UK team gets $1.5 million NIH grant to continue success with cell-level study of Alzheimer's disease factor

University of Kentucky researchers have provided the first direct evidence that activated astrocytes could play a harmful role in Alzheimer's disease.

A UK news release explains, "The astrocyte is a very abundant non-neuronal cell type that performs absolutely critical functions for maintaining healthy nervous tissue. However, in neurodegenerative diseases, like Alzheimer’s disease, many astrocytes exhibit clear physical changes often referred to as 'astrocyte activation.' The appearance of activated astrocytes at very early stages of Alzheimer's has led to the idea that astrocytes contribute to the emergence and/or maintenance of other pathological markers of the disease."

UK researchers gave mice gene therapy at a very young age and assessed them 10 months later. The astrocyte activation improved brain function and preserved cognitive function. The research, published recently in the Journal of Neuroscience, has led to a five-year, $1.5 million National Institutes of Health funding grant to the researchers and the UK Sanders-Brown Center on Aging to further this line of study. Chris Norris, an associate professor in the UK College of Medicine Department of Molecular and Biomedical Pharmacology, is the senior author of the study. (Read more)
 

University of Kentucky researchers have provided the first direct evidence that activated astrocytes could play a harmful role in Alzheimer's disease.

A UK news release explains, "The astrocyte is a very abundant non-neuronal cell type that performs absolutely critical functions for maintaining healthy nervous tissue. However, in neurodegenerative diseases, like Alzheimer’s disease, many astrocytes exhibit clear physical changes often referred to as 'astrocyte activation.' The appearance of activated astrocytes at very early stages of Alzheimer's has led to the idea that astrocytes contribute to the emergence and/or maintenance of other pathological markers of the disease."

UK researchers gave mice gene therapy at a very young age and assessed them 10 months later. The astrocyte activation improved brain function and preserved cognitive function. The research, published recently in the Journal of Neuroscience, has led to a five-year, $1.5 million National Institutes of Health funding grant to the researchers and the UK Sanders-Brown Center on Aging to further this line of study. Chris Norris, an associate professor in the UK College of Medicine Department of Molecular and Biomedical Pharmacology, is the senior author of the study. (Read more)
 

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More bad news about childhood obesity: Study finds it can change some kids' brains and damage their mental 'flexibility'

It's not news that Kentucky is lagging in child fitness. In fact, the Truth for America's Health "F as in Fat" report found that the state has the third highest childhood obesity rate in the country. This is bad news, alright, and it's about to get worse. Dr. Claire McCarthy writes in The Boston Globe that a new study in the current issue of Pediatrics and shows that obesity can hurt kids' brains.

"Researchers looked at 49 adolescents with metabolic syndrome. Metabolic syndrome, a consequence of obesity, is the triad of insulin resistance (pre-diabetes or diabetes), high blood pressure and high blood lipids," McCarthy writes. "The researchers compared the adolescents with 62 adolescents who had the same socioeconomic background but didn't have metabolic syndrome. The kids with metabolic syndrome had more trouble with arithmetic, spelling, attention and mental 'flexibility' than the ones who didn't have metabolic syndrome. Even more frightening, the researchers saw actual changes in their brains, in the hippocampus (which plays a crucial role in memory) and the white matter (which passes messages through the brain). It was only a small study, and not all kids with obesity have metabolic syndrome. But this study is alarming -- especially since we don't know if losing weight can make the brain go back to normal."

In her column tagged "MD Mama," McCarthy goes on: "Given that brains are still developing in adolescence, it's very possible that the changes could be permanent. What else do we need before we take the problem of childhood obesity really seriously?" (Read more) To read the study in Pedatrics, go here.

It's not news that Kentucky is lagging in child fitness. In fact, the Truth for America's Health "F as in Fat" report found that the state has the third highest childhood obesity rate in the country. This is bad news, alright, and it's about to get worse. Dr. Claire McCarthy writes in The Boston Globe that a new study in the current issue of Pediatrics and shows that obesity can hurt kids' brains.

"Researchers looked at 49 adolescents with metabolic syndrome. Metabolic syndrome, a consequence of obesity, is the triad of insulin resistance (pre-diabetes or diabetes), high blood pressure and high blood lipids," McCarthy writes. "The researchers compared the adolescents with 62 adolescents who had the same socioeconomic background but didn't have metabolic syndrome. The kids with metabolic syndrome had more trouble with arithmetic, spelling, attention and mental 'flexibility' than the ones who didn't have metabolic syndrome. Even more frightening, the researchers saw actual changes in their brains, in the hippocampus (which plays a crucial role in memory) and the white matter (which passes messages through the brain). It was only a small study, and not all kids with obesity have metabolic syndrome. But this study is alarming -- especially since we don't know if losing weight can make the brain go back to normal."

In her column tagged "MD Mama," McCarthy goes on: "Given that brains are still developing in adolescence, it's very possible that the changes could be permanent. What else do we need before we take the problem of childhood obesity really seriously?" (Read more) To read the study in Pedatrics, go here.

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