Jeusette I., Salas A., et al. Increased urinary F2-isoprostane concentration as an indicator of oxidative stress in overweight cats. Intern J Appl Res Vet Med, 2009. 7(1-2):36-42.
Obesity is common in cats and can contribute to many health problems. These investigators examined the effects of body weight on the health status of cats, measuring several clinical parameters. Studies in humans and rats have shown that obesity is associated with oxidative stress and inflammation. Twenty overweight cats and seven lean cats were included in the study and all were healthy. Parameters measured were blood cholesterol, triacylglycerol (lipid), and inflammatory mediators (acute phase proteins). In addition, urinary isoprostane, another indicator of inflammation was assessed. While blood cholesterol and lipid levels did not significantly differ among the cats, urine F2-isoprostane levels were significantly higher in overweight cats. This component is an indicator of oxidative injury, and may play a role in disease development in overweight cats. The authors note that their study size was small, and did not include a control group. However, this preliminary work indicates that oxidative stress may have an impact on the health of overweight cats. [MK]
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