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Showing posts with label Bengal. Show all posts
Showing posts with label Bengal. Show all posts

Friday, July 20, 2012

Chest deformities in Bengal kittens

Charlesworth TM, Sturgess CP. Increased incidence of thoracic wall deformities in related Bengal kittens. J Feline Med Surg 2012;14:365-368.



There are several thoracic wall deformities described in kittens, including pectus excavatum (PE), flat-chest defect, scoliosis, lordosis, kyphosis, pectus carinatum, and missing or extra ribs or thoracic vertebrae. In this study, clinical records made during examinations for routine vaccinations were evaluated in populations of domestic shorthair (DSH) kittens and Bengal kittens. The records for 244 Bengal kittens were reviewed and compared to those of 1748 DSH kittens. No thoracic wall abnormalities were recorded in the DSH kittens compared with 12 cases in the Bengal kittens. Among the 12 cases in Bengal kittens, the deformities detected were pectus excavatum (5), unilateral thoracic wall concavity (6), and scoliosis (1). There was a high degree of common ancestry found in analyzing five-generation pedigrees and this indicates a familial cause is likely. The data presented supports the hypothesis that these deformities are more common within the study’s examined population of Bengal kittens than a DSH population. Data also suggests that thoracic wall deformities may be a relatively common familial defect in Bengal kittens. Bengal kittens should have their thoracic wall carefully evaluated during routine clinical evaluation. [VT]

See also: Yoon H, Mann F, Jeong S. Surgical correction of pectus excavatum in two cats. J Vet Sci 2008;9:335-337. [free, full text article]

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Charlesworth TM, Sturgess CP. Increased incidence of thoracic wall deformities in related Bengal kittens. J Feline Med Surg 2012;14:365-368.



There are several thoracic wall deformities described in kittens, including pectus excavatum (PE), flat-chest defect, scoliosis, lordosis, kyphosis, pectus carinatum, and missing or extra ribs or thoracic vertebrae. In this study, clinical records made during examinations for routine vaccinations were evaluated in populations of domestic shorthair (DSH) kittens and Bengal kittens. The records for 244 Bengal kittens were reviewed and compared to those of 1748 DSH kittens. No thoracic wall abnormalities were recorded in the DSH kittens compared with 12 cases in the Bengal kittens. Among the 12 cases in Bengal kittens, the deformities detected were pectus excavatum (5), unilateral thoracic wall concavity (6), and scoliosis (1). There was a high degree of common ancestry found in analyzing five-generation pedigrees and this indicates a familial cause is likely. The data presented supports the hypothesis that these deformities are more common within the study’s examined population of Bengal kittens than a DSH population. Data also suggests that thoracic wall deformities may be a relatively common familial defect in Bengal kittens. Bengal kittens should have their thoracic wall carefully evaluated during routine clinical evaluation. [VT]

See also: Yoon H, Mann F, Jeong S. Surgical correction of pectus excavatum in two cats. J Vet Sci 2008;9:335-337. [free, full text article]

More on cat health:
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Monday, May 14, 2012

Inherited blindness in Bengal cats

Winn grant W12-022
Molecular characterization of Bengal progressive retinal atrophy
Investigator: Robert A. Grahn; University of California, Davis
 
Inherited blindness is a devastating disease common to many species. In people, over 25 different forms of inherited retinal blindness have been clinically characterized. Cats also have several forms of blindness that destroy the photoreceptors at the back of the eye. These conditions will randomly occur in a particular cat breed and then will be inherited. Some forms of blindness attack the photoreceptors shortly after birth, while other forms take longer to destroy vision. Several Bengal cats have been diagnosed with a form of blindness that destroys their vision at around 5 months of age. A genome wide association case control study has indicated a candidate region for a possible mutation causing progressive retinal atrophy in the Bengal breed. This proposal will obtain the sequence of the RNA and DNA of this candidate gene to identify the mutation and allow for development of a genetic test to help reduce the prevalence of the disease in the Bengal breed.

This study has received partial funding from Winn according to our guidelines for breed-specific projects. Please donate so that the project may be fully funded.

More on cat health:
Winn Feline Foundation Library
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Winn grant W12-022
Molecular characterization of Bengal progressive retinal atrophy
Investigator: Robert A. Grahn; University of California, Davis
 
Inherited blindness is a devastating disease common to many species. In people, over 25 different forms of inherited retinal blindness have been clinically characterized. Cats also have several forms of blindness that destroy the photoreceptors at the back of the eye. These conditions will randomly occur in a particular cat breed and then will be inherited. Some forms of blindness attack the photoreceptors shortly after birth, while other forms take longer to destroy vision. Several Bengal cats have been diagnosed with a form of blindness that destroys their vision at around 5 months of age. A genome wide association case control study has indicated a candidate region for a possible mutation causing progressive retinal atrophy in the Bengal breed. This proposal will obtain the sequence of the RNA and DNA of this candidate gene to identify the mutation and allow for development of a genetic test to help reduce the prevalence of the disease in the Bengal breed.

This study has received partial funding from Winn according to our guidelines for breed-specific projects. Please donate so that the project may be fully funded.

More on cat health:
Winn Feline Foundation Library
Find us on Facebook
Follow us on Twitter
Read the Cat Health News Weekly
Join us on Google+
Read More