Feline Entropion

Williams, D and J.-Y. Kim. Feline entropion: a case series of 50 affected animals (2003-2008). Veterinary Ophthalmology, 2009. 12(4):221-226.

Entropion is the inward rolling of all or part of an eyelid. The cornea and conjunctiva are irritated by hairs on the eyelid causing problems from mild discomfort and tearing to chronic pain and eye injury. Entropion is more common in dogs than cats, but may be under-recognized in cats. In this study from the U.K., 50 cats with entropion were examined. About 1/3 of the cats had a mean age of 4 years, while the remainder of the cats were relatively older, with a mean age of 11 years. Among the younger cats, entropion was likely to be caused by a pre-existing irritative disorder, such as conjunctivitis or corneal ulceration. In the group of older cats, lid laxity or enophthalmos were more likely causes. Persian cats represented 10% and Maine Coons represented 6% of the study group. Among these cats, involutional entropion was likely caused by anatomic problems. All cats were treated surgically with a Hotz-Celsus procedure, and the results were evaluated from 4 to 22 weeks later. Surgical treatment was curative in the majority of cases. [SL]
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Related articles:
Read RA, Broun HC. Entropion correction in dogs and cats using a combination Hotz-Celsus and lateral eyelid wedge resection: results in 311 eyes. Vet Ophthalmol. 2007 Jan-Feb;10(1):6-11.
>> PubMed Abstract

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Williams, D and J.-Y. Kim. Feline entropion: a case series of 50 affected animals (2003-2008). Veterinary Ophthalmology, 2009. 12(4):221-226.

Entropion is the inward rolling of all or part of an eyelid. The cornea and conjunctiva are irritated by hairs on the eyelid causing problems from mild discomfort and tearing to chronic pain and eye injury. Entropion is more common in dogs than cats, but may be under-recognized in cats. In this study from the U.K., 50 cats with entropion were examined. About 1/3 of the cats had a mean age of 4 years, while the remainder of the cats were relatively older, with a mean age of 11 years. Among the younger cats, entropion was likely to be caused by a pre-existing irritative disorder, such as conjunctivitis or corneal ulceration. In the group of older cats, lid laxity or enophthalmos were more likely causes. Persian cats represented 10% and Maine Coons represented 6% of the study group. Among these cats, involutional entropion was likely caused by anatomic problems. All cats were treated surgically with a Hotz-Celsus procedure, and the results were evaluated from 4 to 22 weeks later. Surgical treatment was curative in the majority of cases. [SL]
>> PubMed Abstract

Related articles:
Read RA, Broun HC. Entropion correction in dogs and cats using a combination Hotz-Celsus and lateral eyelid wedge resection: results in 311 eyes. Vet Ophthalmol. 2007 Jan-Feb;10(1):6-11.
>> PubMed Abstract

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Investigating the Genetic Causes of HCM

Meurs, K.M., et al., Analysis of 8 sarcomeric candidate genes for feline hypertrophic cardiomyopathy mutations in cats with hypertrophic cardiomyopathy. J Vet Intern Med, 2009. 23(4): p. 840-3.

The most common heart disease in cats is hypertrophic cardiomyopathy (HCM). A causative mutation has been identified in two breeds, the Maine Coon (MC) and Ragdoll that involve the cardiac myosin binding protein C gene (MYBPC3). HCM is thought to be inherited in other breeds as well. The objective of the study was to evaluate a subset of cats from additional breeds with HCM including the British Shorthair (BSH), Norwegian Forest Cat (NWF), Siberian, and Sphynx and to also examine MC cats known to be affected with HCM but lacking the known mutation. Fourteen affected cats among these breeds were evaluated. A causative mutation was not identified in the eight candidate genes studied, although several single nucleotide polymorphisms were detected. The study concluded that mutations within these cardiac genes do not appear to be the only cause of HCM in these breeds. Further evaluation of additional cardiac genes is considered warranted. (VT)
>> PubMed Abstract

Related articles:
Meurs, K.M., et al., A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy. Genomics, 2007. 90(2): p. 261-4.
>> PubMed Abstract

Meurs, K., et al., A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy. Hum Mol Genet, 2005. 14(23): p. 3587-3593.
>> PubMed Abstract

More on cat health: Winn Feline Foundation Library
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Meurs, K.M., et al., Analysis of 8 sarcomeric candidate genes for feline hypertrophic cardiomyopathy mutations in cats with hypertrophic cardiomyopathy. J Vet Intern Med, 2009. 23(4): p. 840-3.

The most common heart disease in cats is hypertrophic cardiomyopathy (HCM). A causative mutation has been identified in two breeds, the Maine Coon (MC) and Ragdoll that involve the cardiac myosin binding protein C gene (MYBPC3). HCM is thought to be inherited in other breeds as well. The objective of the study was to evaluate a subset of cats from additional breeds with HCM including the British Shorthair (BSH), Norwegian Forest Cat (NWF), Siberian, and Sphynx and to also examine MC cats known to be affected with HCM but lacking the known mutation. Fourteen affected cats among these breeds were evaluated. A causative mutation was not identified in the eight candidate genes studied, although several single nucleotide polymorphisms were detected. The study concluded that mutations within these cardiac genes do not appear to be the only cause of HCM in these breeds. Further evaluation of additional cardiac genes is considered warranted. (VT)
>> PubMed Abstract

Related articles:
Meurs, K.M., et al., A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy. Genomics, 2007. 90(2): p. 261-4.
>> PubMed Abstract

Meurs, K., et al., A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy. Hum Mol Genet, 2005. 14(23): p. 3587-3593.
>> PubMed Abstract

More on cat health: Winn Feline Foundation Library
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Prevalence of a Genetic Mutation for HCM in Maine Coon Cats

Fries, R., A. M. Heaney, et al. (2008). "Prevalence of the myosin-binding protein C mutation in Maine Coon cats." J Vet Intern Med 22(4): 893-896.

The most common cardiac disease of cats is hypertrophic cardiomyopathy (HCM). In several cat breeds, including the Maine Coon, the disease is inherited as an autosomal dominant trait. Previously, a single base pair change in the myosin-binding protein C (MYBPC3) gene, which changes a conserved amino acid and alters protein conformation, was been identified in some Maine Coon cats with HCM. The prevalence of the MYBPC3 mutation in the Maine Coon cat population is not known, but genetic screening has allowed determination of the percentage of genetically affected cats worldwide. This retrospective study reviewed records of 3,310 samples submitted for evaluation of the Maine Coon MYBPC3 mutation to the Veterinary Cardiac Genetics Laboratory database at Washington State University. In this population of cats, Maine Coons accounted for all the samples positive for this mutation. The worldwide percentage of Maine Coon cats carrying the MYBPC3 mutation was 34%.
>> PubMed Abstract

Related articles:
Meurs, K., X. Sanchez, et al. (2005). "A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy." Hum Mol Genet 14(23): 3587-3593.
>> Free full text article

More on cat health: Winn Feline Foundation Library

Fries, R., A. M. Heaney, et al. (2008). "Prevalence of the myosin-binding protein C mutation in Maine Coon cats." J Vet Intern Med 22(4): 893-896.

The most common cardiac disease of cats is hypertrophic cardiomyopathy (HCM). In several cat breeds, including the Maine Coon, the disease is inherited as an autosomal dominant trait. Previously, a single base pair change in the myosin-binding protein C (MYBPC3) gene, which changes a conserved amino acid and alters protein conformation, was been identified in some Maine Coon cats with HCM. The prevalence of the MYBPC3 mutation in the Maine Coon cat population is not known, but genetic screening has allowed determination of the percentage of genetically affected cats worldwide. This retrospective study reviewed records of 3,310 samples submitted for evaluation of the Maine Coon MYBPC3 mutation to the Veterinary Cardiac Genetics Laboratory database at Washington State University. In this population of cats, Maine Coons accounted for all the samples positive for this mutation. The worldwide percentage of Maine Coon cats carrying the MYBPC3 mutation was 34%.
>> PubMed Abstract

Related articles:
Meurs, K., X. Sanchez, et al. (2005). "A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy." Hum Mol Genet 14(23): 3587-3593.
>> Free full text article

More on cat health: Winn Feline Foundation Library

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Spironolactone in Cats With Heart Disease

Macdonald, K. A., M. D. Kittleson, et al. (2008). "Effect of spironolactone on diastolic function and left ventricular mass in Maine Coon cats with familial hypertrophic cardiomyopathy." J Vet Intern Med 22(2): 335-41.

Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease affecting the left ventricle. Some of the pathologic abnormalities found in HCM are myocardial fibrosis and concentric hypertrophy. Treatments that would reverse these pathologic changes would be beneficial. In a rat model of HCM, spironolactone reversed interstitial fibrosis, decreased myocyte disarray by 50%, and improved diastolic function within 10 weeks of treatment. The goal of this study was to evaluate spironolactone treatment of Maine Coon cats with HCM for its ability to improve diastolic function and reduce left ventricular mass. The study enrolled 26 Maine Coon cats with familial HCM and randomized them into two groups. One group received spironolactone (2 mg/kg, PO, BID) and the other group received placebo for 4 months. No significant treatment effect on cardiac function or left ventricular mass was identified. Severe facial dermatitis developed in 4 of the 13 cats receiving spironolactone, requiring discontinuation of therapy.

>> PubMed abstract

Related articles:

Winn funded research

Meurs, K., X. Sanchez, et al. (2005). "A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy." Hum Mol Genet 14(23): 3587-3593.

>> PubMed abstract

More on cat health: Winn Feline Foundation Library

Macdonald, K. A., M. D. Kittleson, et al. (2008). "Effect of spironolactone on diastolic function and left ventricular mass in Maine Coon cats with familial hypertrophic cardiomyopathy." J Vet Intern Med 22(2): 335-41.

Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease affecting the left ventricle. Some of the pathologic abnormalities found in HCM are myocardial fibrosis and concentric hypertrophy. Treatments that would reverse these pathologic changes would be beneficial. In a rat model of HCM, spironolactone reversed interstitial fibrosis, decreased myocyte disarray by 50%, and improved diastolic function within 10 weeks of treatment. The goal of this study was to evaluate spironolactone treatment of Maine Coon cats with HCM for its ability to improve diastolic function and reduce left ventricular mass. The study enrolled 26 Maine Coon cats with familial HCM and randomized them into two groups. One group received spironolactone (2 mg/kg, PO, BID) and the other group received placebo for 4 months. No significant treatment effect on cardiac function or left ventricular mass was identified. Severe facial dermatitis developed in 4 of the 13 cats receiving spironolactone, requiring discontinuation of therapy.

>> PubMed abstract

Related articles:

Winn funded research

Meurs, K., X. Sanchez, et al. (2005). "A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy." Hum Mol Genet 14(23): 3587-3593.

>> PubMed abstract

More on cat health: Winn Feline Foundation Library

Read More