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Wednesday, February 6, 2013

Physician assistants and some doctors urge lawmakers to pass bill that could ease provider shortage in rural Kentucky

Doctors and more than 150 physician-assistant students urged lawmakers Tuesday to pass a bill they stated involves dropping only one requirement in the law and could ease a physician shortage in Kentucky, reports Ryan Nick of cn|2's "Pure Politics."

Passage of Senate Bill 43 would repeal a law that allows physician assistants to treat patients only when a supervising physician is on site for the first 18 months after their certification. If passed, PAs would still be supervised but would be permitted to perform services in a location separate from the supervising physician, as long as that physician can be reached by phone at all times.

No other state requires PAs to have 18 months of on-site supervision. Colorado, the state with the next-longest mandate, requires supervision only for the first 1,000 hours after certification.

The bill's supporters say the burdensome supervision requirement has led to 55 out of Kentucky's 120 counties being medically underserved and has encouraged many PAs to practice in other states, reports Storm. They also say this rule needlessly complicates patient care, especially in rural areas where doctors are stretched thin, reports Melinda Beck of The Wall Street Journal.

The bill's sponsor, Sen. Tom Buford, R-Nicholasville, told Kentucky Health News that he expects the Kentucky Medical Association to seek some changes in the bill, but also expects it to pass because Senate Republican leaders, hospitals and universities support it. "We're educating these PAs at a lot of state expense just to work in other states," he said. House Speaker Greg Stumbo, D-Prestonsburg, told Storm he sees no reason why the bill shouldn't pass. Sen. Julie Denton, R-Louisville, chair of the Senate Health and Welfare Committee, told KHN that she supports the bill.

PAs are expected to be in even greater demand when the health-care reform law brings hundreds of thousands of Kentuckians into the health-insurance system. Beck notes the state is expected to face a greater shortage of physicians, particularly in primary care and rural areas. Buford said, "We're going to provide all this health care for everybody, and there's nobody to go see." For more from cn|2, including video interviews, click here.
Doctors and more than 150 physician-assistant students urged lawmakers Tuesday to pass a bill they stated involves dropping only one requirement in the law and could ease a physician shortage in Kentucky, reports Ryan Nick of cn|2's "Pure Politics."

Passage of Senate Bill 43 would repeal a law that allows physician assistants to treat patients only when a supervising physician is on site for the first 18 months after their certification. If passed, PAs would still be supervised but would be permitted to perform services in a location separate from the supervising physician, as long as that physician can be reached by phone at all times.

No other state requires PAs to have 18 months of on-site supervision. Colorado, the state with the next-longest mandate, requires supervision only for the first 1,000 hours after certification.

The bill's supporters say the burdensome supervision requirement has led to 55 out of Kentucky's 120 counties being medically underserved and has encouraged many PAs to practice in other states, reports Storm. They also say this rule needlessly complicates patient care, especially in rural areas where doctors are stretched thin, reports Melinda Beck of The Wall Street Journal.

The bill's sponsor, Sen. Tom Buford, R-Nicholasville, told Kentucky Health News that he expects the Kentucky Medical Association to seek some changes in the bill, but also expects it to pass because Senate Republican leaders, hospitals and universities support it. "We're educating these PAs at a lot of state expense just to work in other states," he said. House Speaker Greg Stumbo, D-Prestonsburg, told Storm he sees no reason why the bill shouldn't pass. Sen. Julie Denton, R-Louisville, chair of the Senate Health and Welfare Committee, told KHN that she supports the bill.

PAs are expected to be in even greater demand when the health-care reform law brings hundreds of thousands of Kentuckians into the health-insurance system. Beck notes the state is expected to face a greater shortage of physicians, particularly in primary care and rural areas. Buford said, "We're going to provide all this health care for everybody, and there's nobody to go see." For more from cn|2, including video interviews, click here.
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Tuesday, February 5, 2013

Kasich of Ohio is fifth Republican governor to accept Medicaid expansion; he and others cite need to protect rural hospitals, poor

Several Republican governors have decided to expand Medicaid under federal health-care reform, saying their conservative principles were outweighed by a need to protect their state's rural hospitals and low-income people. Yesterday, the governor of one of the biggest states got on the bandwagon.

John Kasich of Ohio joined Jan Brewer of Arizona, Brian Sandoval of Nevada, Susana Martinez of New Mexico and Jack Dalrymple of North Dakota in saying they will take heavy federal subsidies to expand the program to households with incomes up to 138 percent of the federal poverty threshold.

Democratic Gov. Steve Beshear of Kentucky has said he wants to expand Medicaid if Kentucky can afford it, and he expects to get cost estimates around the end of March.

While Kasich is not an "Obamacare" supporter, he said expanding Medicaid “makes great sense for Ohio” because it would save $235 million over the next two years and free about $100 million in local funds for mental-health and addiction services, reports The Columbus Dispatch.

Kasich said the decision could extend health coverage to as many as 578,000 uninsured Ohio residents, and could keep everyone else’s health insurance premiums down because there won’t be so many uninsured people going to emergency rooms for their medical care, reports David Nather of Politico.

Kasich emphasized that he would like to see the 2010 law repealed, but the federal money it would pump into the state — about $13 billion over the next seven years — was too much to pass up, reports Stateline. The federal government will pay the full cost of expansion through 2016; then  states will have to pitch in, rising to a limit of 10 percent by 2020.

Brewer likewise said it doesn't make sense for Arizona to pass up federal dollars, reports Howard Fischer of the Arizona Daily Sun. "We will protect rural and safety-net hospitals from being pushed to the brink by growing their cost in caring for the uninsured," Brewer said. She also said the expansion will create enormous economic benefit, inject $2 billion into the Arizona economy, save and create thousands of jobs and provide health care to hundreds of thousands of low-income individuals, reports Fischer.

Brewer said going along with expansion will save Arizona money because the costs of providing care to the uninsured are not simply absorbed by hospitals but passed along through increased insurance premiums. Supporters of the expansion hope the five Republicans' decisions will prompt more GOP governors to follow suit. Twenty governors from both political parties are still undecided. (Read more)


Several Republican governors have decided to expand Medicaid under federal health-care reform, saying their conservative principles were outweighed by a need to protect their state's rural hospitals and low-income people. Yesterday, the governor of one of the biggest states got on the bandwagon.

John Kasich of Ohio joined Jan Brewer of Arizona, Brian Sandoval of Nevada, Susana Martinez of New Mexico and Jack Dalrymple of North Dakota in saying they will take heavy federal subsidies to expand the program to households with incomes up to 138 percent of the federal poverty threshold.

Democratic Gov. Steve Beshear of Kentucky has said he wants to expand Medicaid if Kentucky can afford it, and he expects to get cost estimates around the end of March.

While Kasich is not an "Obamacare" supporter, he said expanding Medicaid “makes great sense for Ohio” because it would save $235 million over the next two years and free about $100 million in local funds for mental-health and addiction services, reports The Columbus Dispatch.

Kasich said the decision could extend health coverage to as many as 578,000 uninsured Ohio residents, and could keep everyone else’s health insurance premiums down because there won’t be so many uninsured people going to emergency rooms for their medical care, reports David Nather of Politico.

Kasich emphasized that he would like to see the 2010 law repealed, but the federal money it would pump into the state — about $13 billion over the next seven years — was too much to pass up, reports Stateline. The federal government will pay the full cost of expansion through 2016; then  states will have to pitch in, rising to a limit of 10 percent by 2020.

Brewer likewise said it doesn't make sense for Arizona to pass up federal dollars, reports Howard Fischer of the Arizona Daily Sun. "We will protect rural and safety-net hospitals from being pushed to the brink by growing their cost in caring for the uninsured," Brewer said. She also said the expansion will create enormous economic benefit, inject $2 billion into the Arizona economy, save and create thousands of jobs and provide health care to hundreds of thousands of low-income individuals, reports Fischer.

Brewer said going along with expansion will save Arizona money because the costs of providing care to the uninsured are not simply absorbed by hospitals but passed along through increased insurance premiums. Supporters of the expansion hope the five Republicans' decisions will prompt more GOP governors to follow suit. Twenty governors from both political parties are still undecided. (Read more)


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Weight loss not a fad - commit to eating right, it’s your new Natural Way!



 
Natural News is covering the best program ever for reaching your ideal weight and health, and keeping it that way for good! This is weight loss 101, this is the simple plan, the planned plan that works. This is the short and long term plan.

 

Forget about Atkins and South Beach and diet pills and dangerous meds or surgery. Forget about some diet fad that will make you sick, with artificial sweeteners and gluten and probably gelatin and “other ingredients” that give you IBS or central nervous system imbalance, like Aspartame does. Watch out for those weight watcher boxes of toxins too!! Danger Danger:

 


 


 


 

Forget about the No CARB thing, it doesn’t work. You can hurt your brain and body within 60 days on those. You can damage your memory too. Do some research on that, there is a lot out there.

 

Forget about starving yourself for a few days, it doesn’t work.

 

Forget about worrying about doing it right, because Mike Adams and Natural News keep it real, honest, researched and forthright. Look into this now, even if you just want to maintain the perfect weight and health, because maintenance is what it’s all about, not crazy dieting and then binging later.

 

Natural News actually helped expose two of the biggest ones in the last decade: the counterfeit hoodia scam, and the fake news acai weight loss scam.

Learn more: http://www.naturalnews.com/038968_weight_loss_supplements_fitness.html#ixzz2K3D0N2tS

 

Okay, so now you’ve dispelled the myths and you want the truth. How do you do this for now and for good? Here’s how:

 

LIQUID ALCHEMY: “The world's most potent serious weight management supplement. It's called Slimirexand it's a liquid combination of multiple plant extracts known for their beneficial effects on body weight.”

 


 

How does it work so well?

 Take the 10 question quiz and find out right now!
Learn more: http://www.naturalnews.com/038968_weight_loss_supplements_fitness.html#ixzz2K3DoX9hk

 

Product links:

 


 


 

 

 


 
Natural News is covering the best program ever for reaching your ideal weight and health, and keeping it that way for good! This is weight loss 101, this is the simple plan, the planned plan that works. This is the short and long term plan.

 

Forget about Atkins and South Beach and diet pills and dangerous meds or surgery. Forget about some diet fad that will make you sick, with artificial sweeteners and gluten and probably gelatin and “other ingredients” that give you IBS or central nervous system imbalance, like Aspartame does. Watch out for those weight watcher boxes of toxins too!! Danger Danger:

 


 


 


 

Forget about the No CARB thing, it doesn’t work. You can hurt your brain and body within 60 days on those. You can damage your memory too. Do some research on that, there is a lot out there.

 

Forget about starving yourself for a few days, it doesn’t work.

 

Forget about worrying about doing it right, because Mike Adams and Natural News keep it real, honest, researched and forthright. Look into this now, even if you just want to maintain the perfect weight and health, because maintenance is what it’s all about, not crazy dieting and then binging later.

 

Natural News actually helped expose two of the biggest ones in the last decade: the counterfeit hoodia scam, and the fake news acai weight loss scam.

Learn more: http://www.naturalnews.com/038968_weight_loss_supplements_fitness.html#ixzz2K3D0N2tS

 

Okay, so now you’ve dispelled the myths and you want the truth. How do you do this for now and for good? Here’s how:

 

LIQUID ALCHEMY: “The world's most potent serious weight management supplement. It's called Slimirexand it's a liquid combination of multiple plant extracts known for their beneficial effects on body weight.”

 


 

How does it work so well?

 Take the 10 question quiz and find out right now!
Learn more: http://www.naturalnews.com/038968_weight_loss_supplements_fitness.html#ixzz2K3DoX9hk

 

Product links:

 


 


 

 

 
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Monday, February 4, 2013

Big papers' Page 1 stories spotlight recovery center for pill addicts, lack of state program for problem gamblers

Gripping stories from recovering addicts, on the front pages of Kentucky's two largest newspapers this morning, highlight Kentuckians' fights against all types of addiction, from gambling to drugs.

Hope of recovery emerges from Laura Ungar's story in The Courier-Journal that focuses on the Isaiah House recovery center in Willisburg. A gymnasium at the site has been transformed into a factory of sorts, where a pill addict who has been clean three weeks polishes car parts, while a morphine addict with 103 days’ sobriety hammers nails into wood to make pallets, Ungar reports.

Work is an essential part of recovery at the Isaiah House, giving structure to chaotic lives, teaching job skills and building confidence. “It gives them a sense of purpose, of accomplishment,” Executive Director Mark LaPalme told Ungar. “They get their dignity back — that’s what work does.”

LaPalme, a Connecticut native and recovering cocaine addict, said he started Isaiah House in his basement in 1999, after a spiritual experience moved him to set aside seven bedrooms for other addicts. Today, the house helps to rebuild the lives of drug and alcohol addicts, while promoting worth ethic and responsibility throughout the recovery process (Read more).

Jack Brammer of the Lexington Herald-Leader writes about Kentucky's lack of a state program to treat problem gamblers. It is one of 13 states without such a program.

Billy Stephens, 66, Hawesville Mayor Rita Stephens' husband, said he lived a "a life of lies" with his gambling addiction, but with professional treatment, has not gambled since 2010. When he finally sought treatment, he could find no affordable treatment in Kentucky. The family had to borrow money to pay for his $6,000 treatment in a 36-day program in Louisiana, which is free to residents of the Bayou State.

"My addiction almost destroyed me," he told Brammer. "My insurance in Kentucky would have helped with my treatment if it were alcohol. But it was gambling." (Read more)
Gripping stories from recovering addicts, on the front pages of Kentucky's two largest newspapers this morning, highlight Kentuckians' fights against all types of addiction, from gambling to drugs.

Hope of recovery emerges from Laura Ungar's story in The Courier-Journal that focuses on the Isaiah House recovery center in Willisburg. A gymnasium at the site has been transformed into a factory of sorts, where a pill addict who has been clean three weeks polishes car parts, while a morphine addict with 103 days’ sobriety hammers nails into wood to make pallets, Ungar reports.

Work is an essential part of recovery at the Isaiah House, giving structure to chaotic lives, teaching job skills and building confidence. “It gives them a sense of purpose, of accomplishment,” Executive Director Mark LaPalme told Ungar. “They get their dignity back — that’s what work does.”

LaPalme, a Connecticut native and recovering cocaine addict, said he started Isaiah House in his basement in 1999, after a spiritual experience moved him to set aside seven bedrooms for other addicts. Today, the house helps to rebuild the lives of drug and alcohol addicts, while promoting worth ethic and responsibility throughout the recovery process (Read more).

Jack Brammer of the Lexington Herald-Leader writes about Kentucky's lack of a state program to treat problem gamblers. It is one of 13 states without such a program.

Billy Stephens, 66, Hawesville Mayor Rita Stephens' husband, said he lived a "a life of lies" with his gambling addiction, but with professional treatment, has not gambled since 2010. When he finally sought treatment, he could find no affordable treatment in Kentucky. The family had to borrow money to pay for his $6,000 treatment in a 36-day program in Louisiana, which is free to residents of the Bayou State.

"My addiction almost destroyed me," he told Brammer. "My insurance in Kentucky would have helped with my treatment if it were alcohol. But it was gambling." (Read more)
Read More


Report says veteran suicide rate is up from 2007

Almost every hour in this country, on average, a veteran commits suicide. The Department of Veterans Affairs reported that 22 veterans per day took their own lives in 2010, up four a day from the 2007 rate. Perhaps contrary to public perception, the report said most suicides occurred among veterans over 50. It recognized Vietnam-era veterans as a risk group, as well as female veterans.

Military service members come disproportionately from rural areas. Kentucky has two army posts, Fort Knox and Fort Campbell.

(Among active service members in 2012, more died from suicide than in combat, we reported here. The Army said Friday that 325 soldiers committed suicides last year; if the tentative number is confirmed, it would be a historical high. "If that bleak total remains at 325, the toll in 2012 would have risen by 15 percent over 2011 when the Army sustained 283 suicides," NBC News reported.)

Reactions to the VA report ranged from encouragement to outrage. The VA pointed out that the daily veteran suicide rate has "remained relatively stable over the past 12 years," but the percentage of the overall national suicide rate accounted for by veteran suicide has actually decreased.  Veteran suicides accounted for about one-fifth of American suicides in 2010, down from one-fourth of suicides in 1999.

The VA said that showed its programs are working, but promised to take "immediate actions." NBC reported that "the top strategy" on the VA's agenda was an already-established task force that could help suicide screening identify warning signs earlier.

Some groups were dismayed by the VA report and demanded more action. Iraq and Afghanistan Veterans of America called for more research and collaboration. "The country should be outraged that we are allowing this tragedy to continue," IAVA found and CEO Paul Rieckhoff told NBC.

On Feb. 13, the U.S. House Committee on Veterans' Affairs will hold a hearing on veterans and mental health care. The Veterans Crisis Line -- 800-273-TALK -- is available for veterans who are concerned about their mental health. (Read more)

Almost every hour in this country, on average, a veteran commits suicide. The Department of Veterans Affairs reported that 22 veterans per day took their own lives in 2010, up four a day from the 2007 rate. Perhaps contrary to public perception, the report said most suicides occurred among veterans over 50. It recognized Vietnam-era veterans as a risk group, as well as female veterans.

Military service members come disproportionately from rural areas. Kentucky has two army posts, Fort Knox and Fort Campbell.

(Among active service members in 2012, more died from suicide than in combat, we reported here. The Army said Friday that 325 soldiers committed suicides last year; if the tentative number is confirmed, it would be a historical high. "If that bleak total remains at 325, the toll in 2012 would have risen by 15 percent over 2011 when the Army sustained 283 suicides," NBC News reported.)

Reactions to the VA report ranged from encouragement to outrage. The VA pointed out that the daily veteran suicide rate has "remained relatively stable over the past 12 years," but the percentage of the overall national suicide rate accounted for by veteran suicide has actually decreased.  Veteran suicides accounted for about one-fifth of American suicides in 2010, down from one-fourth of suicides in 1999.

The VA said that showed its programs are working, but promised to take "immediate actions." NBC reported that "the top strategy" on the VA's agenda was an already-established task force that could help suicide screening identify warning signs earlier.

Some groups were dismayed by the VA report and demanded more action. Iraq and Afghanistan Veterans of America called for more research and collaboration. "The country should be outraged that we are allowing this tragedy to continue," IAVA found and CEO Paul Rieckhoff told NBC.

On Feb. 13, the U.S. House Committee on Veterans' Affairs will hold a hearing on veterans and mental health care. The Veterans Crisis Line -- 800-273-TALK -- is available for veterans who are concerned about their mental health. (Read more)

Read More


Invisible health panel could help Ky., if it had money and met

A panel charged with helping devise solutions to the nation’s health-care workforce crisis, which includes ensuring rural areas have enough health-care providers, is having a workforce crisis of its own: It hasn’t been funded, and it’s never met, writesKyle Cheney of Politico. 

The National Health Care Workforce Commission was created by Congress nearly three years ago under the Affordable Care Act, the panelists were appointed, but that’s about it. The lack of action was noted at a hearing Tuesday of a subcommittee of the Senate Special Committee on Aging, convened by Sen. Bernie Sanders (I-Vt.), chairman of the Subcommittee on Primary Health and Aging.

Sanders issued a report estimating that 57 million Americans lack ready access to primary care. Since  millions are expected to gain coverage when the reform law goes into full effect next year, there is a looming concern over whether there are enough doctors, physicians' assistants, nurse practitioners, nurses and so on. Most of the worry relates to the lack of primary-care providers in underserved areas, which could be a huge problem for Kentucky.

In addition to exploring the health workforce needs in rural and “medically underserved” settings, the commission was supposed to address the capacity of the nursing workforce, graduate medical education policies, education and loan programs for health-care professionals and the “mental and behavioral health care workforce capacity,” writes Cheney.

Since the 15-member panel was appointed in September 2010 by the U.S. comptroller general, 10 members’ terms have expired, and they’ve been reappointed for another three years each, Cheney reports. No funding has been approved, although both Senate Democrats and President Barack Obama have proposed $3 million funding packages.

“In order for the promise of expanded coverage passed into law by ACA to become a reality, the provisions designed to reach those goals must be fully funded and implemented,” Sanders said. “We need to make sure that our health care system has the infrastructure in place to provide the care necessary to prevent diseases and improve the health of all Americans.” (Read more)
A panel charged with helping devise solutions to the nation’s health-care workforce crisis, which includes ensuring rural areas have enough health-care providers, is having a workforce crisis of its own: It hasn’t been funded, and it’s never met, writesKyle Cheney of Politico. 

The National Health Care Workforce Commission was created by Congress nearly three years ago under the Affordable Care Act, the panelists were appointed, but that’s about it. The lack of action was noted at a hearing Tuesday of a subcommittee of the Senate Special Committee on Aging, convened by Sen. Bernie Sanders (I-Vt.), chairman of the Subcommittee on Primary Health and Aging.

Sanders issued a report estimating that 57 million Americans lack ready access to primary care. Since  millions are expected to gain coverage when the reform law goes into full effect next year, there is a looming concern over whether there are enough doctors, physicians' assistants, nurse practitioners, nurses and so on. Most of the worry relates to the lack of primary-care providers in underserved areas, which could be a huge problem for Kentucky.

In addition to exploring the health workforce needs in rural and “medically underserved” settings, the commission was supposed to address the capacity of the nursing workforce, graduate medical education policies, education and loan programs for health-care professionals and the “mental and behavioral health care workforce capacity,” writes Cheney.

Since the 15-member panel was appointed in September 2010 by the U.S. comptroller general, 10 members’ terms have expired, and they’ve been reappointed for another three years each, Cheney reports. No funding has been approved, although both Senate Democrats and President Barack Obama have proposed $3 million funding packages.

“In order for the promise of expanded coverage passed into law by ACA to become a reality, the provisions designed to reach those goals must be fully funded and implemented,” Sanders said. “We need to make sure that our health care system has the infrastructure in place to provide the care necessary to prevent diseases and improve the health of all Americans.” (Read more)
Read More


Stem cell treatment for feline asthma

Progress report: Winn grant MT11-002

Mesenchymal stem cells as a novel treatment for feline asthma: evaluation of efficacy and mechanisms of immunomodulation

Carol Reinero DVM, DACVIM, PhD and Amy DeClue DVM, DACVIM, MS; University of Missouri in collaboration with Colorado State University
 

Asthma is a common inflammatory lower airway disease affecting up to 5% of the pet cat population. Asthma is characterized by abnormal inflammatory cells in the lungs (eosinophils), airway constriction causing difficulty breathing, and permanent structural changes that lead to a decline in lung function. There has been recent interest in the ability of intravenous stem cell therapy to treat inflammatory diseases. One such area of study is lung disease, including asthma. In this Winn-funded study, the investigators sought to study the effects of intravenous mesenchymal stem cells (MSC) on the clinical signs and alterations in airway resistance/constriction in an experimental model of feline asthma.

Using Aerokat 2Nine cats with an established asthmatic state received 6 intravenous infusions of stem cells or a placebo infusion. To assess the effects of MSC infusion on decreasing airway inflammation, measurements were obtained at baseline, 3 days after the first infusion, and the final after all 6 infusions had been administered. Measurements were performed on a sample of fluid collected from the airways and the percentage of cells that were eosinophils determined. A visual analog scale (VAS) was used to evaluate the response to MSC on the clinical signs of asthma and a ventilator lung mechanics procedure performed to objectively measure the effects of MSC on airway resistance.

Improvements in the asthmatic state can be noted early or can be delayed several months after stem cell treatment. The initial data analysis has revealed that in the early stages after stem cell administration very few changes were noted compared with placebo treatment. Importantly, this does not mean MSCs failed to work; in fact, the investigators have data from an additional small pilot study that suggests that changes continue to become apparent months after stem cell infusion and these changes are marked in comparison with effects after early stem cell administration.

Because dramatic responses to stem cell therapy may occur months after administration, the investigators have applied for and received partial funding (recently funded MT 12-003) to continue evaluating the cats in this study for assessment of airway inflammation. With this newest funding and efforts to obtain additional funding, they can use advanced imaging techniques (CT scans), ventilator lung mechanics, and immunologic assays to help provide information regarding if and how stem cells could be an important and viable treatment option for pet cats suffering from this chronic lung disease. [VT]

Related blog articles:
Feline stem cells (May 2012)

More on cat health:
Winn Feline Foundation Library
Find us on Facebook
Follow us on Twitter
Join us on Google+
Progress report: Winn grant MT11-002

Mesenchymal stem cells as a novel treatment for feline asthma: evaluation of efficacy and mechanisms of immunomodulation

Carol Reinero DVM, DACVIM, PhD and Amy DeClue DVM, DACVIM, MS; University of Missouri in collaboration with Colorado State University
 

Asthma is a common inflammatory lower airway disease affecting up to 5% of the pet cat population. Asthma is characterized by abnormal inflammatory cells in the lungs (eosinophils), airway constriction causing difficulty breathing, and permanent structural changes that lead to a decline in lung function. There has been recent interest in the ability of intravenous stem cell therapy to treat inflammatory diseases. One such area of study is lung disease, including asthma. In this Winn-funded study, the investigators sought to study the effects of intravenous mesenchymal stem cells (MSC) on the clinical signs and alterations in airway resistance/constriction in an experimental model of feline asthma.

Using Aerokat 2Nine cats with an established asthmatic state received 6 intravenous infusions of stem cells or a placebo infusion. To assess the effects of MSC infusion on decreasing airway inflammation, measurements were obtained at baseline, 3 days after the first infusion, and the final after all 6 infusions had been administered. Measurements were performed on a sample of fluid collected from the airways and the percentage of cells that were eosinophils determined. A visual analog scale (VAS) was used to evaluate the response to MSC on the clinical signs of asthma and a ventilator lung mechanics procedure performed to objectively measure the effects of MSC on airway resistance.

Improvements in the asthmatic state can be noted early or can be delayed several months after stem cell treatment. The initial data analysis has revealed that in the early stages after stem cell administration very few changes were noted compared with placebo treatment. Importantly, this does not mean MSCs failed to work; in fact, the investigators have data from an additional small pilot study that suggests that changes continue to become apparent months after stem cell infusion and these changes are marked in comparison with effects after early stem cell administration.

Because dramatic responses to stem cell therapy may occur months after administration, the investigators have applied for and received partial funding (recently funded MT 12-003) to continue evaluating the cats in this study for assessment of airway inflammation. With this newest funding and efforts to obtain additional funding, they can use advanced imaging techniques (CT scans), ventilator lung mechanics, and immunologic assays to help provide information regarding if and how stem cells could be an important and viable treatment option for pet cats suffering from this chronic lung disease. [VT]

Related blog articles:
Feline stem cells (May 2012)

More on cat health:
Winn Feline Foundation Library
Find us on Facebook
Follow us on Twitter
Join us on Google+
Read More