pathogens implicated in feline upper respiratory tract disease (URTD) are Chlamydophila felis and Mycoplasma. Typical treatment for these pathogens has been doxycycline or enrofloxacin. Both drugs are associated with adverse effects. This study investigated the efficacy of a novel fluoroquinolone, pradofloxacin, for treatment of these pathogens. In this placebo-controlled, double-blind clinical trial, 39 cats with clinical signs of URTD were divided into 2 treatment groups. One group was treated with pradofloxacin and the other group was treated with doxycycline; both groups were treated for 42 days. Clinical scores were evaluated as response to treatment. The presence of C. felis and Mycoplasma was determined by PCR analysis of conjunctival swabs. Before treatment, C. felis was detected in 23 cats, and Mycoplasma was detected in 20 cats. Both groups of cats responded to treatment with a marked improvement in clinical signs within 1 week. Complete elimination of Mycoplasma was achieved in both groups of cats. However, while all cats receiving doxycycline eliminated C. felis, 4 cats treated with pradofloxacin remained PCR-positive.
>> PubMed abstract

Related articles:
Hartmann, A., R. Krebber, et al. (2008). "Pharmacokinetics of pradofloxacin and doxycycline in serum, saliva, and tear fluid of cats after oral administration." J Vet Pharmacol Ther 31(2): 87-94.
>> PubMed abstract

Litster, A., S. Moss, et al. (2007). "Clinical efficacy and palatability of pradofloxacin 2.5% oral suspension for the treatment of bacterial lower urinary tract infections in cats." J Vet Intern Med 21(5): 990-5.
>> PubMed abstract

More on cat health: Winn Feline Foundation Library

Hartmann, A. D., C. R. Helps, et al. (2008). "Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections." J Vet Intern Med 22(1): 44-52.

Two of the pathogens implicated in feline upper respiratory tract disease (URTD) are Chlamydophila felis and Mycoplasma. Typical treatment for these pathogens has been doxycycline or enrofloxacin. Both drugs are associated with adverse effects. This study investigated the efficacy of a novel fluoroquinolone, pradofloxacin, for treatment of these pathogens. In this placebo-controlled, double-blind clinical trial, 39 cats with clinical signs of URTD were divided into 2 treatment groups. One group was treated with pradofloxacin and the other group was treated with doxycycline; both groups were treated for 42 days. Clinical scores were evaluated as response to treatment. The presence of C. felis and Mycoplasma was determined by PCR analysis of conjunctival swabs. Before treatment, C. felis was detected in 23 cats, and Mycoplasma was detected in 20 cats. Both groups of cats responded to treatment with a marked improvement in clinical signs within 1 week. Complete elimination of Mycoplasma was achieved in both groups of cats. However, while all cats receiving doxycycline eliminated C. felis, 4 cats treated with pradofloxacin remained PCR-positive.
>> PubMed abstract

Related articles:
Hartmann, A., R. Krebber, et al. (2008). "Pharmacokinetics of pradofloxacin and doxycycline in serum, saliva, and tear fluid of cats after oral administration." J Vet Pharmacol Ther 31(2): 87-94.
>> PubMed abstract

Litster, A., S. Moss, et al. (2007). "Clinical efficacy and palatability of pradofloxacin 2.5% oral suspension for the treatment of bacterial lower urinary tract infections in cats." J Vet Intern Med 21(5): 990-5.
>> PubMed abstract

More on cat health: Winn Feline Foundation Library

Read More