Lowe, A. D., K. L. Campbell, et al. (2008). "Clinical, clinicopathological and histological changes observed in 14 cats treated with glucocorticoids." Vet Rec 162(24): 777-83.
Glucocorticoids such as prednisone and prednisolone are commonly used to treat a variety of conditions in feline medicine. Adverse effects from this class of drugs in cats are well known, and may be dose-dependent. In this study, 14 cats were given immunosuppressive doses of prednisolone (4.4 mg/kg/day) or dexamethasone (0.55 mg/kg/day) for 8 weeks. Complete blood counts, serum biochemistry profiles and urinalyses were performed on days 0 and 56, and liver biopsies were taken on day 56. Significant increases were noted in mean white blood cell counts, neutrophil counts, and monocyte counts. Significant decreases were noted in mean lymphocyte counts and eosinophil counts. Consistent increases in serum albumin, glucose, triglycerides and cholesterol were observed. A steroid hepatopathy was present in varying degrees in all liver biopsies. One cat developed clinical signs believed to be related to the therapy, such as icterus and curling of the pinnae.
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Related articles:
Sharkey, L. C., T. Ployngam, et al. (2007). "Effects of a single injection of methylprednisolone acetate on serum biochemical parameters in 11 cats." Vet Clin Pathol 36(2): 184-7.
>> PubMed Abstract
More on cat health: Winn Feline Foundation Library
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