Rickettsial Infections in Cats

Bayliss, D. B., A. K. Morris, et al. (2009). "Prevalence of Rickettsia species antibodies and Rickettsia species DNA in the blood of cats with and without fever." J Feline Med Surg 11(4): 266-70.

The purpose of the study was to determine if cats with a fever were more likely to have evidence of rickettsial infection than healthy, age-matched, control cats with no fever. Fever was determined to be a body temperature of over 102.5F (39.2C). The prevalence of Rickettsia species DNA in blood from clinically ill cats has not been determined. Rickettsia species antibodies have been detected in some cats but it is unknown whether infected cats develop clinical signs. Fever in humans has been attributed at times to “stealth” organisms that can evade the immune system, cause subtle clinical signs, and are not easily detectable by traditional diagnostic methods. Investigators questioned whether Rickettsia species might fill such a role in cats. The cat flea has been identified as a host and biological vector of R. felis and the question of whether the flea may be capable of transmitting the organism to cats is unanswered. The study results did not show an association between fever in cats and Rickettsia species DNA in blood or serologic evidence of exposure to R. felis. It would be optimal though to collect samples from clinically ill cats more than one time to further study this issue. [VT]
>> PubMed Abstract

Related articles:
Hawley, J. R., S. E. Shaw, et al. (2007). "Prevalence of Rickettsia felis DNA in the blood of cats and their fleas in the United States." J Feline Med Surg 9(3): 258-62.
>> PubMed Abstract

Kamrani, A., V. R. Parreira, et al. (2008). "The prevalence of Bartonella, hemoplasma, and Rickettsia felis infections in domestic cats and in cat fleas in Ontario." Can J Vet Res 72(5): 411-9.
>> Free full text article

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Bayliss, D. B., A. K. Morris, et al. (2009). "Prevalence of Rickettsia species antibodies and Rickettsia species DNA in the blood of cats with and without fever." J Feline Med Surg 11(4): 266-70.

The purpose of the study was to determine if cats with a fever were more likely to have evidence of rickettsial infection than healthy, age-matched, control cats with no fever. Fever was determined to be a body temperature of over 102.5F (39.2C). The prevalence of Rickettsia species DNA in blood from clinically ill cats has not been determined. Rickettsia species antibodies have been detected in some cats but it is unknown whether infected cats develop clinical signs. Fever in humans has been attributed at times to “stealth” organisms that can evade the immune system, cause subtle clinical signs, and are not easily detectable by traditional diagnostic methods. Investigators questioned whether Rickettsia species might fill such a role in cats. The cat flea has been identified as a host and biological vector of R. felis and the question of whether the flea may be capable of transmitting the organism to cats is unanswered. The study results did not show an association between fever in cats and Rickettsia species DNA in blood or serologic evidence of exposure to R. felis. It would be optimal though to collect samples from clinically ill cats more than one time to further study this issue. [VT]
>> PubMed Abstract

Related articles:
Hawley, J. R., S. E. Shaw, et al. (2007). "Prevalence of Rickettsia felis DNA in the blood of cats and their fleas in the United States." J Feline Med Surg 9(3): 258-62.
>> PubMed Abstract

Kamrani, A., V. R. Parreira, et al. (2008). "The prevalence of Bartonella, hemoplasma, and Rickettsia felis infections in domestic cats and in cat fleas in Ontario." Can J Vet Res 72(5): 411-9.
>> Free full text article

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Feline Leukemia Virus

Lutz, H., D. Addie, et al. (2009). "Feline leukaemia ABCD guidelines on prevention and management." J Feline Med Surg 11(7): 565-74.

Feline leukemia virus (FeLV) is a retrovirus found in cats everywhere in the world. While FeLV prevalence has decreased over the last few decades, primarily due to improvements in testing and vaccination, there are still millions of infected cats. Transmission of the virus occurs mainly via friendly contact, such as mutual grooming. Fortunately, the virus does not contaminate the environment as it is does not survive more than minutes outside the host. Young kittens are most at risk of infection. The most common clinical problems associated with FeLV infection are immunosuppression (with secondary infections), anemia, and lymphoma. Fortunately, effective vaccines exist against FeLV for cats at risk of infection. [SL]
>> PubMed Abstract
>> European Advisory Board on Cat Diseases

Related articles:
Levy, J., C. Crawford, et al. (2008). "2008 American Association of Feline Practitioners' feline retrovirus management guidelines." Journal of Feline Medicine & Surgery 10(3): 300-316.
>> Full text article

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Lutz, H., D. Addie, et al. (2009). "Feline leukaemia ABCD guidelines on prevention and management." J Feline Med Surg 11(7): 565-74.

Feline leukemia virus (FeLV) is a retrovirus found in cats everywhere in the world. While FeLV prevalence has decreased over the last few decades, primarily due to improvements in testing and vaccination, there are still millions of infected cats. Transmission of the virus occurs mainly via friendly contact, such as mutual grooming. Fortunately, the virus does not contaminate the environment as it is does not survive more than minutes outside the host. Young kittens are most at risk of infection. The most common clinical problems associated with FeLV infection are immunosuppression (with secondary infections), anemia, and lymphoma. Fortunately, effective vaccines exist against FeLV for cats at risk of infection. [SL]
>> PubMed Abstract
>> European Advisory Board on Cat Diseases

Related articles:
Levy, J., C. Crawford, et al. (2008). "2008 American Association of Feline Practitioners' feline retrovirus management guidelines." Journal of Feline Medicine & Surgery 10(3): 300-316.
>> Full text article

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Feline Calicivirus and Fleas

Mencke, N., M. Vobis, et al. (2009). "Transmission of feline calicivirus via the cat flea (Ctenocephalides felis)." Parasitol Res 105(1): 185-9.

Feline calicivirus is an important and contagious pathogen of cats. It is often associated with respiratory disease that is most commonly mild and self-limiting. However, it may cause severe pneumonia, or rarely, a systemic lethal disease. Transmission occurs most commonly through direct and indirect contact between cats. This investigation examined the potential for fleas to spread the virus. Fleas were fed blood containing the virus, and their feces were collected. Infectious virus was found in the flea feces for more than a week after exposure, and the virus could be transmitted to susceptible kittens via the fleas. Thus fleas could be a potential source for spread of this virus. However, the level of virus artificially fed to the fleas in this experiment was very high. In addition, while inoculation of infected fleas via the nose and mouth in the kittens was effective in transmission, infestation of the kittens alone with the fleas was not efficient for virus transmission. The researchers conclude that fleas could potentially be a source for transmission of feline calicivirus and note that it emphasizes the importance of good flea control. However, spread by respiratory droplets and direct contact remains the most important modes of spread. Transmission via fleas would most likely be significant in situations of crowding and significant flea infestation. [MK]
>> PubMed Abstract

Related articles:
Radford, A. D., D. Addie, et al. (2009). "Feline calicivirus infection ABCD guidelines on prevention and management." J Feline Med Surg 11(7): 556-64.
>> PubMed Abstract

Hurley, K., P. Pesavento, et al. (2004). "An outbreak of virulent systemic feline calicivirus disease." J Amer Vet Med Assoc 224(2): 241-249.
>> PubMed Abstract

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Mencke, N., M. Vobis, et al. (2009). "Transmission of feline calicivirus via the cat flea (Ctenocephalides felis)." Parasitol Res 105(1): 185-9.

Feline calicivirus is an important and contagious pathogen of cats. It is often associated with respiratory disease that is most commonly mild and self-limiting. However, it may cause severe pneumonia, or rarely, a systemic lethal disease. Transmission occurs most commonly through direct and indirect contact between cats. This investigation examined the potential for fleas to spread the virus. Fleas were fed blood containing the virus, and their feces were collected. Infectious virus was found in the flea feces for more than a week after exposure, and the virus could be transmitted to susceptible kittens via the fleas. Thus fleas could be a potential source for spread of this virus. However, the level of virus artificially fed to the fleas in this experiment was very high. In addition, while inoculation of infected fleas via the nose and mouth in the kittens was effective in transmission, infestation of the kittens alone with the fleas was not efficient for virus transmission. The researchers conclude that fleas could potentially be a source for transmission of feline calicivirus and note that it emphasizes the importance of good flea control. However, spread by respiratory droplets and direct contact remains the most important modes of spread. Transmission via fleas would most likely be significant in situations of crowding and significant flea infestation. [MK]
>> PubMed Abstract

Related articles:
Radford, A. D., D. Addie, et al. (2009). "Feline calicivirus infection ABCD guidelines on prevention and management." J Feline Med Surg 11(7): 556-64.
>> PubMed Abstract

Hurley, K., P. Pesavento, et al. (2004). "An outbreak of virulent systemic feline calicivirus disease." J Amer Vet Med Assoc 224(2): 241-249.
>> PubMed Abstract

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Can Cats Count?

Pisa, P. E. and C. Agrillo (2009). "Quantity discrimination in felines: a preliminary investigation of the domestic cat (Felis silvestris catus) " J Ethology 27(2): 289-293.

The ability to count, while complicated, is not limited to humans. The simplest form of this is being able to discriminate between two different quantities of objects, and this ability may enhance survival in different ways. Little work has been done on this area in cats. In this study, four pet cats were trained to discriminate between groups of two and three dots for a food reward. The investigators demonstrated that cats can learn how to distinguish between two groups of objects that differed only in number. Interestingly, they concluded that cats do not spontaneously use numerical information, but rather make use of visual cues to solve the task. [VT]
>> Journal Abstract

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Pisa, P. E. and C. Agrillo (2009). "Quantity discrimination in felines: a preliminary investigation of the domestic cat (Felis silvestris catus) " J Ethology 27(2): 289-293.

The ability to count, while complicated, is not limited to humans. The simplest form of this is being able to discriminate between two different quantities of objects, and this ability may enhance survival in different ways. Little work has been done on this area in cats. In this study, four pet cats were trained to discriminate between groups of two and three dots for a food reward. The investigators demonstrated that cats can learn how to distinguish between two groups of objects that differed only in number. Interestingly, they concluded that cats do not spontaneously use numerical information, but rather make use of visual cues to solve the task. [VT]
>> Journal Abstract

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Renal Dysplasia in a Norwegian Forest Cat

Aresu, L., R. Zanatta, et al. (2009). "Bilateral juvenile renal dysplasia in a Norwegian Forest Cat." J Feline Med Surg 11(4): 326-9.

Renal dysplasia is a kidney malformation made up of disorganized development of renal parenchyma due to abnormal differentiation. This condition leads to chronic renal failure in young animals. In addition to cats, renal dysplastic lesions have been found in dogs, cattle, horses, sheep, and humans. Renal dysplasia can be diagnosed only by histological examination of biopsy samples. The dysplasia can be unilateral or bilateral. In this case of a 5-month old Norwegian Forest cat, where the disease was bilateral, renal failure was the ultimate result. Kittens can often be clinically normal for extended periods of time; however, most of clinical signs are seen before 2 years of age. Feline renal dysplasia has been reported in fetal infections with panleukopenia virus. There are no reports of familial origins in feline renal dysplastic lesions. [VT]
>> PubMed Abstract

Related articles:
Greco, D. (2001). "Congenital and inherited renal disease of small animals." Vet Clin North Amer: Sm Anim Pract 31(2): 393-399.
>> PubMed Abstract

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Aresu, L., R. Zanatta, et al. (2009). "Bilateral juvenile renal dysplasia in a Norwegian Forest Cat." J Feline Med Surg 11(4): 326-9.

Renal dysplasia is a kidney malformation made up of disorganized development of renal parenchyma due to abnormal differentiation. This condition leads to chronic renal failure in young animals. In addition to cats, renal dysplastic lesions have been found in dogs, cattle, horses, sheep, and humans. Renal dysplasia can be diagnosed only by histological examination of biopsy samples. The dysplasia can be unilateral or bilateral. In this case of a 5-month old Norwegian Forest cat, where the disease was bilateral, renal failure was the ultimate result. Kittens can often be clinically normal for extended periods of time; however, most of clinical signs are seen before 2 years of age. Feline renal dysplasia has been reported in fetal infections with panleukopenia virus. There are no reports of familial origins in feline renal dysplastic lesions. [VT]
>> PubMed Abstract

Related articles:
Greco, D. (2001). "Congenital and inherited renal disease of small animals." Vet Clin North Amer: Sm Anim Pract 31(2): 393-399.
>> PubMed Abstract

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Oxidative Stress in Feline Diabetes

Webb, C. B. and L. Falkowski (2009). "Oxidative stress and innate immunity in feline patients with diabetes mellitus: the role of nutrition." J Feline Med Surg 11(4): 271-6.

The study was performed to test the hypothesis that oxidative stress is increased and neutrophil function is decreased in cats with diabetes mellitus (DM). Oxidative stress is considered a key component in the pathophysiology of type 2 diabetes mellitus in people. It is estimated that 85% of cats with DM are type 2 diabetics. The study included 20 control and 15 diabetic cats with measurements for oxidative stress and neutrophil function. The cats were fed a diet designed for feline diabetics (Purina DM Dietetic Management Feline Formula) for 8 weeks, and then assays were repeated. Plasma superoxide dismutase (SOD) was significantly less in cats with DM than the control cats, consistent with a greater degree of oxidative stress in the DM group. Glutathione peroxidase, an antioxidant enzyme, was increased significantly in both groups following 8 weeks of consuming a diabetes-specific diet. Other parameters of oxidative stress studied, plus neutrophil function, were similar between groups and did not change following dietary intervention. The DM cats were significantly older and heavier than the control cats and these factors could have affected differences between the two groups. The findings support continued study of antioxidant supplementation and dietary intervention in diabetic cats. [VT]
>> PubMed Abstract

Related articles:
Webb, C. B., K. W. McCord, et al. (2009). "Assessment of oxidative stress in leukocytes and granulocyte function following oral administration of a silibinin-phosphatidylcholine complex in cats." American Journal of Veterinary Research 70(1): 57-62.
>> PubMed Abstract

Webb, C. B., T. L. Lehman, et al. (2008). "Effects of an oral superoxide dismutase enzyme supplementation on indices of oxidative stress, proviral load, and CD4:CD8 ratios in asymptomatic FIV-infected cats." Journal of Feline Medicine & Surgery 10(5): 423-430.
>> PubMed Abstract

More on cat health: Winn Feline Foundation Library
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Webb, C. B. and L. Falkowski (2009). "Oxidative stress and innate immunity in feline patients with diabetes mellitus: the role of nutrition." J Feline Med Surg 11(4): 271-6.

The study was performed to test the hypothesis that oxidative stress is increased and neutrophil function is decreased in cats with diabetes mellitus (DM). Oxidative stress is considered a key component in the pathophysiology of type 2 diabetes mellitus in people. It is estimated that 85% of cats with DM are type 2 diabetics. The study included 20 control and 15 diabetic cats with measurements for oxidative stress and neutrophil function. The cats were fed a diet designed for feline diabetics (Purina DM Dietetic Management Feline Formula) for 8 weeks, and then assays were repeated. Plasma superoxide dismutase (SOD) was significantly less in cats with DM than the control cats, consistent with a greater degree of oxidative stress in the DM group. Glutathione peroxidase, an antioxidant enzyme, was increased significantly in both groups following 8 weeks of consuming a diabetes-specific diet. Other parameters of oxidative stress studied, plus neutrophil function, were similar between groups and did not change following dietary intervention. The DM cats were significantly older and heavier than the control cats and these factors could have affected differences between the two groups. The findings support continued study of antioxidant supplementation and dietary intervention in diabetic cats. [VT]
>> PubMed Abstract

Related articles:
Webb, C. B., K. W. McCord, et al. (2009). "Assessment of oxidative stress in leukocytes and granulocyte function following oral administration of a silibinin-phosphatidylcholine complex in cats." American Journal of Veterinary Research 70(1): 57-62.
>> PubMed Abstract

Webb, C. B., T. L. Lehman, et al. (2008). "Effects of an oral superoxide dismutase enzyme supplementation on indices of oxidative stress, proviral load, and CD4:CD8 ratios in asymptomatic FIV-infected cats." Journal of Feline Medicine & Surgery 10(5): 423-430.
>> PubMed Abstract

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Cats and Zoonotic Parasites

Overgaauw, P. A., L. van Zutphen, et al. (2009). "Zoonotic parasites in fecal samples and fur from dogs and cats in The Netherlands." Vet Parasitol 163(1-2): 115-122.

All pet owners need to be aware of the risks of zoonotic pathogens - diseases which can be shared by animals and people. The purpose of this study from the Netherlands was to determine if healthy cats and dogs harbor zoonotic parasite infections, and to evaluate interactions between pets and owners. Both fecal and hair samples were collected from healthy cats and dogs in Dutch veterinary clinics, representing 159 households. Information and samples were collected on 152 dogs and 60 cats. Toxocara (roundworm) eggs were found in 4.6% of the cat fecal samples and in 3.4% of the cat fur samples. However, none of the eggs found in fur were viable. Giardia was isolated from 13.6% of the cat fecal samples and Cryptosporidium was isolated from 4.6% of the cat samples. In evaluating interactions between owners and pets, 50% of owners said they allowed the pet to lick their face, 60% of pets visited the bedroom, 60% of cats are allowed to sleep on the bed, and 30% of cats sleep with the owner in bed. Other interesting findings were that 45% of cats were allowed to jump into the kitchen sink, and 8% of cat owners always washed their hands after contact with their pet. The researchers conclude that close physical contact between owners and cats is common, and must be recognized as a risk factor for transmission of zoonotic pathogens. Owners should be informed about hygiene and risks of disease transmission. [SL]
>> PubMed Abstract

Related articles:
Palmer, C. S., I. D. Robertson, et al. (2009). "Intestinal parasites of dogs and cats in Australia: The veterinarian's perspective and pet owner awareness." Vet J.
>> PubMed Abstract

Stull, J. W., A. P. Carr, et al. (2007). "Small animal deworming protocols, client education, and veterinarian perception of zoonotic parasites in western Canada." Can Vet J 48(3): 269-76.
>> Free full text article

More on cat health: Winn Feline Foundation Library
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Overgaauw, P. A., L. van Zutphen, et al. (2009). "Zoonotic parasites in fecal samples and fur from dogs and cats in The Netherlands." Vet Parasitol 163(1-2): 115-122.

All pet owners need to be aware of the risks of zoonotic pathogens - diseases which can be shared by animals and people. The purpose of this study from the Netherlands was to determine if healthy cats and dogs harbor zoonotic parasite infections, and to evaluate interactions between pets and owners. Both fecal and hair samples were collected from healthy cats and dogs in Dutch veterinary clinics, representing 159 households. Information and samples were collected on 152 dogs and 60 cats. Toxocara (roundworm) eggs were found in 4.6% of the cat fecal samples and in 3.4% of the cat fur samples. However, none of the eggs found in fur were viable. Giardia was isolated from 13.6% of the cat fecal samples and Cryptosporidium was isolated from 4.6% of the cat samples. In evaluating interactions between owners and pets, 50% of owners said they allowed the pet to lick their face, 60% of pets visited the bedroom, 60% of cats are allowed to sleep on the bed, and 30% of cats sleep with the owner in bed. Other interesting findings were that 45% of cats were allowed to jump into the kitchen sink, and 8% of cat owners always washed their hands after contact with their pet. The researchers conclude that close physical contact between owners and cats is common, and must be recognized as a risk factor for transmission of zoonotic pathogens. Owners should be informed about hygiene and risks of disease transmission. [SL]
>> PubMed Abstract

Related articles:
Palmer, C. S., I. D. Robertson, et al. (2009). "Intestinal parasites of dogs and cats in Australia: The veterinarian's perspective and pet owner awareness." Vet J.
>> PubMed Abstract

Stull, J. W., A. P. Carr, et al. (2007). "Small animal deworming protocols, client education, and veterinarian perception of zoonotic parasites in western Canada." Can Vet J 48(3): 269-76.
>> Free full text article

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