FIV and Papillomavirus

Munday JS, Witham AI: Frequent detection of papillomavirus DNA in clinically normal skin of cats infected and noninfected with feline immunodeficiency virus, Vet Dermatol 21:307, 2010.

Feline squamous cell carcinomas (SCC), a type of skin cancer, often have evidence of infection with feline papillomavirus (FPV); it is not known if the virus contributes to cancer development in cats. Cats infected with feline immunodeficiency virus (FIV) have a higher incidence of SCC, perhaps due to increased FPV infection. This study examined the rate of FPV infection in healthy cats (without SCC), and compared this rate in FIV-free (n=22), and FIV-infected cats (n=22). The investigators found that 52% of cats tested positive for FPV; no difference was found in FIV-infected versus uninfected cats. In addition, both FPV-infected and uninfected cats were found within single households, indicating exposure does not necessarily lead to infection. The investigators concluded that while FPV infection in asymptomatic cats is common, a link with SCC could not be shown. [MK]


Related articles:
Munday JS, Dunowska M, De Grey S: Detection of two different papillomaviruses within a feline cutaneous squamous cell carcinoma: case report and review of the literature, N Z Vet J 57:248, 2009.

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Munday JS, Witham AI: Frequent detection of papillomavirus DNA in clinically normal skin of cats infected and noninfected with feline immunodeficiency virus, Vet Dermatol 21:307, 2010.

Feline squamous cell carcinomas (SCC), a type of skin cancer, often have evidence of infection with feline papillomavirus (FPV); it is not known if the virus contributes to cancer development in cats. Cats infected with feline immunodeficiency virus (FIV) have a higher incidence of SCC, perhaps due to increased FPV infection. This study examined the rate of FPV infection in healthy cats (without SCC), and compared this rate in FIV-free (n=22), and FIV-infected cats (n=22). The investigators found that 52% of cats tested positive for FPV; no difference was found in FIV-infected versus uninfected cats. In addition, both FPV-infected and uninfected cats were found within single households, indicating exposure does not necessarily lead to infection. The investigators concluded that while FPV infection in asymptomatic cats is common, a link with SCC could not be shown. [MK]


Related articles:
Munday JS, Dunowska M, De Grey S: Detection of two different papillomaviruses within a feline cutaneous squamous cell carcinoma: case report and review of the literature, N Z Vet J 57:248, 2009.

More on cat health: Winn Feline Foundation Library
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Feline Squamous Cell Carcinoma: Role of Papillomavirus

Munday, J.S., M. Dunowska, and S. De Grey, Detection of two different papillomaviruses within a feline cutaneous squamous cell carcinoma: case report and review of the literature. N Z Vet J, 2009. 57(4): p. 248-51.

Squamous cell carcinomas (SCC) are among the most common malignant skin cancers of cats. There is evidence that papillomaviruses promote SCC development on sun-exposed areas in humans. About 100 papillomaviruses are known in humans, but only a few in dogs and cats. Previous reports have identified papillomaviruses in a certain proportion of canine SCC. This paper describes the identification (using PCR) of viral DNA from two distinct papillomaviruses in an invasive SCC on the nose of a 15-year-old cat. One of the two viruses has never been described before. It is also the first time that multiple papillomaviruses have been detected in a single cancerous lesion in a cat. This finding supports the association between papillomaviruses and SCC in cats. If papillomaviruses influence the development of feline SCC, new approaches to treatment may be possible. [MK]
>> PubMed Abstract

Related articles:
Munday, J.S., et al., Detection of papillomaviral sequences in feline Bowenoid in situ carcinoma using consensus primers. Vet Dermatol, 2007. 18(4): p. 241-5.
>> PubMed Abstract

Zaugg, N., et al., Detection of novel papillomaviruses in canine mucosal, cutaneous and in situ squamous cell carcinomas. Vet Dermatol, 2005. 16(5): p. 290-8.
>> PubMed Abstract

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Munday, J.S., M. Dunowska, and S. De Grey, Detection of two different papillomaviruses within a feline cutaneous squamous cell carcinoma: case report and review of the literature. N Z Vet J, 2009. 57(4): p. 248-51.

Squamous cell carcinomas (SCC) are among the most common malignant skin cancers of cats. There is evidence that papillomaviruses promote SCC development on sun-exposed areas in humans. About 100 papillomaviruses are known in humans, but only a few in dogs and cats. Previous reports have identified papillomaviruses in a certain proportion of canine SCC. This paper describes the identification (using PCR) of viral DNA from two distinct papillomaviruses in an invasive SCC on the nose of a 15-year-old cat. One of the two viruses has never been described before. It is also the first time that multiple papillomaviruses have been detected in a single cancerous lesion in a cat. This finding supports the association between papillomaviruses and SCC in cats. If papillomaviruses influence the development of feline SCC, new approaches to treatment may be possible. [MK]
>> PubMed Abstract

Related articles:
Munday, J.S., et al., Detection of papillomaviral sequences in feline Bowenoid in situ carcinoma using consensus primers. Vet Dermatol, 2007. 18(4): p. 241-5.
>> PubMed Abstract

Zaugg, N., et al., Detection of novel papillomaviruses in canine mucosal, cutaneous and in situ squamous cell carcinomas. Vet Dermatol, 2005. 16(5): p. 290-8.
>> PubMed Abstract

More on cat health: Winn Feline Foundation Library
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Feline Papillomavirus

Munday, J. S., L. Howe, et al. (2008). "Detection of papillomaviral DNA sequences in a feline oral squamous cell carcinoma." Res Vet Sci 86(2): 359-361.

Oral squamous cell carcinomas constitute 7.5% of all feline cancers, and often lead to death in affected cats. In humans, these tumors are associated with papillomavirus in about 25% of the cases. To investigate the association of papillomavirus with feline oral tumors, 40 oral lesions (20 cancerous, 20 non-cancerous) were examined for viral DNA. Papillomaviral DNA was detected in one oral tumor, but not in any non-cancerous lesion. Finding viral DNA in only one tumor did not indicate a causal relationship. The finding of viral DNA does however indicate additional research into the carcinogenic potential of these viruses in cats is warranted; the carcinogenic potential of papillomaviruses in general and the finding here of viral DNA in a feline oral tumor hints at a possible role. [MK]
>> PubMed Abstract

Related articles:
Munday, J. S., M. Kiupel, et al. (2007). "Detection of papillomaviral sequences in feline Bowenoid in situ carcinoma using consensus primers." Vet Dermatol 18(4): 241-5.
>> PubMed Abstract

Sundberg, J., M. Van Ranst, et al. (2000). "Feline papillomas and papillomaviruses." Vet Pathol 37(1): 1-10.
>> PubMed Abstact

More on cat health: Winn Feline Foundation Library
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Munday, J. S., L. Howe, et al. (2008). "Detection of papillomaviral DNA sequences in a feline oral squamous cell carcinoma." Res Vet Sci 86(2): 359-361.

Oral squamous cell carcinomas constitute 7.5% of all feline cancers, and often lead to death in affected cats. In humans, these tumors are associated with papillomavirus in about 25% of the cases. To investigate the association of papillomavirus with feline oral tumors, 40 oral lesions (20 cancerous, 20 non-cancerous) were examined for viral DNA. Papillomaviral DNA was detected in one oral tumor, but not in any non-cancerous lesion. Finding viral DNA in only one tumor did not indicate a causal relationship. The finding of viral DNA does however indicate additional research into the carcinogenic potential of these viruses in cats is warranted; the carcinogenic potential of papillomaviruses in general and the finding here of viral DNA in a feline oral tumor hints at a possible role. [MK]
>> PubMed Abstract

Related articles:
Munday, J. S., M. Kiupel, et al. (2007). "Detection of papillomaviral sequences in feline Bowenoid in situ carcinoma using consensus primers." Vet Dermatol 18(4): 241-5.
>> PubMed Abstract

Sundberg, J., M. Van Ranst, et al. (2000). "Feline papillomas and papillomaviruses." Vet Pathol 37(1): 1-10.
>> PubMed Abstact

More on cat health: Winn Feline Foundation Library
Join us on Facebook

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