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Wednesday, October 26, 2011

Scoliosis Surgery - The Untold Truth

My goal in the upcoming posts is to express and reveal several unspoken facts of scoliosis surgery. This information is delivered to you for educational purposes, knowledge building and choosing an informed scoliosis treatment.

Many scoliosis surgical decisions are made under high pressure from the treating physician, usually because of the rapidly increasing scoliosis curves. Scoliosis surgery procedures should be thoroughly researched, all possible complications understood, with possible alternative treatments reviewed.

This decision may, and can take up to two weeks, barring any traumatic emergencies. Scoliosis curve condition will not change greatly in two weeks. (Remember the wait and see time prior to the magical curve number for scoliosis surgery). An improperly chosen path of scoliosis treatment can become very painful once a person moves beyond their 21st birthday.

Scoliosis corrective surgeries, especially in repeat surgery cases, may damage the body’s sympathetic nervous system. This could produce subsequent loss of function, such as adjusting of one’s heart rate, blood flow, and body temperature regulating during activities.

A percentage scoliosis corrective surgeries may cause intolerable pain and functional difficulties in patients as early as their mid- 20s or 30s. The most severe scoliosis cases require theses patients to be placed on Social Security Disability.

Many times the pain level escalates very quickly after the growth hormone is reduced as a scoliosis person’s moves into their young adult years. This leads into anti-inflammatory, muscle relaxants, anti-depressants, and pain killers.

Bowel and bladder failure may occur if the spinal nerves near the lower lumbar area are damaged during scoliosis correction surgery.

A little known fact that is not discussed at length prior to one’s scoliosis surgery …

Once a scoliosis patient that has undergone scoliosis corrective surgery or spinal fusion, one can never “Go Back” and reverse the process to regain a functional spine.

Think on this…

In 99% of the scoliosis surgeries the joints of the vertebral bodies are surgically removed. They are known as the “Facets”.

Boney architecture removed in scoliosis surgery from the vertebral body is called the “Spinous Process”. This small area of vertebral body is where several muscle groups attach to create body/spinal movement.

You may be wondering, "How do I move this part of my body?"

This is not to be taken as a 3 dimensional model. The spine of a scoliosis person has scores of various changes at the microscopic and macroscopic levels.

Scoliosis is a very complex disease and one should not just take the action of “wait and see” if the scoliosis curve gets worse.

Scoliosis spinal fusion sometimes fails. The cause is due to instrument failure, bone breakage, or intolerable pain.

The fix for broken instruments, bone breakage and horrible pain?

I will strive to make the physics of a fused scoliosis spine simple.

As you may know the scoliosis fusion is 3 to 8 different vertebral bodies cemented together (by bone grafts) and held in place by rods, wires and or screws.

Approximately 6 months to 2 years later the bone heals into a solid column. This scoliosis column leans away from the center of gravity. Pressure is placed at both ends of the column and in the middle.

To understand these actions, take a paper clip and straighten it. As you may experience, it’s hard to get that wire straight, there are usually little curves left in it.

Now place both ends of the semi-straightened paper clip in between your index finger and thumb. Now slowly press your two fingers together.

In this demonstration, your index finger represents your head pushing downward; and your thumb represents your hip/pelvis pushing upward like the supporting of your torso. You should see the paper clip bending into a “C” shape.

Again the goal of this series of writings is to inform you of the realisms of scoliosis surgery and possible untold problems. A well informed person could experience reduced fear and worry surrounding scoliosis decisions.

As learned in the previous writings, the scoliosis curve will progress 1 to 3 degrees per year after one has surgery.

Why?.....

Well in your newly learned data base, the disease of scoliosis is not addressed by surgery; the scoliosis spine is just fused.

Now with the fused scoliosis curves, mechanics straighten by only 20% to 40 %( still a crooked column), this semi corrected curve fusion creates a long lever arm. This lever arm is not straight up and down with the force of gravity, and the forces pull out and downward on the scoliosis spine.

Scoliosis correction surgery is really spinal fusion.

The scoliosis patient is lead to believe that scoliosis surgery corrects the spinal deformity thereby correcting the disease of scoliosis; and that once the surgery scars heal, the disease is terminated.

Sorry to say, the scoliosis surgery procedure cannot, destroy, kill, eradicate, eliminate, and or stop the disease of scoliosis. I am not the first person to say this.

Did you know scoliosis surgical correction (scoliosis spinal fusion) can remove the adolescent from school for 2 to 3 months?

Are you aware that a full time sitter is needed to care for the child after surgery?

Assistance will be needed in the following areas: eating (simple thing as cutting their meat), bathing, going to the bathroom, dressing, studies, game playing, walking, administering medications, and most of all TLC.

The adult may be removed from work for a period of 6 to 12 months, with all of the above care as needed above.

Years after scoliosis surgical correction (scoliosis spinal fusion), the surgical fusion may result in one or more pseudoarthroses (cracks in segments of the fusion that never healed properly or broke with activity or age) often requiring additional scoliosis surgery.

Did you know that scoliosis corrective surgery, really… (scoliosis spinal fusion) can result in large blood loss?

The corrective scoliosis surgery often requiring the scoliosis patient to donate 3 to 6 pints of their blood prior to the operation. The patient may require additional blood from blood banks, thus exposing the scoliosis patient to blood-borne illness.

Did you know that it takes 6 to 12 months in adolescents’ scoliosis and 1 to 2 years in adults’ scoliosis for the bone of the fusion to totally heal? During this time the scoliosis patient may have to take medication for pain relief, wearing a brace, and limit their motion (no bending, lifting and restricted daily activities).

Scoliosis corrective surgery (scoliosis spinal fusion) costs huge sums of money. Charges for a posterior fusion may range upwards from $50,000, with additional surgical complication, the cost may rise an additional $50,000., total sums may range in the $100,000 area.

The anterior/posterior scoliosis surgery (scoliosis spinal fusion) that fuses 8 or more vertebral bodies will cost as much as $300,000.

What happens when the insurance company rejects partial or the total scoliosis insurance claim? What happens when the rod and or screws break six months to a year later?

Scoliosis spinal fusion surgeries are extremely invasive, especially the
fusion of the front vertebral body and then the posterior vertebral body, often
requiring two 15”to 20” incision front and back area. And yes, the incisions are
made in two different days.

During this type of scoliosis surgical procedure the internal organs are
removed from the chest cavity. This is often shifts and disturbs almost all
internal organs.

The lungs are the most venerable, which often need chest tubes following
surgery.

Anterior/posterior scoliosis spinal fusion surgeries are recognized as the
more invasive as any “elective” surgeries, including heart transplant.

Recovery times from this scoliosis surgery are extensive, difficult, and
emotionally challenging. The body’s hormones totally become reversed, which in
turn creates additional complications while healing.

In some of these cases, adaptive training is given to re-orient the brain to
the “new” body position. WOW!! One would thinks this could be done before
surgery, but this may expose some of the challenges scoliosis surgery.

Did you know, during your scoliosis surgery that bone tissues are taken from your hip?

Yes this is called autologous bone grafts. Bone tissue is laid in-between the posterior spinal vertebra as to promote bone fusion (a cementing affect).

During scoliosis surgery an incision is made along your hip (Iliac crest area), it’s proximally 3” to 5” long.

Some scoliosis patients that have undergone this scoliosis procedure say that the pain is worse than the long excision of the back area. To understand this comment, the scoliosis fusion does not move, but the hips are in constant movement, walking, setting, standing and of course working. This surgical site often leads to future pain and suffering.

Along with removing the bone tissue, the muscle attachments of the hip area are cut. Yes …again creating another biomechanical challenge for which the scoliosis body has to overcome. Some scoliosis surgeons may use the floating rib as autologous bone grafts. The scar is left around the mid waist. Yes, again you guessed it, the pain occurs while breathing, no chance of getting around the pain here.

Learning the different facts about scoliosis surgery may just become somewhat shocking to you. Again the goal of this series of writings is to inform you of the realisms of scoliosis surgery and possible untold problems. A well informed person could experience reduced fear and worry surrounding scoliosis decisions.

Scoliosis spinal fusion surgery still cannot correct all of the 3-D deformities of scoliosis. There is no perfectly straight spine after scoliosis spinal fusion surgery. The curves are still present, still twisted, just reduced and fused.

The ribs are not corrected in surgery, they remain untouched, asymmetrical shaped, meaning the rib hump is still present.

Unlevel hips and shoulders are present post scoliosis surgery. Some shoulder correction is seen, but unlikely straight and or level.
By Maggie Victoria

About Dr Kevin Lau
Dr Kevin Lau DC is the founder of Health In Your Hands, a series of tools for Scoliosis prevention and treatment. The set includes his book Your Plan for Natural Scoliosis Prevention and Treatment, a companion Scoliosis Exercises for Prevention and Correction DVD and the innovative new iPhone application ScolioTrack. Dr Kevin Lau D.C. is a graduate in Doctor of Chiropractic from RMIT University in Melbourne Australia and Masters in Holistic Nutrition from Clayton College of Natural Health in USA. In 2006 I was awarded the "Best Health-care Provider Awards" by the largest Newspaper publication in Singapore on October 18 2006 as well as being interviewed on Primetime Channel News Asia as well as other TV and Radio. For more information on Dr Kevin Lau, watch his interviews or get a free sneak peek of his book, go to: http://www.hiyh.info.
My goal in the upcoming posts is to express and reveal several unspoken facts of scoliosis surgery. This information is delivered to you for educational purposes, knowledge building and choosing an informed scoliosis treatment.

Many scoliosis surgical decisions are made under high pressure from the treating physician, usually because of the rapidly increasing scoliosis curves. Scoliosis surgery procedures should be thoroughly researched, all possible complications understood, with possible alternative treatments reviewed.

This decision may, and can take up to two weeks, barring any traumatic emergencies. Scoliosis curve condition will not change greatly in two weeks. (Remember the wait and see time prior to the magical curve number for scoliosis surgery). An improperly chosen path of scoliosis treatment can become very painful once a person moves beyond their 21st birthday.

Scoliosis corrective surgeries, especially in repeat surgery cases, may damage the body’s sympathetic nervous system. This could produce subsequent loss of function, such as adjusting of one’s heart rate, blood flow, and body temperature regulating during activities.

A percentage scoliosis corrective surgeries may cause intolerable pain and functional difficulties in patients as early as their mid- 20s or 30s. The most severe scoliosis cases require theses patients to be placed on Social Security Disability.

Many times the pain level escalates very quickly after the growth hormone is reduced as a scoliosis person’s moves into their young adult years. This leads into anti-inflammatory, muscle relaxants, anti-depressants, and pain killers.

Bowel and bladder failure may occur if the spinal nerves near the lower lumbar area are damaged during scoliosis correction surgery.

A little known fact that is not discussed at length prior to one’s scoliosis surgery …

Once a scoliosis patient that has undergone scoliosis corrective surgery or spinal fusion, one can never “Go Back” and reverse the process to regain a functional spine.

Think on this…

In 99% of the scoliosis surgeries the joints of the vertebral bodies are surgically removed. They are known as the “Facets”.

Boney architecture removed in scoliosis surgery from the vertebral body is called the “Spinous Process”. This small area of vertebral body is where several muscle groups attach to create body/spinal movement.

You may be wondering, "How do I move this part of my body?"

This is not to be taken as a 3 dimensional model. The spine of a scoliosis person has scores of various changes at the microscopic and macroscopic levels.

Scoliosis is a very complex disease and one should not just take the action of “wait and see” if the scoliosis curve gets worse.

Scoliosis spinal fusion sometimes fails. The cause is due to instrument failure, bone breakage, or intolerable pain.

The fix for broken instruments, bone breakage and horrible pain?

I will strive to make the physics of a fused scoliosis spine simple.

As you may know the scoliosis fusion is 3 to 8 different vertebral bodies cemented together (by bone grafts) and held in place by rods, wires and or screws.

Approximately 6 months to 2 years later the bone heals into a solid column. This scoliosis column leans away from the center of gravity. Pressure is placed at both ends of the column and in the middle.

To understand these actions, take a paper clip and straighten it. As you may experience, it’s hard to get that wire straight, there are usually little curves left in it.

Now place both ends of the semi-straightened paper clip in between your index finger and thumb. Now slowly press your two fingers together.

In this demonstration, your index finger represents your head pushing downward; and your thumb represents your hip/pelvis pushing upward like the supporting of your torso. You should see the paper clip bending into a “C” shape.

Again the goal of this series of writings is to inform you of the realisms of scoliosis surgery and possible untold problems. A well informed person could experience reduced fear and worry surrounding scoliosis decisions.

As learned in the previous writings, the scoliosis curve will progress 1 to 3 degrees per year after one has surgery.

Why?.....

Well in your newly learned data base, the disease of scoliosis is not addressed by surgery; the scoliosis spine is just fused.

Now with the fused scoliosis curves, mechanics straighten by only 20% to 40 %( still a crooked column), this semi corrected curve fusion creates a long lever arm. This lever arm is not straight up and down with the force of gravity, and the forces pull out and downward on the scoliosis spine.

Scoliosis correction surgery is really spinal fusion.

The scoliosis patient is lead to believe that scoliosis surgery corrects the spinal deformity thereby correcting the disease of scoliosis; and that once the surgery scars heal, the disease is terminated.

Sorry to say, the scoliosis surgery procedure cannot, destroy, kill, eradicate, eliminate, and or stop the disease of scoliosis. I am not the first person to say this.

Did you know scoliosis surgical correction (scoliosis spinal fusion) can remove the adolescent from school for 2 to 3 months?

Are you aware that a full time sitter is needed to care for the child after surgery?

Assistance will be needed in the following areas: eating (simple thing as cutting their meat), bathing, going to the bathroom, dressing, studies, game playing, walking, administering medications, and most of all TLC.

The adult may be removed from work for a period of 6 to 12 months, with all of the above care as needed above.

Years after scoliosis surgical correction (scoliosis spinal fusion), the surgical fusion may result in one or more pseudoarthroses (cracks in segments of the fusion that never healed properly or broke with activity or age) often requiring additional scoliosis surgery.

Did you know that scoliosis corrective surgery, really… (scoliosis spinal fusion) can result in large blood loss?

The corrective scoliosis surgery often requiring the scoliosis patient to donate 3 to 6 pints of their blood prior to the operation. The patient may require additional blood from blood banks, thus exposing the scoliosis patient to blood-borne illness.

Did you know that it takes 6 to 12 months in adolescents’ scoliosis and 1 to 2 years in adults’ scoliosis for the bone of the fusion to totally heal? During this time the scoliosis patient may have to take medication for pain relief, wearing a brace, and limit their motion (no bending, lifting and restricted daily activities).

Scoliosis corrective surgery (scoliosis spinal fusion) costs huge sums of money. Charges for a posterior fusion may range upwards from $50,000, with additional surgical complication, the cost may rise an additional $50,000., total sums may range in the $100,000 area.

The anterior/posterior scoliosis surgery (scoliosis spinal fusion) that fuses 8 or more vertebral bodies will cost as much as $300,000.

What happens when the insurance company rejects partial or the total scoliosis insurance claim? What happens when the rod and or screws break six months to a year later?

Scoliosis spinal fusion surgeries are extremely invasive, especially the
fusion of the front vertebral body and then the posterior vertebral body, often
requiring two 15”to 20” incision front and back area. And yes, the incisions are
made in two different days.

During this type of scoliosis surgical procedure the internal organs are
removed from the chest cavity. This is often shifts and disturbs almost all
internal organs.

The lungs are the most venerable, which often need chest tubes following
surgery.

Anterior/posterior scoliosis spinal fusion surgeries are recognized as the
more invasive as any “elective” surgeries, including heart transplant.

Recovery times from this scoliosis surgery are extensive, difficult, and
emotionally challenging. The body’s hormones totally become reversed, which in
turn creates additional complications while healing.

In some of these cases, adaptive training is given to re-orient the brain to
the “new” body position. WOW!! One would thinks this could be done before
surgery, but this may expose some of the challenges scoliosis surgery.

Did you know, during your scoliosis surgery that bone tissues are taken from your hip?

Yes this is called autologous bone grafts. Bone tissue is laid in-between the posterior spinal vertebra as to promote bone fusion (a cementing affect).

During scoliosis surgery an incision is made along your hip (Iliac crest area), it’s proximally 3” to 5” long.

Some scoliosis patients that have undergone this scoliosis procedure say that the pain is worse than the long excision of the back area. To understand this comment, the scoliosis fusion does not move, but the hips are in constant movement, walking, setting, standing and of course working. This surgical site often leads to future pain and suffering.

Along with removing the bone tissue, the muscle attachments of the hip area are cut. Yes …again creating another biomechanical challenge for which the scoliosis body has to overcome. Some scoliosis surgeons may use the floating rib as autologous bone grafts. The scar is left around the mid waist. Yes, again you guessed it, the pain occurs while breathing, no chance of getting around the pain here.

Learning the different facts about scoliosis surgery may just become somewhat shocking to you. Again the goal of this series of writings is to inform you of the realisms of scoliosis surgery and possible untold problems. A well informed person could experience reduced fear and worry surrounding scoliosis decisions.

Scoliosis spinal fusion surgery still cannot correct all of the 3-D deformities of scoliosis. There is no perfectly straight spine after scoliosis spinal fusion surgery. The curves are still present, still twisted, just reduced and fused.

The ribs are not corrected in surgery, they remain untouched, asymmetrical shaped, meaning the rib hump is still present.

Unlevel hips and shoulders are present post scoliosis surgery. Some shoulder correction is seen, but unlikely straight and or level.
By Maggie Victoria

About Dr Kevin Lau
Dr Kevin Lau DC is the founder of Health In Your Hands, a series of tools for Scoliosis prevention and treatment. The set includes his book Your Plan for Natural Scoliosis Prevention and Treatment, a companion Scoliosis Exercises for Prevention and Correction DVD and the innovative new iPhone application ScolioTrack. Dr Kevin Lau D.C. is a graduate in Doctor of Chiropractic from RMIT University in Melbourne Australia and Masters in Holistic Nutrition from Clayton College of Natural Health in USA. In 2006 I was awarded the "Best Health-care Provider Awards" by the largest Newspaper publication in Singapore on October 18 2006 as well as being interviewed on Primetime Channel News Asia as well as other TV and Radio. For more information on Dr Kevin Lau, watch his interviews or get a free sneak peek of his book, go to: http://www.hiyh.info.
Read More


Surgical Device Company Failed to Report Its Spinal Implant Causes Cancer


Surgical device company Medtronic paid surgeons millions of dollars to investigate the safety of their spinal implant products. Turns out they cause cancer, but no one reported it.
So the Milwaukee Journal-Sentinel did! They tell the disturbing story in an exhaustive investigative article. The devices in question, called Infuse and Amplify, are used in spinal fusion surgery. Surgeons wedge the devices between vertebrae to correct back irregularities including scoliosis, kyphosis, disc herniation, vertebral fracture and many others. Before the Medtronic devices, patients had to undergo an extra surgery to get replacement bone from their hip or they received donor bone. Infuse and Amplify eliminate that requirement with bone-growth-stimulating proteins. Revenue from Infuse has been about $700 million annually since coming on the market in 2002 (The FDA has declined approval of Amplify, and Medtronic is contesting the decision).
The author of the Journal-Sentinel article, John Fauber, recruited a physician researcher and sifted through 1,000 pages of FDA documents for his investigation to find that the bone-growth protein, called bone morphogenetic protein-2, is not as safe as Medtronic led folks to believe. Even though the surgeons claimed in a 2009 paper there was no significant link between the product and cancer, there totally was.
Failure to report the cancer could easily be attributed to a conflict of interest: For research that led to the 2009 paper, Medtronic paid investigators more than $10 million dollars to study Amplify's safety and effectiveness.
The 2009 paper on the trial was written by six physician authors. The first three authors of the paper - or entities they are associated with - received about $10 million from Medtronic, mostly in royalties, in 2010 alone. The royalties were for other products, not for BMP-2.
Two of the other authors received no compensation from Medtronic in 2010. Another author received between $5,000 and $9,999 for advisory services to the company.
It's bad news for Medtronic, which produces a variety of medical devices including pacemakers, implantable gadgets that thwart seizures, and many other gizmos for facilitating surgery. But it's way worse news for spine patients.


About Dr Kevin Lau
Dr Kevin Lau DC is the founder of Health In Your Hands, a series of tools for Scoliosis prevention and treatment. The set includes his book Your Plan for Natural Scoliosis Prevention and Treatment, a companion Scoliosis Exercises for Prevention and Correction DVD and the innovative new iPhone application ScolioTrack. Dr Kevin Lau D.C. is a graduate in Doctor of Chiropractic from RMIT University in Melbourne Australia and Masters in Holistic Nutrition from Clayton College of Natural Health in USA. In 2006 I was awarded the "Best Health-care Provider Awards" by the largest Newspaper publication in Singapore on October 18 2006 as well as being interviewed on Primetime Channel News Asia as well as other TV and Radio. For more information on Dr Kevin Lau, watch his interviews or get a free sneak peek of his book, go to: http://www.hiyh.info.

Surgical device company Medtronic paid surgeons millions of dollars to investigate the safety of their spinal implant products. Turns out they cause cancer, but no one reported it.
So the Milwaukee Journal-Sentinel did! They tell the disturbing story in an exhaustive investigative article. The devices in question, called Infuse and Amplify, are used in spinal fusion surgery. Surgeons wedge the devices between vertebrae to correct back irregularities including scoliosis, kyphosis, disc herniation, vertebral fracture and many others. Before the Medtronic devices, patients had to undergo an extra surgery to get replacement bone from their hip or they received donor bone. Infuse and Amplify eliminate that requirement with bone-growth-stimulating proteins. Revenue from Infuse has been about $700 million annually since coming on the market in 2002 (The FDA has declined approval of Amplify, and Medtronic is contesting the decision).
The author of the Journal-Sentinel article, John Fauber, recruited a physician researcher and sifted through 1,000 pages of FDA documents for his investigation to find that the bone-growth protein, called bone morphogenetic protein-2, is not as safe as Medtronic led folks to believe. Even though the surgeons claimed in a 2009 paper there was no significant link between the product and cancer, there totally was.
Failure to report the cancer could easily be attributed to a conflict of interest: For research that led to the 2009 paper, Medtronic paid investigators more than $10 million dollars to study Amplify's safety and effectiveness.
The 2009 paper on the trial was written by six physician authors. The first three authors of the paper - or entities they are associated with - received about $10 million from Medtronic, mostly in royalties, in 2010 alone. The royalties were for other products, not for BMP-2.
Two of the other authors received no compensation from Medtronic in 2010. Another author received between $5,000 and $9,999 for advisory services to the company.
It's bad news for Medtronic, which produces a variety of medical devices including pacemakers, implantable gadgets that thwart seizures, and many other gizmos for facilitating surgery. But it's way worse news for spine patients.


About Dr Kevin Lau
Dr Kevin Lau DC is the founder of Health In Your Hands, a series of tools for Scoliosis prevention and treatment. The set includes his book Your Plan for Natural Scoliosis Prevention and Treatment, a companion Scoliosis Exercises for Prevention and Correction DVD and the innovative new iPhone application ScolioTrack. Dr Kevin Lau D.C. is a graduate in Doctor of Chiropractic from RMIT University in Melbourne Australia and Masters in Holistic Nutrition from Clayton College of Natural Health in USA. In 2006 I was awarded the "Best Health-care Provider Awards" by the largest Newspaper publication in Singapore on October 18 2006 as well as being interviewed on Primetime Channel News Asia as well as other TV and Radio. For more information on Dr Kevin Lau, watch his interviews or get a free sneak peek of his book, go to: http://www.hiyh.info.
Read More


Systemic Inflammatory Response Syndrome in Cats

Declue AE, Delgado C, Chang C et al: Clinical and immunologic assessment of sepsis and the systemic inflammatory response syndrome in cats, J Am Vet Med Assoc 238:890, 2011.

Sepsis was previously defined as a blood-borne bacterial infection. It has recently been redefined as the systemic inflammatory response to any type of infectious organism, including bacteria, viruses, fungi, parasites, and protozoa. Sepsis is a very serious condition in cats that has a mortality rate ranging from 29% to 79%. The objective of this study was to compare clinical findings and inflammatory mediator production among cats with sepsis, cats with non-infectious systemic inflammatory response syndrome (SIRS), and healthy cats. The findings determined that the mortality rate was higher in cats with sepsis than for cats with noninfectious SIRS, but not significantly so. Cats with sepsis were more likely to have band cells and hypoalbuminemia than were cats with noninfectious SIRS. In addition, cats with sepsis had significantly greater plasma tumor necrosis factor activity and more likely to have detectible levels of interleukin-6 (IL-6) than were cats with noninfectious SIRS or healthy cats. The number of SIRS criteria fulfilled did not predict outcome. Plasma interleukin-1β activity and IL-6 as well as decreased chloride concentrations may be useful prognostic biomarkers for sepsis in cats. [VT]

Related articles:
Brady CA, Otto CM, Van Winkle TJ et al: Severe sepsis in cats: 29 cases (1986-1998), J Am Vet Med Assoc 217:531, 2000.

More on cat health: Winn Feline Foundation Library
Join us on Facebook
Follow us on Twitter
Declue AE, Delgado C, Chang C et al: Clinical and immunologic assessment of sepsis and the systemic inflammatory response syndrome in cats, J Am Vet Med Assoc 238:890, 2011.

Sepsis was previously defined as a blood-borne bacterial infection. It has recently been redefined as the systemic inflammatory response to any type of infectious organism, including bacteria, viruses, fungi, parasites, and protozoa. Sepsis is a very serious condition in cats that has a mortality rate ranging from 29% to 79%. The objective of this study was to compare clinical findings and inflammatory mediator production among cats with sepsis, cats with non-infectious systemic inflammatory response syndrome (SIRS), and healthy cats. The findings determined that the mortality rate was higher in cats with sepsis than for cats with noninfectious SIRS, but not significantly so. Cats with sepsis were more likely to have band cells and hypoalbuminemia than were cats with noninfectious SIRS. In addition, cats with sepsis had significantly greater plasma tumor necrosis factor activity and more likely to have detectible levels of interleukin-6 (IL-6) than were cats with noninfectious SIRS or healthy cats. The number of SIRS criteria fulfilled did not predict outcome. Plasma interleukin-1β activity and IL-6 as well as decreased chloride concentrations may be useful prognostic biomarkers for sepsis in cats. [VT]

Related articles:
Brady CA, Otto CM, Van Winkle TJ et al: Severe sepsis in cats: 29 cases (1986-1998), J Am Vet Med Assoc 217:531, 2000.

More on cat health: Winn Feline Foundation Library
Join us on Facebook
Follow us on Twitter
Read More


Friday, October 21, 2011

Improvement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study.

Pumpkin seed oil is rich in phytoestrogens and animal studies suggest that there is some benefit to supplementation in low estrogen conditions. This study is the first to evaluate the benefit of pumpkin seed oil in postmenopausal women.

METHODS: This pilot study was randomized, double-blinded and placebo-controlled. Study participants included 35 women who had undergone natural menopause or had iatrogenically entered the climacteric due to surgery for benign pathology. Wheat germ oil (placebo; n = 14) and pumpkin seed oil (n = 21) were administered to eligible participants over a 12-week period at a dose of 2 g per day. Serum lipids, fasting plasma glucose and blood pressure were measured and an 18-point questionnaire regarding menopausal symptoms was administered; the atherogenic index was also calculated. Differences between groups, as well as before and after the period of supplementation, were evaluated with Student's t-test, Wilcoxon matched-pair signed-ranked test and Mann-Whitney test, as appropriate (Stata version 10.1).

Women receiving pumpkin seed oil showed a significant increase in high density lipoprotein cholesterol concentrations (0.92 ± 0.23 mmol/l vs. 1.07 ± 0.27 mmol/l; p = 0.029) and decrease in diastolic blood pressure (81.1 ± 7.94 mmHg vs. 75.67 ± 11.93 mmHg; p < 0.046). There was also a significant improvement in the menopausal symptom scores (18.1 ± 9.0 vs. 13.2 ± 6.7; p < 0.030), with a decrease in severity of hot flushes, less headaches and less joint pains being the main contributors. Women in the group receiving wheat germ oil reported being more depressed and having more unloved feeling.

CONCLUSION: This pilot study showed pumpkin seed oil had some benefits for postmenopausal women and provided strong evidence to support further studies.
Pumpkin seed oil is rich in phytoestrogens and animal studies suggest that there is some benefit to supplementation in low estrogen conditions. This study is the first to evaluate the benefit of pumpkin seed oil in postmenopausal women.

METHODS: This pilot study was randomized, double-blinded and placebo-controlled. Study participants included 35 women who had undergone natural menopause or had iatrogenically entered the climacteric due to surgery for benign pathology. Wheat germ oil (placebo; n = 14) and pumpkin seed oil (n = 21) were administered to eligible participants over a 12-week period at a dose of 2 g per day. Serum lipids, fasting plasma glucose and blood pressure were measured and an 18-point questionnaire regarding menopausal symptoms was administered; the atherogenic index was also calculated. Differences between groups, as well as before and after the period of supplementation, were evaluated with Student's t-test, Wilcoxon matched-pair signed-ranked test and Mann-Whitney test, as appropriate (Stata version 10.1).

Women receiving pumpkin seed oil showed a significant increase in high density lipoprotein cholesterol concentrations (0.92 ± 0.23 mmol/l vs. 1.07 ± 0.27 mmol/l; p = 0.029) and decrease in diastolic blood pressure (81.1 ± 7.94 mmHg vs. 75.67 ± 11.93 mmHg; p < 0.046). There was also a significant improvement in the menopausal symptom scores (18.1 ± 9.0 vs. 13.2 ± 6.7; p < 0.030), with a decrease in severity of hot flushes, less headaches and less joint pains being the main contributors. Women in the group receiving wheat germ oil reported being more depressed and having more unloved feeling.

CONCLUSION: This pilot study showed pumpkin seed oil had some benefits for postmenopausal women and provided strong evidence to support further studies.
Read More


Vitamin D in diet and depression

Think of a study of more than 81,000 women. How much time do you think such a study would take; how much effort from the scientists? Then say it was prospective, that is, it looked into the future from the past. Dr. Elizabeth Bertone-Johnson, from the University of Massachusetts, senior author JoAnn Manson, from Harvard, and 12 colleagues from the Women’s Health Initiative did just that in a paper published in October of 2011. They looked at vitamin D intake from foods and supplements and current and later symptoms of depression.

Bertone-Johnson ER, Powers SI, Spangler L, Brunner RL, Michael YL, Larson JC, Millen AE, Bueche MN, Salmoirago-Blotcher E, Liu S, Wassertheil-Smoller S, Ockene JK, Ockene I, Manson JE. Vitamin D intake from foods and supplements and depressive symptoms in a diverse population of older women. Am J Clin Nutr. 2011 Oct;94(4):1104-12

The authors begin,

“Vitamin D may affect the function of dopamine and norepinephrine, which are monoamine neurotransmitters that are likely involved in depression. Furthermore, vitamin D may modulate the relation between depression and inflammation.”

They assessed 81,000 women at baseline (1993 -1998) and 3 years later for depression, using a simple depression rating scale, and for total vitamin D intake from foods and supplements. Their finding:

“In cross-sectional analysis that used baseline data, women with the highest intake of vitamin D and vitamin D from food sources had a significantly lower prevalence of depressive symptoms. . . In women without depressive symptoms at baseline, a higher vitamin D intake from food as associated with a lower risk of depression at year 3.”



However, they added,

“We did not find supplemental vitamin D intakes to be consistently related to measures of depressive symptoms.”
Explaining that in their group of women, for surprising and unknown reasons, vitamin D levels were higher in women who did not use vitamin D supplements. Remember in 1998, vitamin D supplements were either cod liver oil or multivitamins, both of which contained little vitamin D and toxic amounts of preformed retinol in the 1990s.

They went on to quote studies indicating that not 90%, but only 30% of vitamin D currently comes from sunlight. “Recent evidence suggested that only ~30% of circulating 25(OH)D is the product of sunlight exposure.” The studies indicating 90% comes from sunlight expose were from the early 1980s, when 90% did come from sunlight. This change from 90% to 30% reflects just how much we have become sunless creatures. Nature must have been totally surprised, when one day in the late 1980s, we suddenly decided that the Nature’s gift of sunlight was evil.

The authors conclude,

“Our results support an inverse association of vitamin D intake from foods and the occurrence of depressive symptoms in older women.”
Think of a study of more than 81,000 women. How much time do you think such a study would take; how much effort from the scientists? Then say it was prospective, that is, it looked into the future from the past. Dr. Elizabeth Bertone-Johnson, from the University of Massachusetts, senior author JoAnn Manson, from Harvard, and 12 colleagues from the Women’s Health Initiative did just that in a paper published in October of 2011. They looked at vitamin D intake from foods and supplements and current and later symptoms of depression.

Bertone-Johnson ER, Powers SI, Spangler L, Brunner RL, Michael YL, Larson JC, Millen AE, Bueche MN, Salmoirago-Blotcher E, Liu S, Wassertheil-Smoller S, Ockene JK, Ockene I, Manson JE. Vitamin D intake from foods and supplements and depressive symptoms in a diverse population of older women. Am J Clin Nutr. 2011 Oct;94(4):1104-12

The authors begin,

“Vitamin D may affect the function of dopamine and norepinephrine, which are monoamine neurotransmitters that are likely involved in depression. Furthermore, vitamin D may modulate the relation between depression and inflammation.”

They assessed 81,000 women at baseline (1993 -1998) and 3 years later for depression, using a simple depression rating scale, and for total vitamin D intake from foods and supplements. Their finding:

“In cross-sectional analysis that used baseline data, women with the highest intake of vitamin D and vitamin D from food sources had a significantly lower prevalence of depressive symptoms. . . In women without depressive symptoms at baseline, a higher vitamin D intake from food as associated with a lower risk of depression at year 3.”



However, they added,

“We did not find supplemental vitamin D intakes to be consistently related to measures of depressive symptoms.”
Explaining that in their group of women, for surprising and unknown reasons, vitamin D levels were higher in women who did not use vitamin D supplements. Remember in 1998, vitamin D supplements were either cod liver oil or multivitamins, both of which contained little vitamin D and toxic amounts of preformed retinol in the 1990s.

They went on to quote studies indicating that not 90%, but only 30% of vitamin D currently comes from sunlight. “Recent evidence suggested that only ~30% of circulating 25(OH)D is the product of sunlight exposure.” The studies indicating 90% comes from sunlight expose were from the early 1980s, when 90% did come from sunlight. This change from 90% to 30% reflects just how much we have become sunless creatures. Nature must have been totally surprised, when one day in the late 1980s, we suddenly decided that the Nature’s gift of sunlight was evil.

The authors conclude,

“Our results support an inverse association of vitamin D intake from foods and the occurrence of depressive symptoms in older women.”
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Tuesday, October 18, 2011

PCR Testing for Feline Respiratory Viruses

Ruch-Gallie RA, Veir JK, Hawley JR et al: Results of molecular diagnostic assays targeting feline herpesvirus-1 and feline calicivirus in adult cats administered modified live vaccines, J Feline Med Surg 13:541, 2011.

Diagnostic testing to identify the cause of a respiratory infection in a cat today often involves molecular testing of swabs collected from the nasal and pharyngeal areas. These assays detect the genetic material of the virus of interest. These molecular assays, known as real-time polymerase chain reaction (RT-PCR), are very sensitive, able to detect very small amounts virus. Vaccines given to cats, including cats entering shelters, are usually live virus vaccines. When respiratory disease occurs in these cats soon after vaccination, the concern is that the molecular assays may detect the vaccine virus, confusing the diagnosis. These researchers investigated the likelihood of detecting virus in the days immediately following vaccination. They tested multiple samples collected from six cats given an intranasal vaccine and six given a subcutaneous vaccine. Overall, the detection of virus within days after vaccination was uncommon. The risk was slightly higher with intranasal vaccines versus the subcutaneous vaccines. But the percentage of samples collected that gave positive results was quite small. Thus, the risk of false positive results from vaccination appears to be low. [MK]

Related articles:
Maggs D, Clarke H: Relative sensitivity of polymerase chain reaction assays used for detection of feline herpesvirus type 1 DNA in clinical samples and commercial vaccines, Am J Vet Res 66:1550, 2005.

More on cat health: Winn Feline Foundation Library
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Ruch-Gallie RA, Veir JK, Hawley JR et al: Results of molecular diagnostic assays targeting feline herpesvirus-1 and feline calicivirus in adult cats administered modified live vaccines, J Feline Med Surg 13:541, 2011.

Diagnostic testing to identify the cause of a respiratory infection in a cat today often involves molecular testing of swabs collected from the nasal and pharyngeal areas. These assays detect the genetic material of the virus of interest. These molecular assays, known as real-time polymerase chain reaction (RT-PCR), are very sensitive, able to detect very small amounts virus. Vaccines given to cats, including cats entering shelters, are usually live virus vaccines. When respiratory disease occurs in these cats soon after vaccination, the concern is that the molecular assays may detect the vaccine virus, confusing the diagnosis. These researchers investigated the likelihood of detecting virus in the days immediately following vaccination. They tested multiple samples collected from six cats given an intranasal vaccine and six given a subcutaneous vaccine. Overall, the detection of virus within days after vaccination was uncommon. The risk was slightly higher with intranasal vaccines versus the subcutaneous vaccines. But the percentage of samples collected that gave positive results was quite small. Thus, the risk of false positive results from vaccination appears to be low. [MK]

Related articles:
Maggs D, Clarke H: Relative sensitivity of polymerase chain reaction assays used for detection of feline herpesvirus type 1 DNA in clinical samples and commercial vaccines, Am J Vet Res 66:1550, 2005.

More on cat health: Winn Feline Foundation Library
Join us on Facebook
Follow us on Twitter
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Study finds good diet overcomes bad genes


Tuesday, October 18, 2011. In an article published online on October 11, 2011 in the journal PLoS Medicine, Dr Jamie Engert at McGill University in Montreal and his associates report that the risk conferred by a gene variant known to be a strong marker for cardiovascular disease is minimized by consuming a diet rich in fruit and vegetables. "We know that 9p21 genetic variants increase the risk of heart disease for those that carry it," explained Dr Engert, of the Research Institute of the McGill University Health Centre. "But it was a surprise to find that a healthy diet could significantly weaken its effect."

The researchers genotyped four variants in the 9p21 chromosome region of 8,114 participants in the INTERHEART study, a case-control study of men and women of varying ethnic backgrounds that compared those who had had an acute non-fatal heart attack to similar subjects without heart disease. Additionally, 9p21 variants were analyzed in 19,129 participants in the FINRISK study, of whom 1,014 had cardiovascular disease. Dietary questionnaires ascertained the frequency of intake of vegetables, fruits and other foods.


Subjects whose intake of vegetables and fruit was low had the greatest risk of cardiovascular disease in association with a 9p21 variant compared to those whose intake was high. Among INTERHEART participants who consumed a diet rich in fruit and raw vegetables, the risk of heart attack was similar between carriers and non-carriers of a specific single nucleotide polymorphism in the 9p21 region. In the FINRISK study, having a high risk genotype was associated with a greater risk of cardiovascular disease among those with low or average intake of fruit, vegetables and berries, yet among those whose intake of these foods was high, the variant appeared to have no effect.

"We observed that the effect of a high-risk genotype can be mitigated by consuming a diet high in fruits and vegetables," commented coauthor Sonia Anand, who is a professor of medicine and epidemiology at the Michael G. DeGroote School of Medicine at McMaster University. "Our results support the public health recommendation to consume more than five servings of fruits or vegetables as a way to promote good health."

"Our research suggests there may be an important interplay between genes and diet in cardiovascular disease," stated lead author Dr Ron Do, who is currently affiliated with Massachusetts General Hospital. "Future research is necessary to understand the mechanism of this interaction, which will shed light on the underlying metabolic processes that the 9p21 gene is involved in."



About Dr Kevin Lau
Dr Kevin Lau DC is the founder of Health In Your Hands, a series of tools for Scoliosis prevention and treatment. The set includes his book Your Plan for Natural Scoliosis Prevention and Treatment, a companion Scoliosis Exercises for Prevention and Correction DVD and the innovative new iPhone application ScolioTrack. Dr Kevin Lau D.C. is a graduate in Doctor of Chiropractic from RMIT University in Melbourne Australia and Masters in Holistic Nutrition from Clayton College of Natural Health in USA. In 2006 I was awarded the "Best Health-care Provider Awards" by the largest Newspaper publication in Singapore on October 18 2006 as well as being interviewed on Primetime Channel News Asia as well as other TV and Radio. For more information on Dr Kevin Lau, watch his interviews or get a free sneak peek of his book, go to: http://www.hiyh.info.

Tuesday, October 18, 2011. In an article published online on October 11, 2011 in the journal PLoS Medicine, Dr Jamie Engert at McGill University in Montreal and his associates report that the risk conferred by a gene variant known to be a strong marker for cardiovascular disease is minimized by consuming a diet rich in fruit and vegetables. "We know that 9p21 genetic variants increase the risk of heart disease for those that carry it," explained Dr Engert, of the Research Institute of the McGill University Health Centre. "But it was a surprise to find that a healthy diet could significantly weaken its effect."

The researchers genotyped four variants in the 9p21 chromosome region of 8,114 participants in the INTERHEART study, a case-control study of men and women of varying ethnic backgrounds that compared those who had had an acute non-fatal heart attack to similar subjects without heart disease. Additionally, 9p21 variants were analyzed in 19,129 participants in the FINRISK study, of whom 1,014 had cardiovascular disease. Dietary questionnaires ascertained the frequency of intake of vegetables, fruits and other foods.


Subjects whose intake of vegetables and fruit was low had the greatest risk of cardiovascular disease in association with a 9p21 variant compared to those whose intake was high. Among INTERHEART participants who consumed a diet rich in fruit and raw vegetables, the risk of heart attack was similar between carriers and non-carriers of a specific single nucleotide polymorphism in the 9p21 region. In the FINRISK study, having a high risk genotype was associated with a greater risk of cardiovascular disease among those with low or average intake of fruit, vegetables and berries, yet among those whose intake of these foods was high, the variant appeared to have no effect.

"We observed that the effect of a high-risk genotype can be mitigated by consuming a diet high in fruits and vegetables," commented coauthor Sonia Anand, who is a professor of medicine and epidemiology at the Michael G. DeGroote School of Medicine at McMaster University. "Our results support the public health recommendation to consume more than five servings of fruits or vegetables as a way to promote good health."

"Our research suggests there may be an important interplay between genes and diet in cardiovascular disease," stated lead author Dr Ron Do, who is currently affiliated with Massachusetts General Hospital. "Future research is necessary to understand the mechanism of this interaction, which will shed light on the underlying metabolic processes that the 9p21 gene is involved in."



About Dr Kevin Lau
Dr Kevin Lau DC is the founder of Health In Your Hands, a series of tools for Scoliosis prevention and treatment. The set includes his book Your Plan for Natural Scoliosis Prevention and Treatment, a companion Scoliosis Exercises for Prevention and Correction DVD and the innovative new iPhone application ScolioTrack. Dr Kevin Lau D.C. is a graduate in Doctor of Chiropractic from RMIT University in Melbourne Australia and Masters in Holistic Nutrition from Clayton College of Natural Health in USA. In 2006 I was awarded the "Best Health-care Provider Awards" by the largest Newspaper publication in Singapore on October 18 2006 as well as being interviewed on Primetime Channel News Asia as well as other TV and Radio. For more information on Dr Kevin Lau, watch his interviews or get a free sneak peek of his book, go to: http://www.hiyh.info.
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