Cyclosporine in cats

Final report, Winn grant W09-028
Pharmacokinetics of cyclosporine after intravenous and subcutaneous administration in cats
Investigators: Sandra Diaz, David Panciera, James Meldrum; Virginia_Maryland Regional College of Veterinary Medicine

Cyclosporine A (CsA) is an immune-modulating drug that has traditionally been used for kidney transplantation in cats. In recent years, CsA has been reported to be effective in the management of several skin diseases, including allergic skin disease. CsA is typically given by mouth, but absorption of the drug is variable and not all owners can give oral medication to their cats long term. The objective of this study was to determine if subcutaneous administration of CsA would give predictable blood concentrations of the drug. If so, this route of drug administration could be easier for some cat owners, and may reduce side effects and reduce the need for blood monitoring of drug levels.

This study looked at the pharmacokinetic profile of CsA after intravenous (IV) and subcutaneous (SQ) administration. Five healthy adult cats were given a single IV bolus of CsA. After two weeks, they received a dose of CsA SQ every 48 hours for 14 days. Blood samples were taken and measured. No adverse effects were observed in any cat. The results indicated that SQ CsA bioavailability is very good. The SQ route could represent a promising route of administration in cats in the future. [VT]

See also: Heinrich NA, McKeever PJ and Eisenschenk MC. Adverse events in 50 cats with allergic dermatitis receiving ciclosporin. Vet Dermatol. 2011; 22: 511-20.

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Final report, Winn grant W09-028
Pharmacokinetics of cyclosporine after intravenous and subcutaneous administration in cats
Investigators: Sandra Diaz, David Panciera, James Meldrum; Virginia_Maryland Regional College of Veterinary Medicine

Cyclosporine A (CsA) is an immune-modulating drug that has traditionally been used for kidney transplantation in cats. In recent years, CsA has been reported to be effective in the management of several skin diseases, including allergic skin disease. CsA is typically given by mouth, but absorption of the drug is variable and not all owners can give oral medication to their cats long term. The objective of this study was to determine if subcutaneous administration of CsA would give predictable blood concentrations of the drug. If so, this route of drug administration could be easier for some cat owners, and may reduce side effects and reduce the need for blood monitoring of drug levels.

This study looked at the pharmacokinetic profile of CsA after intravenous (IV) and subcutaneous (SQ) administration. Five healthy adult cats were given a single IV bolus of CsA. After two weeks, they received a dose of CsA SQ every 48 hours for 14 days. Blood samples were taken and measured. No adverse effects were observed in any cat. The results indicated that SQ CsA bioavailability is very good. The SQ route could represent a promising route of administration in cats in the future. [VT]

See also: Heinrich NA, McKeever PJ and Eisenschenk MC. Adverse events in 50 cats with allergic dermatitis receiving ciclosporin. Vet Dermatol. 2011; 22: 511-20.

More on cat health: Winn Feline Foundation Library
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Cetirizine For Allergies in Cats

Papich, M. G., E. K. Schooley, et al. (2008). "Pharmacokinetics of cetirizine in healthy cats." Am J Vet Res 69(5): 670-4.

Cats may suffer from various manifestations of allergic disease affecting body systems such as the skin, respiratory tract, and gastrointestinal tract. Glucocorticoids such as prednisone are effective for treating allergic disease in cats, but may be associated with undesirable adverse effects. Cetirizine (Zyrtec, Pfizer), a second-generation antihistamine, is effective in humans for treatment of allergic symptoms and appears to have less adverse effects than first-generation antihistamines. Although there is anecdotal information about the use of cetirizine in cats, no published pharmacokinetic studies exist and an appropriate oral dose has not been established. In this study, the pharmacokinetic characteristics of cetirizine after oral administration of a single dose was characterized in cats. Each of nine healthy cats was given a single oral dose of 5 mg cetirizine. Blood samples were collected at various time points up to 24 hours after administration and plasma concentrations of cetirizine were analyzed. Cats given this single oral dose of cetirizine had high plasma concentrations compared with those reported in humans, a long halflife, and lack of detectable adverse effects. The results support once daily dosing of cetirizine in cats. Further studies evaluating the therapeutic efficacy of this drug in cats with allergic disease need to be performed, as well as multipledose pharmacokinetic and safety studies. It appears that cetirizine may be a useful alternative to glucocorticoids in cats with allergic disease.
>> PubMed abstract

More on cat health: Winn Feline Foundation Library

Papich, M. G., E. K. Schooley, et al. (2008). "Pharmacokinetics of cetirizine in healthy cats." Am J Vet Res 69(5): 670-4.

Cats may suffer from various manifestations of allergic disease affecting body systems such as the skin, respiratory tract, and gastrointestinal tract. Glucocorticoids such as prednisone are effective for treating allergic disease in cats, but may be associated with undesirable adverse effects. Cetirizine (Zyrtec, Pfizer), a second-generation antihistamine, is effective in humans for treatment of allergic symptoms and appears to have less adverse effects than first-generation antihistamines. Although there is anecdotal information about the use of cetirizine in cats, no published pharmacokinetic studies exist and an appropriate oral dose has not been established. In this study, the pharmacokinetic characteristics of cetirizine after oral administration of a single dose was characterized in cats. Each of nine healthy cats was given a single oral dose of 5 mg cetirizine. Blood samples were collected at various time points up to 24 hours after administration and plasma concentrations of cetirizine were analyzed. Cats given this single oral dose of cetirizine had high plasma concentrations compared with those reported in humans, a long halflife, and lack of detectable adverse effects. The results support once daily dosing of cetirizine in cats. Further studies evaluating the therapeutic efficacy of this drug in cats with allergic disease need to be performed, as well as multipledose pharmacokinetic and safety studies. It appears that cetirizine may be a useful alternative to glucocorticoids in cats with allergic disease.
>> PubMed abstract

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Yeast Overgrowth in Cats With Allergic Skin Disease

Ordeix, L., F. Galeotti, et al. (2007). "Malassezia spp. overgrowth in allergic cats." Vet Dermatol 18(5): 316-23.

Malassezia (formerly known as Pityrosporum) are yeasts found on the skin surface of animals and humans. A series of 18 cats with skin disease is reported; 16 of which were diagnosed with atopic dermatitis. All were diagnosed with overgrowth of Malassezia on cytological examination or fungal culture. Skin lesions included multifocal alopecia, erythema, crusting and greasy adherent brownish scales. Treatment consisted of antifungal therapy alone, antifungal plus antibacterial therapy, or antifungal, antibacterial and anti-inflammatory therapy. After 3 to 4 weeks, substantial improvement was seen in all cats treated with combination therapy, and in 71% of cats treated with antifungal therapy alone. Malassezia overgrowth may be a secondary problem in some allergic cats, especially those with greasy adherent brownish scales.
>> PubMed abtract

Related article:
Ahman, S., N. Perrins, et al. (2007). "Treatment of Malassezia pachydermatis-associated seborrhoeic dermatitis in Devon Rex cats with itraconazole--a pilot study." Vet Dermatol 18(3): 171-4.

More on cat health: Winn Feline Foundation Library

Ordeix, L., F. Galeotti, et al. (2007). "Malassezia spp. overgrowth in allergic cats." Vet Dermatol 18(5): 316-23.

Malassezia (formerly known as Pityrosporum) are yeasts found on the skin surface of animals and humans. A series of 18 cats with skin disease is reported; 16 of which were diagnosed with atopic dermatitis. All were diagnosed with overgrowth of Malassezia on cytological examination or fungal culture. Skin lesions included multifocal alopecia, erythema, crusting and greasy adherent brownish scales. Treatment consisted of antifungal therapy alone, antifungal plus antibacterial therapy, or antifungal, antibacterial and anti-inflammatory therapy. After 3 to 4 weeks, substantial improvement was seen in all cats treated with combination therapy, and in 71% of cats treated with antifungal therapy alone. Malassezia overgrowth may be a secondary problem in some allergic cats, especially those with greasy adherent brownish scales.
>> PubMed abtract

Related article:
Ahman, S., N. Perrins, et al. (2007). "Treatment of Malassezia pachydermatis-associated seborrhoeic dermatitis in Devon Rex cats with itraconazole--a pilot study." Vet Dermatol 18(3): 171-4.

More on cat health: Winn Feline Foundation Library

Read More