Vitamin D: Possible cure for baldness?

Researchers investigating what causes hair follicles to go dormant are helping lead us toward a potential cure for baldness.

Current treatments for baldness prevent further hair loss but don’t actually increase hair growth. Several research teams are working to uncover ways to “wake up” existing dormant hair follicles. Scientists are finding that vitamin D and vitamin D receptors are crucial to continuing hair growth.

Typical hair growth follows a cycle. Hair follicles produce hair for two to six years before the hair falls out after which the follicles lie dormant for a short period. After a few weeks to a few months a new hair emerges. Sometimes the hair follicles permanently stay “asleep”, resulting in baldness.

Research so far has been encouraging. Dr Kotaro Yoshimura and colleagues at the University of Tokyo studied rats and found more stem cells became hair follicles when vitamin D was used in the final phase of growing the cells, when compared with those not treated with vitamin D. They also found that more of the follicles eventually produced hair, suggesting a potential role for vitamin D in hair transplants.

The key is the vitamin D receptor, not vitamin D alone. The receptor activates hair growth, so the next step will be to focus on activating the vitamin D receptor to possibly initiate hair growth.

Dr Yoshimura and colleagues are currently planning a clinical trial which will investigate new hair transplantation techniques involving their recent vitamin D research.

To read the full story click here.

Source:

The Wall Street Journal. The search for a baldness cure. September 2012.

About Dr Kevin Lau

Dr Kevin Lau DC is the founder of Health In Your Hands, a series of tools for Scoliosis prevention and treatment. The set includes his book Your Plan for Natural Scoliosis Prevention and Treatment, a companion Scoliosis Exercises for Prevention and Correction DVD and the innovative new iPhone application ScolioTrack. Dr Kevin Lau is a graduate in Doctor of Chiropractic from RMIT University in Melbourne Australia and Masters in Holistic Nutrition. He is a member of International Society On Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT), the leading international society on conservative treatment of spinal deformities. In 2006 I was awarded the "Best Health-care Provider Awards" by the largest Newspaper publication in Singapore on October 18 2006 as well as being interviewed on Primetime Channel News Asia as well as other TV and Radio. For more information on Dr Kevin Lau, watch his interviews or get a free sneak peek of his book, go to: http://www.hiyh.info.

Researchers investigating what causes hair follicles to go dormant are helping lead us toward a potential cure for baldness.

Current treatments for baldness prevent further hair loss but don’t actually increase hair growth. Several research teams are working to uncover ways to “wake up” existing dormant hair follicles. Scientists are finding that vitamin D and vitamin D receptors are crucial to continuing hair growth.

Typical hair growth follows a cycle. Hair follicles produce hair for two to six years before the hair falls out after which the follicles lie dormant for a short period. After a few weeks to a few months a new hair emerges. Sometimes the hair follicles permanently stay “asleep”, resulting in baldness.

Research so far has been encouraging. Dr Kotaro Yoshimura and colleagues at the University of Tokyo studied rats and found more stem cells became hair follicles when vitamin D was used in the final phase of growing the cells, when compared with those not treated with vitamin D. They also found that more of the follicles eventually produced hair, suggesting a potential role for vitamin D in hair transplants.

The key is the vitamin D receptor, not vitamin D alone. The receptor activates hair growth, so the next step will be to focus on activating the vitamin D receptor to possibly initiate hair growth.

Dr Yoshimura and colleagues are currently planning a clinical trial which will investigate new hair transplantation techniques involving their recent vitamin D research.

To read the full story click here.

Source:

The Wall Street Journal. The search for a baldness cure. September 2012.

About Dr Kevin Lau

Dr Kevin Lau DC is the founder of Health In Your Hands, a series of tools for Scoliosis prevention and treatment. The set includes his book Your Plan for Natural Scoliosis Prevention and Treatment, a companion Scoliosis Exercises for Prevention and Correction DVD and the innovative new iPhone application ScolioTrack. Dr Kevin Lau is a graduate in Doctor of Chiropractic from RMIT University in Melbourne Australia and Masters in Holistic Nutrition. He is a member of International Society On Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT), the leading international society on conservative treatment of spinal deformities. In 2006 I was awarded the "Best Health-care Provider Awards" by the largest Newspaper publication in Singapore on October 18 2006 as well as being interviewed on Primetime Channel News Asia as well as other TV and Radio. For more information on Dr Kevin Lau, watch his interviews or get a free sneak peek of his book, go to: http://www.hiyh.info.

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Walmart, Humana to give discount on healthier grocery choices like veggies, fruit, lean meat, skim milk, certain packaged goods

Starting Oct. 15, more than 1 million members of Humana Inc.'s Healthy Rewards program will start getting a 5 percent credit on about 1,300 healthy food items at all U.S. Walmart stores.  The credit can be used against future purchases at Walmart, which is the largest U.S. food retailer.

Walmart has taken note that "one of the biggest barriers to healthy nutrition is cost," Dr. John Agwunobi, president of health and wellness at Walmart, told Reuters. His company, he said, is trying an overall approach to improve the nutritional value of the food it sells. And because food accounts for more than half of Walmart's annual sales, and since it has tremendous clout in the U.S. market, the hope is that changes at its stores can influence other supermarket chains to do more about healthy eating.

Walmart products eligible for the credit include fresh fruits, vegetables, lean cuts of meat, skim milk, brown rice and packaged goods, the company told Reuters. The program works with a HumanaVitality card provided to members of Humana's rewards unit who receive points for meeting health goals. (Read more)

Starting Oct. 15, more than 1 million members of Humana Inc.'s Healthy Rewards program will start getting a 5 percent credit on about 1,300 healthy food items at all U.S. Walmart stores.  The credit can be used against future purchases at Walmart, which is the largest U.S. food retailer.

Walmart has taken note that "one of the biggest barriers to healthy nutrition is cost," Dr. John Agwunobi, president of health and wellness at Walmart, told Reuters. His company, he said, is trying an overall approach to improve the nutritional value of the food it sells. And because food accounts for more than half of Walmart's annual sales, and since it has tremendous clout in the U.S. market, the hope is that changes at its stores can influence other supermarket chains to do more about healthy eating.

Walmart products eligible for the credit include fresh fruits, vegetables, lean cuts of meat, skim milk, brown rice and packaged goods, the company told Reuters. The program works with a HumanaVitality card provided to members of Humana's rewards unit who receive points for meeting health goals. (Read more)

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18 Kentucky hospitals cited as 'top performers' on accreditation board's annual list

Eighteen Kentucky hospitals have been included on the annual list of hospitals that have excelled at adhering to basic procedures for surgery and other treatment of common illnesses such as heart attacks, heart failure and pneumonia. The Joint Commission, the nation’s major hospital accreditation board, has released this year's list of 620 hospitals considered to be “top performers” for following recommended protocols at least 95 percent of the time. The top 18 percent of accredited hospitals make the list.

Among the Kentucky hospitals that qualified on all four measurements were Greenview Hospital in Bowling Green, Ephraim McDowell Regional Medical Center in Danville, St. Elizabeth Medical Center in both Florence and Fort Thomas, Central Baptist Hospital in Lexington.

Those qualifying in three categories were the Robley Rex Veterans Affairs Medical Center in Louisville (not in surgery) and the Appalachian Regional Hospitals in Harlan and Middlesboro (not in heart attack).

Qualifying in two categories were Twin Lakes Regional Medical Center in Leitchfield, Frankfort Regional Medical Center, the Hospital of Louisa and Jackson Hospital Corp., all for pneumonia and surgical care.

Recognized for pneumonia care were Parkway Regional Hospital in Fulton, Paul B. Hall Regional Medical Center in Paintsville, Logan Memorial Hospital in Russellville and the KentuckyOne Health Hospital in Martin.

Among behavioral-health hospitals, ranked on their in-patient psychiatric care, the Kentucky facilities on the list were the Universal Health Services facility in Bowling Green, the new Cumberland Hall Hospital in Hopkinsville.

According to Kaiser Health News, the Leapfrog Group, a nonprofit organization devoted to patient safety, aided in the rankings process, as did Consumer Reports. The Commission has its own metrics. It's worth noting that next month, Medicare will start using hospital quality rankings on its Hospital Compare website to set reimbursements. (Read more)

Eighteen Kentucky hospitals have been included on the annual list of hospitals that have excelled at adhering to basic procedures for surgery and other treatment of common illnesses such as heart attacks, heart failure and pneumonia. The Joint Commission, the nation’s major hospital accreditation board, has released this year's list of 620 hospitals considered to be “top performers” for following recommended protocols at least 95 percent of the time. The top 18 percent of accredited hospitals make the list.

Among the Kentucky hospitals that qualified on all four measurements were Greenview Hospital in Bowling Green, Ephraim McDowell Regional Medical Center in Danville, St. Elizabeth Medical Center in both Florence and Fort Thomas, Central Baptist Hospital in Lexington.

Those qualifying in three categories were the Robley Rex Veterans Affairs Medical Center in Louisville (not in surgery) and the Appalachian Regional Hospitals in Harlan and Middlesboro (not in heart attack).

Qualifying in two categories were Twin Lakes Regional Medical Center in Leitchfield, Frankfort Regional Medical Center, the Hospital of Louisa and Jackson Hospital Corp., all for pneumonia and surgical care.

Recognized for pneumonia care were Parkway Regional Hospital in Fulton, Paul B. Hall Regional Medical Center in Paintsville, Logan Memorial Hospital in Russellville and the KentuckyOne Health Hospital in Martin.

Among behavioral-health hospitals, ranked on their in-patient psychiatric care, the Kentucky facilities on the list were the Universal Health Services facility in Bowling Green, the new Cumberland Hall Hospital in Hopkinsville.

According to Kaiser Health News, the Leapfrog Group, a nonprofit organization devoted to patient safety, aided in the rankings process, as did Consumer Reports. The Commission has its own metrics. It's worth noting that next month, Medicare will start using hospital quality rankings on its Hospital Compare website to set reimbursements. (Read more)

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After two days with doctors at work, Herald-Leader columnist wonders about patients and future of health-care system

Tom Eblen

Tom Eblen, the Lexington Herald-Leader's local columnist and former editor, spent two days shadowing doctors last week and lived to tell about it. Part of the Lexington Medical Society's Mini-Internship Program, Eblen was given a close-up look at the working lives of physicians and the world in which they, well, operate. He found himself alongside an orthopedic surgeon replacing shoulders, doing fascinating retinal work with an caring opthalmologist, in an emergency room on a slow day and with a busy internal medicine specialist. He learned more than confirming he had probably made the correct career choice, he writes.

In the emergency room: "A middle-aged man with a history of heart trouble came in with chest pains. An elderly man came in suffering from dizziness. A young man came in with an infection from a mouth full of rotten teeth. Like more than one-quarter of all Kentuckians, the young man and several other people Wooster saw that day had no health insurance. What people forget when they debate the cost of universal coverage is that society already pays for treating uninsured people, often at high-cost emergency rooms. . . .

"As I shadowed these physicians, I kept thinking how much of their patients' pain and suffering could have been avoided if they had taken better care of themselves — if they had eaten better, gotten more exercise, and avoided cigarettes and substance abuse. I wondered how we will continue to manage not only our health care system, but our rising expectations. As people live longer and get sicker, we may need to focus more on quality of life rather than simply extending it at all costs." (Read more)

Tom Eblen

Tom Eblen, the Lexington Herald-Leader's local columnist and former editor, spent two days shadowing doctors last week and lived to tell about it. Part of the Lexington Medical Society's Mini-Internship Program, Eblen was given a close-up look at the working lives of physicians and the world in which they, well, operate. He found himself alongside an orthopedic surgeon replacing shoulders, doing fascinating retinal work with an caring opthalmologist, in an emergency room on a slow day and with a busy internal medicine specialist. He learned more than confirming he had probably made the correct career choice, he writes.

In the emergency room: "A middle-aged man with a history of heart trouble came in with chest pains. An elderly man came in suffering from dizziness. A young man came in with an infection from a mouth full of rotten teeth. Like more than one-quarter of all Kentuckians, the young man and several other people Wooster saw that day had no health insurance. What people forget when they debate the cost of universal coverage is that society already pays for treating uninsured people, often at high-cost emergency rooms. . . .

"As I shadowed these physicians, I kept thinking how much of their patients' pain and suffering could have been avoided if they had taken better care of themselves — if they had eaten better, gotten more exercise, and avoided cigarettes and substance abuse. I wondered how we will continue to manage not only our health care system, but our rising expectations. As people live longer and get sicker, we may need to focus more on quality of life rather than simply extending it at all costs." (Read more)

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White children exposed to high levels of chemical BPA are five times more likely to be obese, study concludes

White children exposed to high levels of bisphenol A, better known as BPA, are five times more likely to be obese than children with low levels, according to a study published last week in the Journal of the American Medical Association. The study by the New York University School of Medicine is the first to link the chemical to obesity in children, which is especially prevalent in Kentucky.

Environment Health News reporter Brien Bienkowski reports that scientists found traces of BPA, which are used in some canned food and beverages, paper receipts and dental sealants, "are found in virtually every U.S. adult and child. In the study of body mass and BPA data from 2,838 youths aged 6 to 19, only white children were found to have significant increases in obesity prevalence as their BPA levels increased. Those with the highest concentrations in their urine were five times more likely to be obese than children with the lowest levels. Black children with higher BPA levels were 1.25 times more likely to be obese than those with lower levels, which the scientists said is not statistically significant. Hispanic children had the same rates of obesity at the highest and lowest levels."

Bienkowski reports that "representatives from the chemical industry said the study had too many weaknesses to prove any connection. Steven Hentges, from the American Chemistry Council's Polycarbonate/BPA Global Group, said that attempts 'to link our national obesity problem to minute exposures to chemicals found in common, everyday products are a distraction from the real efforts underway to address this important national health issue.' "

One study of preschoolers in North Carolina and Ohio found that 99 percent of BPA exposure was through food. But since the chemical is in many plastics and other products, this is difficult for scientists to pin down. “People are always told if you just stop eating or exercise more, you will lose weight. But there may be more to it … and I think there is,” said Retha Newbold, a visiting scientist at the National Institute of Environmental Health Sciences, who specializes in BPA and other endocrine-disrupting chemicals.  (Read more)

James Bruggers, environmental writer for The Courier-Journal, noted the report here.

White children exposed to high levels of bisphenol A, better known as BPA, are five times more likely to be obese than children with low levels, according to a study published last week in the Journal of the American Medical Association. The study by the New York University School of Medicine is the first to link the chemical to obesity in children, which is especially prevalent in Kentucky.

Environment Health News reporter Brien Bienkowski reports that scientists found traces of BPA, which are used in some canned food and beverages, paper receipts and dental sealants, "are found in virtually every U.S. adult and child. In the study of body mass and BPA data from 2,838 youths aged 6 to 19, only white children were found to have significant increases in obesity prevalence as their BPA levels increased. Those with the highest concentrations in their urine were five times more likely to be obese than children with the lowest levels. Black children with higher BPA levels were 1.25 times more likely to be obese than those with lower levels, which the scientists said is not statistically significant. Hispanic children had the same rates of obesity at the highest and lowest levels."

Bienkowski reports that "representatives from the chemical industry said the study had too many weaknesses to prove any connection. Steven Hentges, from the American Chemistry Council's Polycarbonate/BPA Global Group, said that attempts 'to link our national obesity problem to minute exposures to chemicals found in common, everyday products are a distraction from the real efforts underway to address this important national health issue.' "

One study of preschoolers in North Carolina and Ohio found that 99 percent of BPA exposure was through food. But since the chemical is in many plastics and other products, this is difficult for scientists to pin down. “People are always told if you just stop eating or exercise more, you will lose weight. But there may be more to it … and I think there is,” said Retha Newbold, a visiting scientist at the National Institute of Environmental Health Sciences, who specializes in BPA and other endocrine-disrupting chemicals.  (Read more)

James Bruggers, environmental writer for The Courier-Journal, noted the report here.

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Lexington lawyer writes booklet helping Kentucky businesses to break down health-care reform law

Margaret Levi, a lawyer with the Lexington firm of Wyatt, Tarrant & Combs, has authored a new publication, The Impact of Health Care Reform on Kentucky Employers. The 68-page booklet, published by the Kentucky Chamber of Commerce, is a readable summary of The Patient Protection and Affordable Care Act, writes Greg Kocher of the Lexington Herald-Leader.

The law that started taking effect in March 2010 has had more more interpretations and critics than it has pages -- that's 2,555, if you don't count the legal citation references that require reading included within it. "There's a lot of criticism of it from people who haven't read it, and I think you have to know it before you can criticize it," said Levi, a Danville native and resident, said of the law. "I'm not taking a political position one way or another. I am neutral and I tried very hard to remain neutral."

The most common misconception about the law "is that all health care is going to be free and people can get all the care they want," Levi told Kocher. 'So there are some unrealistic expectations on behalf of consumers."

Levi also noted some confusion about how different-sized businesses qualify for different exemptions under different provisions of the law.  She said that some employers are weighing the "pay or play" mandate that takes effect in 2014. Under that provision, writes Kocher, "employers with 50 or more employees must provide 'minimum essential' health plan coverage to their eligible employees or pay a penalty if an eligible employee obtains coverage through a state-sponsored health insurance exchange and qualifies for benefits subsidized by the government. An employer who offers no health coverage will be subject to a penalty equal to $2,000 a year per employee after the first 30 employees. "I think some employers are doing the math as to whether they pay the penalty or provide insurance for their employees," Levis said. "I saw a report that said 88 percent of employers are still going to provide the coverage."

Jim Ford, vice president of business education for the Kentucky Chamber, told Kocher that the booklet "basically says here are the rules, here's what it means, here's what implementation means. We're leaving politics at the door. Here's what you need to know." (Read more) For information on buying the booklet, go here.

Margaret Levi, a lawyer with the Lexington firm of Wyatt, Tarrant & Combs, has authored a new publication, The Impact of Health Care Reform on Kentucky Employers. The 68-page booklet, published by the Kentucky Chamber of Commerce, is a readable summary of The Patient Protection and Affordable Care Act, writes Greg Kocher of the Lexington Herald-Leader.

The law that started taking effect in March 2010 has had more more interpretations and critics than it has pages -- that's 2,555, if you don't count the legal citation references that require reading included within it. "There's a lot of criticism of it from people who haven't read it, and I think you have to know it before you can criticize it," said Levi, a Danville native and resident, said of the law. "I'm not taking a political position one way or another. I am neutral and I tried very hard to remain neutral."

The most common misconception about the law "is that all health care is going to be free and people can get all the care they want," Levi told Kocher. 'So there are some unrealistic expectations on behalf of consumers."

Levi also noted some confusion about how different-sized businesses qualify for different exemptions under different provisions of the law.  She said that some employers are weighing the "pay or play" mandate that takes effect in 2014. Under that provision, writes Kocher, "employers with 50 or more employees must provide 'minimum essential' health plan coverage to their eligible employees or pay a penalty if an eligible employee obtains coverage through a state-sponsored health insurance exchange and qualifies for benefits subsidized by the government. An employer who offers no health coverage will be subject to a penalty equal to $2,000 a year per employee after the first 30 employees. "I think some employers are doing the math as to whether they pay the penalty or provide insurance for their employees," Levis said. "I saw a report that said 88 percent of employers are still going to provide the coverage."

Jim Ford, vice president of business education for the Kentucky Chamber, told Kocher that the booklet "basically says here are the rules, here's what it means, here's what implementation means. We're leaving politics at the door. Here's what you need to know." (Read more) For information on buying the booklet, go here.

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New approaches to treatment of feline diabetes mellitus

Final report, Winn grant W09-015
The incretin effect: A potential role for GLP-1 analogues in the treatment of feline diabetes?
Investigators: Chen Gilor, Thomas Graves; University of Illinois at Urbana-Champaign
 
A compelling animal model for diabetes is the cat because cats develop a spontaneous form of diabetes that closely resembles human type 2 diabetes. Incretin hormones are secreted from the intestines in response to specific nutrients. They potentiate insulin secretion and offer beneficial effects of glucose homeostasis. Two incretin hormones, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide 1 (GLP-1), account for the incretin effect in humans. One goal of this study was to determine whether the incretin effect occurs in cats by comparing the effect of oral glucose, lipids, or amino acids on serum concentrations of insulin, GIP, and GLP-1 in 10 healthy cats. The results indicated that the incretin effect does exist in cats but the effect on glucose-dependent insulin secretion is not as substantial as it is in people. They also noted that this potentiated effect is mediated by GLP-1 but not GLP. This lack of GIP response and a weak incretin effect could make the cat relatively glucose intolerant and might lead to inappropriate glycemic control in cats fed a diet high in carbohydrates.
 
Exenatide is a GLP-1 mimetic drug that has a glucose-dependent insulinotropic effect. In people with type 2 diabetes, exenatide is effective in controlling blood glucose with minimal side effects. The other goal of this study was to evaluate the effect of exenatide on insulin secretion during euglycemia and hyperglycemia in 9 young, healthy cats. The results indicate that exenatide in cats does stimulate glucose-dependent insulin secretion that is similar to the effect of exenatide in people. Further evaluation of the results did not show improved glucose tolerance with exenatide because its duration of effect was too short. The investigators feel that GLP-1-based medications have potential in treatment of diabetes in cats. Though exenatide will most likely not be clinically useful in cats, other drugs with a similar mechanism of action but longer duration of effect may be helpful. Such drugs would likely promote insulin secretion but may be safer than insulin injections because of the reduced likelihood of hypoglycemia. [VT]
 
Gilor, C., T. K. Graves, et al. (2011). The GLP-1 mimetic exenatide potentiates insulin secretion in healthy cats. Domest Anim Endocrinol 41(1): 42-49.

Gilor, C., T. K. Graves, et al. (2011). The incretin effect in cats: comparison between oral glucose, lipids, and amino acids. Domest Anim Endocrinol 40(4): 205-212.

More on cat health:
Winn Feline Foundation Library
Find us on Facebook
Follow us on Twitter
Join us on Google+

 

Final report, Winn grant W09-015
The incretin effect: A potential role for GLP-1 analogues in the treatment of feline diabetes?
Investigators: Chen Gilor, Thomas Graves; University of Illinois at Urbana-Champaign
 
A compelling animal model for diabetes is the cat because cats develop a spontaneous form of diabetes that closely resembles human type 2 diabetes. Incretin hormones are secreted from the intestines in response to specific nutrients. They potentiate insulin secretion and offer beneficial effects of glucose homeostasis. Two incretin hormones, glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide 1 (GLP-1), account for the incretin effect in humans. One goal of this study was to determine whether the incretin effect occurs in cats by comparing the effect of oral glucose, lipids, or amino acids on serum concentrations of insulin, GIP, and GLP-1 in 10 healthy cats. The results indicated that the incretin effect does exist in cats but the effect on glucose-dependent insulin secretion is not as substantial as it is in people. They also noted that this potentiated effect is mediated by GLP-1 but not GLP. This lack of GIP response and a weak incretin effect could make the cat relatively glucose intolerant and might lead to inappropriate glycemic control in cats fed a diet high in carbohydrates.
 
Exenatide is a GLP-1 mimetic drug that has a glucose-dependent insulinotropic effect. In people with type 2 diabetes, exenatide is effective in controlling blood glucose with minimal side effects. The other goal of this study was to evaluate the effect of exenatide on insulin secretion during euglycemia and hyperglycemia in 9 young, healthy cats. The results indicate that exenatide in cats does stimulate glucose-dependent insulin secretion that is similar to the effect of exenatide in people. Further evaluation of the results did not show improved glucose tolerance with exenatide because its duration of effect was too short. The investigators feel that GLP-1-based medications have potential in treatment of diabetes in cats. Though exenatide will most likely not be clinically useful in cats, other drugs with a similar mechanism of action but longer duration of effect may be helpful. Such drugs would likely promote insulin secretion but may be safer than insulin injections because of the reduced likelihood of hypoglycemia. [VT]
 
Gilor, C., T. K. Graves, et al. (2011). The GLP-1 mimetic exenatide potentiates insulin secretion in healthy cats. Domest Anim Endocrinol 41(1): 42-49.

Gilor, C., T. K. Graves, et al. (2011). The incretin effect in cats: comparison between oral glucose, lipids, and amino acids. Domest Anim Endocrinol 40(4): 205-212.

More on cat health:
Winn Feline Foundation Library
Find us on Facebook
Follow us on Twitter
Join us on Google+

 

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